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Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis: have you checked the ovaries?
Acta Obstet Gynecol Scand. 2014 Jul; 93(7):712-5.AO

Abstract

Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune disorder that can occur as a paraneoplastic phenomenon related to ovarian teratomas. It is a serious but reversible condition with improved outcomes following prompt tumor removal. We report two cases from our recent experience. In the first case a small poorly described lesion, confirmed as a teratoma only at histology, was managed by laparoscopic oopohorectomy. In the second case a large teratoma was managed by laparoscopic cystectomy. Postoperatively both women made a good recovery. Gynecologists may be called upon to perform ovarian surgery outside of normal surgical indications, in young women who will often lack capacity to consent. Fertility-sparing ovarian cystectomy is possible in some cases, but will be challenging for small deeply buried tumors. Blind bilateral oophorectomy has been performed successfully in extreme cases. Information of the benefit of ovarian surgery will be essential to the surgeon during preoperative counseling.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, The Royal London Hospital, Bart's Health NHS Trust, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24773063

Citation

Cleverly, Kirsty, et al. "Paraneoplastic anti-N-methyl-D-aspartate Receptor Encephalitis: Have You Checked the Ovaries?" Acta Obstetricia Et Gynecologica Scandinavica, vol. 93, no. 7, 2014, pp. 712-5.
Cleverly K, Gambadauro P, Navaratnarajah R. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis: have you checked the ovaries? Acta Obstet Gynecol Scand. 2014;93(7):712-5.
Cleverly, K., Gambadauro, P., & Navaratnarajah, R. (2014). Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis: have you checked the ovaries? Acta Obstetricia Et Gynecologica Scandinavica, 93(7), 712-5. https://doi.org/10.1111/aogs.12386
Cleverly K, Gambadauro P, Navaratnarajah R. Paraneoplastic anti-N-methyl-D-aspartate Receptor Encephalitis: Have You Checked the Ovaries. Acta Obstet Gynecol Scand. 2014;93(7):712-5. PubMed PMID: 24773063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis: have you checked the ovaries? AU - Cleverly,Kirsty, AU - Gambadauro,Pietro, AU - Navaratnarajah,Ramesan, Y1 - 2014/04/29/ PY - 2014/02/20/received PY - 2014/03/25/accepted PY - 2014/4/30/entrez PY - 2014/4/30/pubmed PY - 2014/8/6/medline KW - Encephalitis KW - anti-N-methyl-d-aspartate receptor encephalitis KW - autoantibodies KW - laparoscopy KW - ovarian neoplasms KW - paraneoplastic syndromes KW - receptors N-methyl-d-aspartate KW - teratoma SP - 712 EP - 5 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 93 IS - 7 N2 - Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune disorder that can occur as a paraneoplastic phenomenon related to ovarian teratomas. It is a serious but reversible condition with improved outcomes following prompt tumor removal. We report two cases from our recent experience. In the first case a small poorly described lesion, confirmed as a teratoma only at histology, was managed by laparoscopic oopohorectomy. In the second case a large teratoma was managed by laparoscopic cystectomy. Postoperatively both women made a good recovery. Gynecologists may be called upon to perform ovarian surgery outside of normal surgical indications, in young women who will often lack capacity to consent. Fertility-sparing ovarian cystectomy is possible in some cases, but will be challenging for small deeply buried tumors. Blind bilateral oophorectomy has been performed successfully in extreme cases. Information of the benefit of ovarian surgery will be essential to the surgeon during preoperative counseling. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/24773063/Paraneoplastic_anti_N_methyl_D_aspartate_receptor_encephalitis:_have_you_checked_the_ovaries L2 - https://doi.org/10.1111/aogs.12386 DB - PRIME DP - Unbound Medicine ER -