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Seasonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status.
J Pediatr Gastroenterol Nutr. 2014 May; 58(5):654-60.JP

Abstract

OBJECTIVES

The aim of the study was to assess seasonal prevalence of vitamin D deficiency according to sex and to determine the relations between serum levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) and sociodemographic characteristics in otherwise healthy schoolchildren during spring and autumn.

METHODS

In a cross-sectional study, 746 healthy students aged between 11 and 18 years were recruited during spring (n = 375) and autumn (n = 371). Sociodemographic data were collected by a questionnaire. Serum 25(OH)D, PTH, calcium, phosphate, and alkaline phosphatase were measured. Serum 25(OH)D levels were categorized as <50 nmol/L (vitamin D deficiency) and <25 nmol/L (severe deficiency).

RESULTS

Mean ± standard deviation 25(OH)D levels were 22.3 ± 10.5 nmol/L in girls and 28.5 ± 17.0 nmol/L in boys during spring (P < 0.001) and 36.5 ± 20.3 nmol/L in girls and 45.0 ± 18.5 nmol/L in boys during autumn (P < 0.001). The prevalence of vitamin D deficiency was 93% during spring and 71% during autumn. There was a negative correlation between 25(OH)D and PTH levels (P < 0.01). We determined a cutoff point of serum 25(OH)D in which the mean serum PTH concentration began to increase as 35.8 nmol/L (P < 0.0001). The age, sex, and calcium level were found to be independent predictors for vitamin D deficiency.

CONCLUSIONS

Vitamin D deficiency is prevalent among healthy schoolchildren. It is noteworthy that 25(OH)D levels were significantly lower in girls and during autumn. We recommend vitamin D supplementation for children in addition to more time spent for outdoor activities for sensible sunlight exposure.

Authors+Show Affiliations

*Department of Pediatric Endocrinology †Department of Pediatrics, School of Medicine ‡Department of Public Health §Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey ||Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition and Diabetes, Department of Medicine, Boston University Medical Center, Boston, MA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24787093

Citation

Karagüzel, Gülay, et al. "Seasonal Vitamin D Status of Healthy Schoolchildren and Predictors of Low Vitamin D Status." Journal of Pediatric Gastroenterology and Nutrition, vol. 58, no. 5, 2014, pp. 654-60.
Karagüzel G, Dilber B, Çan G, et al. Seasonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status. J Pediatr Gastroenterol Nutr. 2014;58(5):654-60.
Karagüzel, G., Dilber, B., Çan, G., Ökten, A., Değer, O., & Holick, M. F. (2014). Seasonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status. Journal of Pediatric Gastroenterology and Nutrition, 58(5), 654-60. https://doi.org/10.1097/MPG.0000000000000274
Karagüzel G, et al. Seasonal Vitamin D Status of Healthy Schoolchildren and Predictors of Low Vitamin D Status. J Pediatr Gastroenterol Nutr. 2014;58(5):654-60. PubMed PMID: 24787093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seasonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status. AU - Karagüzel,Gülay, AU - Dilber,Beril, AU - Çan,Gamze, AU - Ökten,Ayşenur, AU - Değer,Orhan, AU - Holick,Michael F, PY - 2014/5/3/entrez PY - 2014/5/3/pubmed PY - 2014/12/24/medline SP - 654 EP - 60 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 58 IS - 5 N2 - OBJECTIVES: The aim of the study was to assess seasonal prevalence of vitamin D deficiency according to sex and to determine the relations between serum levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) and sociodemographic characteristics in otherwise healthy schoolchildren during spring and autumn. METHODS: In a cross-sectional study, 746 healthy students aged between 11 and 18 years were recruited during spring (n = 375) and autumn (n = 371). Sociodemographic data were collected by a questionnaire. Serum 25(OH)D, PTH, calcium, phosphate, and alkaline phosphatase were measured. Serum 25(OH)D levels were categorized as <50 nmol/L (vitamin D deficiency) and <25 nmol/L (severe deficiency). RESULTS: Mean ± standard deviation 25(OH)D levels were 22.3 ± 10.5 nmol/L in girls and 28.5 ± 17.0 nmol/L in boys during spring (P < 0.001) and 36.5 ± 20.3 nmol/L in girls and 45.0 ± 18.5 nmol/L in boys during autumn (P < 0.001). The prevalence of vitamin D deficiency was 93% during spring and 71% during autumn. There was a negative correlation between 25(OH)D and PTH levels (P < 0.01). We determined a cutoff point of serum 25(OH)D in which the mean serum PTH concentration began to increase as 35.8 nmol/L (P < 0.0001). The age, sex, and calcium level were found to be independent predictors for vitamin D deficiency. CONCLUSIONS: Vitamin D deficiency is prevalent among healthy schoolchildren. It is noteworthy that 25(OH)D levels were significantly lower in girls and during autumn. We recommend vitamin D supplementation for children in addition to more time spent for outdoor activities for sensible sunlight exposure. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/24787093/Seasonal_vitamin_D_status_of_healthy_schoolchildren_and_predictors_of_low_vitamin_D_status_ L2 - https://doi.org/10.1097/MPG.0000000000000274 DB - PRIME DP - Unbound Medicine ER -