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The comparison of thyroxine versus thyroxine plus oral iodine in the treatment of congenital hypothyroidism due to iodine deficiency.
Horm Res Paediatr 2014; 81(6):409-15HR

Abstract

AIM

Iodine deficiency is one of the most important causes of congenital hypothyroidism. In addition to thyroid hormone replacement, iodine supplementation is also given to newborns with congenital hypothyroidism due to iodine deficiency. We aimed to determine whether it is beneficial to administer iodine supplementation in addition to the L-thyroxine (L-T4) treatment of newborns with congenital hypothyroidism due to iodine deficiency.

MATERIALS AND METHODS

Of 51 newborns, 26 who were diagnosed with congenital hypothyroidism due to iodine deficiency were treated with L-T4. The remaining 25 cases were given L-T4 plus 100 μg/day of oral iodine. Free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), thyroglobulin (TG), thyroid volume, urine iodine and breast milk iodine levels were measured in the first and third months of treatment, and the data were compared between the two groups.

RESULTS

First- and third-month values of fT3, fT4, TSH, TG and thyroid volume for both groups were statistically similar. There was no significant difference between the two groups in respect to falling levels of fT3 and TSH, the rate of increase of fT4 levels or the shrinkage rate of thyroid volume.

CONCLUSION

In this study, the addition of oral iodine to L-T4 treatment provided no benefit compared to treatment with L-T4 alone.

Authors+Show Affiliations

Department of Neonatology and Pediatric Endocrinology, Erciyes University Medical Faculty, Kayseri, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24776962

Citation

Kurtoğlu, Selim, et al. "The Comparison of Thyroxine Versus Thyroxine Plus Oral Iodine in the Treatment of Congenital Hypothyroidism Due to Iodine Deficiency." Hormone Research in Paediatrics, vol. 81, no. 6, 2014, pp. 409-15.
Kurtoğlu S, Köroğlu Ş, Baştuğ O, et al. The comparison of thyroxine versus thyroxine plus oral iodine in the treatment of congenital hypothyroidism due to iodine deficiency. Horm Res Paediatr. 2014;81(6):409-15.
Kurtoğlu, S., Köroğlu, Ş., Baştuğ, O., Daar, G., Yıkılmaz, A., & Elmalı, F. (2014). The comparison of thyroxine versus thyroxine plus oral iodine in the treatment of congenital hypothyroidism due to iodine deficiency. Hormone Research in Paediatrics, 81(6), pp. 409-15. doi:10.1159/000358878.
Kurtoğlu S, et al. The Comparison of Thyroxine Versus Thyroxine Plus Oral Iodine in the Treatment of Congenital Hypothyroidism Due to Iodine Deficiency. Horm Res Paediatr. 2014;81(6):409-15. PubMed PMID: 24776962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The comparison of thyroxine versus thyroxine plus oral iodine in the treatment of congenital hypothyroidism due to iodine deficiency. AU - Kurtoğlu,Selim, AU - Köroğlu,Şenol, AU - Baştuğ,Osman, AU - Daar,Ghaniya, AU - Yıkılmaz,Ali, AU - Elmalı,Ferhan, Y1 - 2014/04/24/ PY - 2013/08/20/received PY - 2014/01/21/accepted PY - 2014/4/30/entrez PY - 2014/4/30/pubmed PY - 2015/3/3/medline SP - 409 EP - 15 JF - Hormone research in paediatrics JO - Horm Res Paediatr VL - 81 IS - 6 N2 - AIM: Iodine deficiency is one of the most important causes of congenital hypothyroidism. In addition to thyroid hormone replacement, iodine supplementation is also given to newborns with congenital hypothyroidism due to iodine deficiency. We aimed to determine whether it is beneficial to administer iodine supplementation in addition to the L-thyroxine (L-T4) treatment of newborns with congenital hypothyroidism due to iodine deficiency. MATERIALS AND METHODS: Of 51 newborns, 26 who were diagnosed with congenital hypothyroidism due to iodine deficiency were treated with L-T4. The remaining 25 cases were given L-T4 plus 100 μg/day of oral iodine. Free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), thyroglobulin (TG), thyroid volume, urine iodine and breast milk iodine levels were measured in the first and third months of treatment, and the data were compared between the two groups. RESULTS: First- and third-month values of fT3, fT4, TSH, TG and thyroid volume for both groups were statistically similar. There was no significant difference between the two groups in respect to falling levels of fT3 and TSH, the rate of increase of fT4 levels or the shrinkage rate of thyroid volume. CONCLUSION: In this study, the addition of oral iodine to L-T4 treatment provided no benefit compared to treatment with L-T4 alone. SN - 1663-2826 UR - https://www.unboundmedicine.com/medline/citation/24776962/The_comparison_of_thyroxine_versus_thyroxine_plus_oral_iodine_in_the_treatment_of_congenital_hypothyroidism_due_to_iodine_deficiency_ L2 - https://www.karger.com?DOI=10.1159/000358878 DB - PRIME DP - Unbound Medicine ER -