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[Immunomorphologic features of experimental allergic encephalomyelitis induced by the administration of tryptophan peptide].
Biull Eksp Biol Med. 1989 Aug; 108(8):241-4.BE

Abstract

Three patterns of EAE with different morbidity and mortality rates were induced in the guinea pigs inoculated with various doses of tryptophane peptide (TP) and complete Freund's adjuvant. TP-sensitized animals manifested the delayed type hypersensitivity (DTH) reactions to TP and circulating anti-TP and -BPF antibodies were not found, polypeptide fraction of myelin basic protein (BPF while a A correlation was revealed between the DTH-reactions and EAE development. Intracutaneous TP and BPF injections at the early period before the EAE onset resulted in reduction of morbidity rate from 90 to 50 per cent. For the first time with the help of modified Marchi method demyelination has been shown to be highly marked in CNS tissue process in CNS can be caused by cell-mediated immune of animals given TP. It is supposed that the demyelinating reaction to encephalitogenic fragment of BP molecule. The data indicate a possibility of EAE inhibition by means of TP and BPF injections in saline solution.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

2478215

Citation

Zhitnukhin, Iu L., and M G. Khizhniak. "[Immunomorphologic Features of Experimental Allergic Encephalomyelitis Induced By the Administration of Tryptophan Peptide]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 108, no. 8, 1989, pp. 241-4.
Zhitnukhin IuL, Khizhniak MG. [Immunomorphologic features of experimental allergic encephalomyelitis induced by the administration of tryptophan peptide]. Biull Eksp Biol Med. 1989;108(8):241-4.
Zhitnukhin, I. u. L., & Khizhniak, M. G. (1989). [Immunomorphologic features of experimental allergic encephalomyelitis induced by the administration of tryptophan peptide]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 108(8), 241-4.
Zhitnukhin IuL, Khizhniak MG. [Immunomorphologic Features of Experimental Allergic Encephalomyelitis Induced By the Administration of Tryptophan Peptide]. Biull Eksp Biol Med. 1989;108(8):241-4. PubMed PMID: 2478215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunomorphologic features of experimental allergic encephalomyelitis induced by the administration of tryptophan peptide]. AU - Zhitnukhin,Iu L, AU - Khizhniak,M G, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 241 EP - 4 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 108 IS - 8 N2 - Three patterns of EAE with different morbidity and mortality rates were induced in the guinea pigs inoculated with various doses of tryptophane peptide (TP) and complete Freund's adjuvant. TP-sensitized animals manifested the delayed type hypersensitivity (DTH) reactions to TP and circulating anti-TP and -BPF antibodies were not found, polypeptide fraction of myelin basic protein (BPF while a A correlation was revealed between the DTH-reactions and EAE development. Intracutaneous TP and BPF injections at the early period before the EAE onset resulted in reduction of morbidity rate from 90 to 50 per cent. For the first time with the help of modified Marchi method demyelination has been shown to be highly marked in CNS tissue process in CNS can be caused by cell-mediated immune of animals given TP. It is supposed that the demyelinating reaction to encephalitogenic fragment of BP molecule. The data indicate a possibility of EAE inhibition by means of TP and BPF injections in saline solution. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/2478215/[Immunomorphologic_features_of_experimental_allergic_encephalomyelitis_induced_by_the_administration_of_tryptophan_peptide]_ DB - PRIME DP - Unbound Medicine ER -