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Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis.
Neurosci Lett. 2014 Jun 06; 570:108-13.NL

Abstract

To estimate the associations between vitamin D status and multiple sclerosis (MS). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'multiple sclerosis'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and MS. Eleven studies met the inclusion criteria. 1007 patients and 829 controls were included. Results of our meta-analysis show that MS patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls (weighted mean difference[MD], -14.52, 95% confidence interval [CI], -23.83 to -5.22). There were statistically significant heterogeneity (P<0.00001; I(2)=92%). The significant heterogeneity may be due to the differences in ethnicity, country, season of blood sampling and age of the participants studied. To sum up, low vitamin D levels are associated with an increased risk of MS.

Authors+Show Affiliations

Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.Department of Rehabilitation, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China. Electronic address: bisheng13224510036@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24769422

Citation

Duan, Shurong, et al. "Vitamin D Status and the Risk of Multiple Sclerosis: a Systematic Review and Meta-analysis." Neuroscience Letters, vol. 570, 2014, pp. 108-13.
Duan S, Lv Z, Fan X, et al. Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis. Neurosci Lett. 2014;570:108-13.
Duan, S., Lv, Z., Fan, X., Wang, L., Han, F., Wang, H., & Bi, S. (2014). Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis. Neuroscience Letters, 570, 108-13. https://doi.org/10.1016/j.neulet.2014.04.021
Duan S, et al. Vitamin D Status and the Risk of Multiple Sclerosis: a Systematic Review and Meta-analysis. Neurosci Lett. 2014 Jun 6;570:108-13. PubMed PMID: 24769422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis. AU - Duan,Shurong, AU - Lv,Zheng, AU - Fan,Xiaoxue, AU - Wang,Le, AU - Han,Fei, AU - Wang,Hong, AU - Bi,Sheng, Y1 - 2014/04/24/ PY - 2014/03/14/received PY - 2014/04/10/revised PY - 2014/04/16/accepted PY - 2014/4/29/entrez PY - 2014/4/29/pubmed PY - 2014/12/15/medline KW - 25-Hydroxy vitamin D KW - Deficiency KW - Insufficiency KW - Multiple sclerosis SP - 108 EP - 13 JF - Neuroscience letters JO - Neurosci Lett VL - 570 N2 - To estimate the associations between vitamin D status and multiple sclerosis (MS). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'multiple sclerosis'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and MS. Eleven studies met the inclusion criteria. 1007 patients and 829 controls were included. Results of our meta-analysis show that MS patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls (weighted mean difference[MD], -14.52, 95% confidence interval [CI], -23.83 to -5.22). There were statistically significant heterogeneity (P<0.00001; I(2)=92%). The significant heterogeneity may be due to the differences in ethnicity, country, season of blood sampling and age of the participants studied. To sum up, low vitamin D levels are associated with an increased risk of MS. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24769422/Vitamin_D_status_and_the_risk_of_multiple_sclerosis:_a_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(14)00324-3 DB - PRIME DP - Unbound Medicine ER -