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Pancreatic effect of andrographolide isolated from Andrographis paniculata (Burm. f.) Nees.
Pak J Biol Sci. 2014 Jan 01; 17(1):22-31.PJ

Abstract

Andrographis paniculata (Burm. f.) Nees is a plant that originates from India and grows widely to Southeast which used for several purposes mainly as treatment of diabetes mellitus so the aim of this study was evaluate andrographolide for its pancreatic effect in neonatal streptozotocin (STZ)-induced diabetic rats, a model of type 2 diabetic rats. Diabetic condition was induced with an intraperitoneal injection of 90 mg kg(-1) streptozotocin in two-day-old rats. After three months, the neonatal STZ-induced diabetic rats were treated with andrographolide or andrographolide-enriched extract of A. paniculata (AEEAP) for 8 consecutive days. Pancreatic effect was evaluated by estimating mainly the preprandial and postprandial blood glucose levels and other parameters such as morphology of pancreatic islet, beta cells density and morphology and immunohistochemically pancreatic insulin. Andrographolide significantly (p < 0.05) decreased the levels of blood glucose and improved diabetic rat islet and beta cells. However, AEEAP exhibited moderate hypoglycaemic effects on the blood glucose levels. Moderate changes in beta cells were observed after AEEAP treatment. They could restore decreasing of pancreatic insulin contents. Based on these results andrographolide and AEEAP exhibited pancreatic actions in neonatal STZ-induced diabetic rats. The activity of andrographolide was more effective than this of AEEAP.

Authors

Nugroho AE
No affiliation info available
Rais IR
No affiliation info available
Setiawan I
No affiliation info available
Pratiwi PY
No affiliation info available
Hadibarata T
No affiliation info available
Tegar M
No affiliation info available
Pramono S
No affiliation info available

MeSH

AndrographisAnimalsBlood GlucoseDiabetes Mellitus, Type 2DiterpenesGene Expression RegulationHypoglycemic AgentsInsulinInsulin-Secreting CellsPancreasRats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24783774

Citation

Nugroho, Agung Endro, et al. "Pancreatic Effect of Andrographolide Isolated From Andrographis Paniculata (Burm. F.) Nees." Pakistan Journal of Biological Sciences : PJBS, vol. 17, no. 1, 2014, pp. 22-31.
Nugroho AE, Rais IR, Setiawan I, et al. Pancreatic effect of andrographolide isolated from Andrographis paniculata (Burm. f.) Nees. Pak J Biol Sci. 2014;17(1):22-31.
Nugroho, A. E., Rais, I. R., Setiawan, I., Pratiwi, P. Y., Hadibarata, T., Tegar, M., & Pramono, S. (2014). Pancreatic effect of andrographolide isolated from Andrographis paniculata (Burm. f.) Nees. Pakistan Journal of Biological Sciences : PJBS, 17(1), 22-31.
Nugroho AE, et al. Pancreatic Effect of Andrographolide Isolated From Andrographis Paniculata (Burm. F.) Nees. Pak J Biol Sci. 2014 Jan 1;17(1):22-31. PubMed PMID: 24783774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic effect of andrographolide isolated from Andrographis paniculata (Burm. f.) Nees. AU - Nugroho,Agung Endro, AU - Rais,Ichwan Ridwan, AU - Setiawan,Iwan, AU - Pratiwi,Pramita Yuli, AU - Hadibarata,Tony, AU - Tegar,Maulana, AU - Pramono,Suwidjiyo, PY - 2014/5/3/entrez PY - 2014/5/3/pubmed PY - 2014/5/23/medline SP - 22 EP - 31 JF - Pakistan journal of biological sciences : PJBS JO - Pak J Biol Sci VL - 17 IS - 1 N2 - Andrographis paniculata (Burm. f.) Nees is a plant that originates from India and grows widely to Southeast which used for several purposes mainly as treatment of diabetes mellitus so the aim of this study was evaluate andrographolide for its pancreatic effect in neonatal streptozotocin (STZ)-induced diabetic rats, a model of type 2 diabetic rats. Diabetic condition was induced with an intraperitoneal injection of 90 mg kg(-1) streptozotocin in two-day-old rats. After three months, the neonatal STZ-induced diabetic rats were treated with andrographolide or andrographolide-enriched extract of A. paniculata (AEEAP) for 8 consecutive days. Pancreatic effect was evaluated by estimating mainly the preprandial and postprandial blood glucose levels and other parameters such as morphology of pancreatic islet, beta cells density and morphology and immunohistochemically pancreatic insulin. Andrographolide significantly (p < 0.05) decreased the levels of blood glucose and improved diabetic rat islet and beta cells. However, AEEAP exhibited moderate hypoglycaemic effects on the blood glucose levels. Moderate changes in beta cells were observed after AEEAP treatment. They could restore decreasing of pancreatic insulin contents. Based on these results andrographolide and AEEAP exhibited pancreatic actions in neonatal STZ-induced diabetic rats. The activity of andrographolide was more effective than this of AEEAP. SN - 1028-8880 UR - https://www.unboundmedicine.com/medline/citation/24783774/Pancreatic_effect_of_andrographolide_isolated_from_Andrographis_paniculata__Burm__f___Nees_ DB - PRIME DP - Unbound Medicine ER -
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