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Nonspecific Interstitial pneumonia (NSIP)/ Overlap or Distinct Entity: A case report from the National Research Institute of Tuberculosis and Lung Disease (NRITLD).
Caspian J Intern Med. 2014 Spring; 5(2):118-22.CJ

Abstract

BACKGROUND

In many cases of ILD (interstitial lung disease), overlap diagnosis is considered. Here, a few cases with diagnosis of a variety of ILDs, where eventual open lung biopsy has been performed are selected. Reference will be made to reliable sources to show that NSIP can still be a variant of UIP (Usual interstitial pneumonia) with better treatment response and prognosis.

CASE PRESENTATION

In case 1, there is a difference between the HRCT(High Resolution Computed Tomography) result (NSIP pattern without fibrosis) and pathologic result (which includes fibrosing NSIP more closely related to UIP).Case 2 shows obvious discord between HRCT result (UIP pattern) and pathologic result (NSIP pattern). In case 3, there is again a discrepancy between HRCT report (very mild architectural distortion suggestive for ILD like NSIP) and pathology report (destructed lung tissue with interstitial fibrosis suggestive of HP (Hypersesitivity Pneumonitis) and not NSIP.

CONCLUSION

In this paper, we demonstrate that although NSIP can be a distinct diagnosis in most cases, but in rare cases the distinction between the other kinds of ILD especially UIP and NSIP in spite of full workup including tissue assessment can be very difficult.

Authors+Show Affiliations

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Nursing and Respiratory Health Management Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences,Tehran, Iran.Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

24778789

Citation

Mehrian, Payam, et al. "Nonspecific Interstitial Pneumonia (NSIP)/ Overlap or Distinct Entity: a Case Report From the National Research Institute of Tuberculosis and Lung Disease (NRITLD)." Caspian Journal of Internal Medicine, vol. 5, no. 2, 2014, pp. 118-22.
Mehrian P, Cheraghvandi A, Droudnia A, et al. Nonspecific Interstitial pneumonia (NSIP)/ Overlap or Distinct Entity: A case report from the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Caspian J Intern Med. 2014;5(2):118-22.
Mehrian, P., Cheraghvandi, A., Droudnia, A., Talischi, F., Fallah Tafti, S., Kahkouee, S., & Jamaati, H. (2014). Nonspecific Interstitial pneumonia (NSIP)/ Overlap or Distinct Entity: A case report from the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Caspian Journal of Internal Medicine, 5(2), 118-22.
Mehrian P, et al. Nonspecific Interstitial Pneumonia (NSIP)/ Overlap or Distinct Entity: a Case Report From the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Caspian J Intern Med. 2014;5(2):118-22. PubMed PMID: 24778789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonspecific Interstitial pneumonia (NSIP)/ Overlap or Distinct Entity: A case report from the National Research Institute of Tuberculosis and Lung Disease (NRITLD). AU - Mehrian,Payam, AU - Cheraghvandi,Ali, AU - Droudnia,Atousa, AU - Talischi,Firouzeh, AU - Fallah Tafti,Saeid, AU - Kahkouee,Shahram, AU - Jamaati,Hamidreza, PY - 2013/08/22/received PY - 2013/12/12/revised PY - 2014/01/01/accepted PY - 2014/4/30/entrez PY - 2014/4/30/pubmed PY - 2014/4/30/medline KW - Computed tomography KW - Interstitial Pneumonia; Diagnosis KW - Lung Diseases SP - 118 EP - 22 JF - Caspian journal of internal medicine JO - Caspian J Intern Med VL - 5 IS - 2 N2 - BACKGROUND: In many cases of ILD (interstitial lung disease), overlap diagnosis is considered. Here, a few cases with diagnosis of a variety of ILDs, where eventual open lung biopsy has been performed are selected. Reference will be made to reliable sources to show that NSIP can still be a variant of UIP (Usual interstitial pneumonia) with better treatment response and prognosis. CASE PRESENTATION: In case 1, there is a difference between the HRCT(High Resolution Computed Tomography) result (NSIP pattern without fibrosis) and pathologic result (which includes fibrosing NSIP more closely related to UIP).Case 2 shows obvious discord between HRCT result (UIP pattern) and pathologic result (NSIP pattern). In case 3, there is again a discrepancy between HRCT report (very mild architectural distortion suggestive for ILD like NSIP) and pathology report (destructed lung tissue with interstitial fibrosis suggestive of HP (Hypersesitivity Pneumonitis) and not NSIP. CONCLUSION: In this paper, we demonstrate that although NSIP can be a distinct diagnosis in most cases, but in rare cases the distinction between the other kinds of ILD especially UIP and NSIP in spite of full workup including tissue assessment can be very difficult. SN - 2008-6164 UR - https://www.unboundmedicine.com/medline/citation/24778789/Nonspecific_Interstitial_pneumonia__NSIP_/_Overlap_or_Distinct_Entity:_A_case_report_from_the_National_Research_Institute_of_Tuberculosis_and_Lung_Disease__NRITLD__ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24778789/ DB - PRIME DP - Unbound Medicine ER -
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