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The relationship between IL-10 levels and cardiovascular events in patients with CKD.
Clin J Am Soc Nephrol. 2014 Jul; 9(7):1207-16.CJ

Abstract

BACKGROUND AND OBJECTIVES

Cardiovascular disease is the leading cause of death in patients with CKD. IL-10 is considered an antiatherosclerotic cytokine. However, previous studies have failed to observe an association between IL-10 and cardiovascular disease in CKD. This study aimed to evaluate whether serum IL-10 levels were associated with the risk of cardiovascular events in CKD patients.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

Four hundred three patients with stages 1-5 CKD were followed for a mean of 38 (range=2-42) months for fatal and nonfatal cardiovascular events. IL-10 and IL-6 were measured at baseline together with surrogates of endothelial function (flow-mediated dilatation) and proinflammatory markers (high-sensitivity C-reactive protein and pentraxin-3). The association between IL-10 and flow-mediated dilatation through linear regression analyses was evaluated. The association between IL-10 and the risk of cardiovascular events was assessed with Cox regression analysis.

RESULTS

IL-10, IL-6, high-sensitivity C-reactive protein, and pentraxin-3 levels were higher among participants with lower eGFR. Both fatal (25 of 200 versus 6 of 203 patients) and combined fatal and nonfatal (106 of 200 versus 23 of 203 patients) cardiovascular events were more common in patients with IL-10 concentration above the median. Flow-mediated dilatation was significantly lower in patients with higher serum IL-10 levels, but IL-10 was not associated with flow-mediated dilatation in multivariate analysis. Kaplan-Meier survival curves showed that patients with IL-10 below the median value (<21.5 pg/ml) had higher cumulative survival compared with patients who had IL-10 levels above the median value (log-rank test, P<0.001).

CONCLUSIONS

IL-10 levels increase along with the reduction of kidney function. Higher serum IL-10 levels were associated with the risk of cardiovascular events during follow-up. We speculate that higher IL-10 levels in this context signify an overall proinflammatory milieu.

Authors+Show Affiliations

Departments of Nephrology.Department of Medicine, Division of Nephrology, Karaman State Hospital, Karaman, Turkey;Radiology.Biochemistry, and.Epidemiology, Gülhane School of Medicine, Ankara, Turkey;Departments of Nephrology.Departments of Nephrology.Departments of Nephrology.Radiology.Department of Medicine, Division of Renal Medicine andCentres for Molecular Medicine and Gender Medicine, Karolinska Institute, Stockholm, Sweden;Department of Medicine, Division of Renal Medicine and.Nephrology Clinic, Dialysis and Renal Transplant Center, C.I. PARHON University Hospital and Grigore T. Popa University of Medicine, Iasi, Romania; and.Department of Medicine, Division of Nephrology, İstanbul Medeniyet University School of Medicine, Istanbul, Turkey drkanbay@yahoo.com.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24789549

Citation

Yilmaz, Mahmut Ilker, et al. "The Relationship Between IL-10 Levels and Cardiovascular Events in Patients With CKD." Clinical Journal of the American Society of Nephrology : CJASN, vol. 9, no. 7, 2014, pp. 1207-16.
Yilmaz MI, Solak Y, Saglam M, et al. The relationship between IL-10 levels and cardiovascular events in patients with CKD. Clin J Am Soc Nephrol. 2014;9(7):1207-16.
Yilmaz, M. I., Solak, Y., Saglam, M., Cayci, T., Acikel, C., Unal, H. U., Eyileten, T., Oguz, Y., Sari, S., Carrero, J. J., Stenvinkel, P., Covic, A., & Kanbay, M. (2014). The relationship between IL-10 levels and cardiovascular events in patients with CKD. Clinical Journal of the American Society of Nephrology : CJASN, 9(7), 1207-16. https://doi.org/10.2215/CJN.08660813
Yilmaz MI, et al. The Relationship Between IL-10 Levels and Cardiovascular Events in Patients With CKD. Clin J Am Soc Nephrol. 2014;9(7):1207-16. PubMed PMID: 24789549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between IL-10 levels and cardiovascular events in patients with CKD. AU - Yilmaz,Mahmut Ilker, AU - Solak,Yalcin, AU - Saglam,Mutlu, AU - Cayci,Tuncer, AU - Acikel,Cengizhan, AU - Unal,Hilmi Umut, AU - Eyileten,Tayfun, AU - Oguz,Yusuf, AU - Sari,Sebahattin, AU - Carrero,Juan Jesus, AU - Stenvinkel,Peter, AU - Covic,Adrian, AU - Kanbay,Mehmet, Y1 - 2014/05/01/ PY - 2014/5/3/entrez PY - 2014/5/3/pubmed PY - 2015/4/7/medline KW - CKD KW - IL-10 KW - cardiovascular disease KW - kidney disease SP - 1207 EP - 16 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 9 IS - 7 N2 - BACKGROUND AND OBJECTIVES: Cardiovascular disease is the leading cause of death in patients with CKD. IL-10 is considered an antiatherosclerotic cytokine. However, previous studies have failed to observe an association between IL-10 and cardiovascular disease in CKD. This study aimed to evaluate whether serum IL-10 levels were associated with the risk of cardiovascular events in CKD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Four hundred three patients with stages 1-5 CKD were followed for a mean of 38 (range=2-42) months for fatal and nonfatal cardiovascular events. IL-10 and IL-6 were measured at baseline together with surrogates of endothelial function (flow-mediated dilatation) and proinflammatory markers (high-sensitivity C-reactive protein and pentraxin-3). The association between IL-10 and flow-mediated dilatation through linear regression analyses was evaluated. The association between IL-10 and the risk of cardiovascular events was assessed with Cox regression analysis. RESULTS: IL-10, IL-6, high-sensitivity C-reactive protein, and pentraxin-3 levels were higher among participants with lower eGFR. Both fatal (25 of 200 versus 6 of 203 patients) and combined fatal and nonfatal (106 of 200 versus 23 of 203 patients) cardiovascular events were more common in patients with IL-10 concentration above the median. Flow-mediated dilatation was significantly lower in patients with higher serum IL-10 levels, but IL-10 was not associated with flow-mediated dilatation in multivariate analysis. Kaplan-Meier survival curves showed that patients with IL-10 below the median value (<21.5 pg/ml) had higher cumulative survival compared with patients who had IL-10 levels above the median value (log-rank test, P<0.001). CONCLUSIONS: IL-10 levels increase along with the reduction of kidney function. Higher serum IL-10 levels were associated with the risk of cardiovascular events during follow-up. We speculate that higher IL-10 levels in this context signify an overall proinflammatory milieu. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/24789549/The_relationship_between_IL_10_levels_and_cardiovascular_events_in_patients_with_CKD_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=24789549 DB - PRIME DP - Unbound Medicine ER -