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Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case-control, cohort and intervention studies.
Br J Nutr 2014; 112(2):248-59BJ

Abstract

Increasing evidence suggests that the Mediterranean diet can reduce the risk of CVD. Olive oil is the hallmark of this dietary pattern. We conducted a meta-analysis of case-control, prospective cohort studies and a randomised controlled trial investigating the specific association between olive oil consumption and the risk of CHD (101,460 participants) or stroke (38,673 participants). The results of all observational studies were adjusted for total energy intake. The random-effects model assessing CHD as an outcome showed a relative risk (RR) of 0.73 (95% CI 0.44, 1.21) in case-control studies and 0.96 (95% CI 0.78, 1.18) in cohort studies for a 25 g increase in olive oil consumption. In cohort studies, the random-effects model assessing stroke showed a RR of 0.74 (95% CI 0.60, 0.92). The random-effects model combining all cardiovascular events (CHD and stroke) showed a RR of 0.82 (95% CI 0.70, 0.96). Evidence of heterogeneity was apparent for CHD, but not for stroke. Both the Egger test (P= 0.06) and the funnel plot suggested small-study effects. Available studies support an inverse association of olive oil consumption with stroke (and with stroke and CHD combined), but no significant association with CHD. This finding is in agreement with the recent successful results of the PREDIMED randomised controlled trial.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health,University of Navarra,Pamplona,Spain.Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo,Via F. Scaduto 6/c,90144Palermo,Italy.Division of Medicine and Health Sciences, University of Jaen,Jaen,Spain.

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24775425

Citation

Martínez-González, Miguel A., et al. "Olive Oil Consumption and Risk of CHD And/or Stroke: a Meta-analysis of Case-control, Cohort and Intervention Studies." The British Journal of Nutrition, vol. 112, no. 2, 2014, pp. 248-59.
Martínez-González MA, Dominguez LJ, Delgado-Rodríguez M. Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case-control, cohort and intervention studies. Br J Nutr. 2014;112(2):248-59.
Martínez-González, M. A., Dominguez, L. J., & Delgado-Rodríguez, M. (2014). Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case-control, cohort and intervention studies. The British Journal of Nutrition, 112(2), pp. 248-59. doi:10.1017/S0007114514000713.
Martínez-González MA, Dominguez LJ, Delgado-Rodríguez M. Olive Oil Consumption and Risk of CHD And/or Stroke: a Meta-analysis of Case-control, Cohort and Intervention Studies. Br J Nutr. 2014 Jul 28;112(2):248-59. PubMed PMID: 24775425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case-control, cohort and intervention studies. AU - Martínez-González,Miguel A, AU - Dominguez,Ligia J, AU - Delgado-Rodríguez,Miguel, Y1 - 2014/04/28/ PY - 2014/4/30/entrez PY - 2014/4/30/pubmed PY - 2014/9/3/medline SP - 248 EP - 59 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 112 IS - 2 N2 - Increasing evidence suggests that the Mediterranean diet can reduce the risk of CVD. Olive oil is the hallmark of this dietary pattern. We conducted a meta-analysis of case-control, prospective cohort studies and a randomised controlled trial investigating the specific association between olive oil consumption and the risk of CHD (101,460 participants) or stroke (38,673 participants). The results of all observational studies were adjusted for total energy intake. The random-effects model assessing CHD as an outcome showed a relative risk (RR) of 0.73 (95% CI 0.44, 1.21) in case-control studies and 0.96 (95% CI 0.78, 1.18) in cohort studies for a 25 g increase in olive oil consumption. In cohort studies, the random-effects model assessing stroke showed a RR of 0.74 (95% CI 0.60, 0.92). The random-effects model combining all cardiovascular events (CHD and stroke) showed a RR of 0.82 (95% CI 0.70, 0.96). Evidence of heterogeneity was apparent for CHD, but not for stroke. Both the Egger test (P= 0.06) and the funnel plot suggested small-study effects. Available studies support an inverse association of olive oil consumption with stroke (and with stroke and CHD combined), but no significant association with CHD. This finding is in agreement with the recent successful results of the PREDIMED randomised controlled trial. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/24775425/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114514000713/type/journal_article DB - PRIME DP - Unbound Medicine ER -