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[Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection].
Vopr Virusol. 2013 Nov-Dec; 58(6):36-9.VV

Abstract

Cold-adapted influenza virus A/HK/1/68/162/35(H3N2) was developed as unified donor of attenuation and high reproductive capacity forvaccine strains. The reassortant of this donor with surface antigens of highly pathogenic strain Alchicken/Astana/6/05 (H5N1) was tested in guinea pigs as a live or inactivated preparation. Immunization with both formulations induced equal levels of serum virus specific antibodies, while the level of mucosal antibodies was significantly higher in animals immunized with live virus. The challenge with the homologous virus demonstrated complete virus clearance only in this group, thereby indicating a direct correlation of the protection level with the level of mucosal antibodies.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

24772645

Citation

Sergeeva, M V., et al. "[Immunization With Live Attenuated A/H5N1 Vaccine Protects Guinea Pigs From Reinfection]." Voprosy Virusologii, vol. 58, no. 6, 2013, pp. 36-9.
Sergeeva MV, Kuznetsov VV, Kas'ianenko MA, et al. [Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection]. Vopr Virusol. 2013;58(6):36-9.
Sergeeva, M. V., Kuznetsov, V. V., Kas'ianenko, M. A., Shaldzhian, A. A., Repko, I. A., Potapchuk, M. V., Romanova, I. u. R., & Tsybalova, L. M. (2013). [Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection]. Voprosy Virusologii, 58(6), 36-9.
Sergeeva MV, et al. [Immunization With Live Attenuated A/H5N1 Vaccine Protects Guinea Pigs From Reinfection]. Vopr Virusol. 2013 Nov-Dec;58(6):36-9. PubMed PMID: 24772645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection]. AU - Sergeeva,M V, AU - Kuznetsov,V V, AU - Kas'ianenko,M A, AU - Shaldzhian,A A, AU - Repko,I A, AU - Potapchuk,M V, AU - Romanova,Iu R, AU - Tsybalova,L M, PY - 2014/4/30/entrez PY - 2014/4/30/pubmed PY - 2014/5/14/medline SP - 36 EP - 9 JF - Voprosy virusologii JO - Vopr Virusol VL - 58 IS - 6 N2 - Cold-adapted influenza virus A/HK/1/68/162/35(H3N2) was developed as unified donor of attenuation and high reproductive capacity forvaccine strains. The reassortant of this donor with surface antigens of highly pathogenic strain Alchicken/Astana/6/05 (H5N1) was tested in guinea pigs as a live or inactivated preparation. Immunization with both formulations induced equal levels of serum virus specific antibodies, while the level of mucosal antibodies was significantly higher in animals immunized with live virus. The challenge with the homologous virus demonstrated complete virus clearance only in this group, thereby indicating a direct correlation of the protection level with the level of mucosal antibodies. SN - 0507-4088 UR - https://www.unboundmedicine.com/medline/citation/24772645/[Immunization_with_live_attenuated_A/H5N1_vaccine_protects_guinea_pigs_from_reinfection]_ L2 - https://medlineplus.gov/birdflu.html DB - PRIME DP - Unbound Medicine ER -