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Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children.
Epidemiol Infect 2015; 143(3):540-9EI

Abstract

We examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations.

Authors+Show Affiliations

Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.Department of Ecology and Evolutionary Biology,Princeton University,Princeton, NJ,USA.Division of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.Division of Community Medicine and Public Health Practice, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.Division of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24786933

Citation

Freeman, G, et al. "Multivariate Analysis of Factors Affecting the Immunogenicity of Trivalent Inactivated Influenza Vaccine in School-age Children." Epidemiology and Infection, vol. 143, no. 3, 2015, pp. 540-9.
Freeman G, Ng S, Perera RA, et al. Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children. Epidemiol Infect. 2015;143(3):540-9.
Freeman, G., Ng, S., Perera, R. A., Fang, V. J., Ip, D. K., Leung, G. M., ... Cowling, B. J. (2015). Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children. Epidemiology and Infection, 143(3), pp. 540-9. doi:10.1017/S0950268814000855.
Freeman G, et al. Multivariate Analysis of Factors Affecting the Immunogenicity of Trivalent Inactivated Influenza Vaccine in School-age Children. Epidemiol Infect. 2015;143(3):540-9. PubMed PMID: 24786933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children. AU - Freeman,G, AU - Ng,S, AU - Perera,R A P M, AU - Fang,V J, AU - Ip,D K M, AU - Leung,G M, AU - Peiris,J S M, AU - Cowling,B J, Y1 - 2014/05/01/ PY - 2014/5/3/entrez PY - 2014/5/3/pubmed PY - 2015/3/15/medline KW - Immunization (vaccination) KW - influenza KW - serology KW - statistics SP - 540 EP - 9 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 143 IS - 3 N2 - We examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/24786933/Multivariate_analysis_of_factors_affecting_the_immunogenicity_of_trivalent_inactivated_influenza_vaccine_in_school_age_children_ L2 - https://www.cambridge.org/core/product/identifier/S0950268814000855/type/journal_article DB - PRIME DP - Unbound Medicine ER -