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A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations.

Abstract

OBJECTIVE

This nation-wide register-based study investigated how often anorexia nervosa (AN) and co-morbid disorders occur in affected families compared with control families. Furthermore, the study addressed the impact of sex, year of birth, and degree of urbanization in terms of risk factors.

METHOD

A total of N = 2,370 child and adolescent psychiatric subjects born between 1951 and 1996 and registered in the Danish Psychiatric Central Research Register (DPCRR) had any mental disorder before the age of 18 and developed AN at some point during their life-time. In addition, N = 7,035 controls without any psychiatric diagnosis before age 18 and matched for age, sex, and residential region were included. Psychiatric diagnoses were also obtained on the first-degree relatives as a part of the Danish Three Generation Study (3GS). A family load component was obtained by using various mixed regression models.

RESULTS

AN occurred significantly more often in case than in control families. AN Risk factors included having a sibling with AN, affective disorders in family members, and co-morbid affective, anxiety, obsessive-compulsive, personality, or substance use disorders. Furthermore, female sex, and ascending year of birth were significantly associated with having AN. Urbanization was not related to the family load of AN and case-relatives did not develop AN earlier than control relatives.

DISCUSSION

These findings based on a very large and representative dataset provide evidence for the family aggregation and further risk factors in AN.

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  • Authors+Show Affiliations

    ,

    Research Unit for Child and Adolescent Psychiatry, Psychiatric Hospital, Aalborg University Hospital, Aalborg, Denmark; Clinical Psychology and Epidemiology, Institute of Psychology, University of Basel, Switzerland; Department of Child and Adolescent Psychiatry, University of Zurich, Switzerland.

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Anorexia Nervosa
    Anxiety Disorders
    Case-Control Studies
    Comorbidity
    Denmark
    Family
    Female
    Humans
    Logistic Models
    Male
    Mental Disorders
    Middle Aged
    Personality Disorders
    Registries
    Risk Factors
    Siblings
    Substance-Related Disorders
    Urbanization

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24777686

    Citation

    Steinhausen, Hans-Christoph, et al. "A Nation-wide Study of the Family Aggregation and Risk Factors in Anorexia Nervosa Over Three Generations." The International Journal of Eating Disorders, vol. 48, no. 1, 2015, pp. 1-8.
    Steinhausen HC, Jakobsen H, Helenius D, et al. A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations. Int J Eat Disord. 2015;48(1):1-8.
    Steinhausen, H. C., Jakobsen, H., Helenius, D., Munk-Jørgensen, P., & Strober, M. (2015). A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations. The International Journal of Eating Disorders, 48(1), pp. 1-8. doi:10.1002/eat.22293.
    Steinhausen HC, et al. A Nation-wide Study of the Family Aggregation and Risk Factors in Anorexia Nervosa Over Three Generations. Int J Eat Disord. 2015;48(1):1-8. PubMed PMID: 24777686.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations. AU - Steinhausen,Hans-Christoph, AU - Jakobsen,Helle, AU - Helenius,Dorte, AU - Munk-Jørgensen,Povl, AU - Strober,Michael, Y1 - 2014/04/29/ PY - 2014/02/28/received PY - 2014/04/09/revised PY - 2014/04/17/accepted PY - 2014/4/30/entrez PY - 2014/4/30/pubmed PY - 2015/5/9/medline KW - anorexia nervosa KW - early onset KW - family based register study SP - 1 EP - 8 JF - The International journal of eating disorders JO - Int J Eat Disord VL - 48 IS - 1 N2 - OBJECTIVE: This nation-wide register-based study investigated how often anorexia nervosa (AN) and co-morbid disorders occur in affected families compared with control families. Furthermore, the study addressed the impact of sex, year of birth, and degree of urbanization in terms of risk factors. METHOD: A total of N = 2,370 child and adolescent psychiatric subjects born between 1951 and 1996 and registered in the Danish Psychiatric Central Research Register (DPCRR) had any mental disorder before the age of 18 and developed AN at some point during their life-time. In addition, N = 7,035 controls without any psychiatric diagnosis before age 18 and matched for age, sex, and residential region were included. Psychiatric diagnoses were also obtained on the first-degree relatives as a part of the Danish Three Generation Study (3GS). A family load component was obtained by using various mixed regression models. RESULTS: AN occurred significantly more often in case than in control families. AN Risk factors included having a sibling with AN, affective disorders in family members, and co-morbid affective, anxiety, obsessive-compulsive, personality, or substance use disorders. Furthermore, female sex, and ascending year of birth were significantly associated with having AN. Urbanization was not related to the family load of AN and case-relatives did not develop AN earlier than control relatives. DISCUSSION: These findings based on a very large and representative dataset provide evidence for the family aggregation and further risk factors in AN. SN - 1098-108X UR - https://www.unboundmedicine.com/medline/citation/24777686/full_citation L2 - https://doi.org/10.1002/eat.22293 DB - PRIME DP - Unbound Medicine ER -