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A spectrum of clinical presentations in seven Japanese patients with vitamin d deficiency.
Clin Pediatr Endocrinol 2006; 15(1):23-8CP

Abstract

Recently, the reemergence of vitamin D deficiency in developed countries has been pointed out. Vitamin D deficiency is diagnosed based on the serum 25-hydroxyvitamin D (25OHD) level. However, its normal range is still controversial, making the diagnosis of vitamin D deficiency difficult. Here, we present seven Japanese patients diagnosed with vitamin D deficiency. Three patients complained of leg bowing, and the other four of tetany. The patients with leg bowing were toddlers. Radiographic surveys demonstrated evidence of rickets. Laboratory findings showed decreased levels of serum inorganic phosphorus and increased levels of alkaline phosphatase (ALP) and intact-parathyroid hormone (iPTH). The serum levels of 25OHD were relatively low, ranging from 13 to 15.2 ng/ml. Of the patients with tetany, three were young infants. Laboratory findings showed decreased levels of serum calcium and increased levels of ALP and iPTH. The serum levels of 25OHD were markedly decreased (below 8 ng/ml). Thus, these results indicate that relatively low levels of 25OHD can cause rickets, a symptom of vitamin D deficiency, and that clinicians should therefore carefully evaluate the levels of 25OHD.

Authors+Show Affiliations

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Pediatrics, Toyonaka Municipal Hospital, Osaka, Japan.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan ; The First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan.Department of Pediatrics, NTT West Osaka Hospital, Osaka, Japan.Department of Pediatrics, Toyonaka Municipal Hospital, Osaka, Japan.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24790316

Citation

Kubota, Takuo, et al. "A Spectrum of Clinical Presentations in Seven Japanese Patients With Vitamin D Deficiency." Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology, vol. 15, no. 1, 2006, pp. 23-8.
Kubota T, Kotani T, Miyoshi Y, et al. A spectrum of clinical presentations in seven Japanese patients with vitamin d deficiency. Clin Pediatr Endocrinol. 2006;15(1):23-8.
Kubota, T., Kotani, T., Miyoshi, Y., Santo, Y., Hirai, H., Namba, N., ... Ozono, K. (2006). A spectrum of clinical presentations in seven Japanese patients with vitamin d deficiency. Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology, 15(1), pp. 23-8. doi:10.1297/cpe.15.23.
Kubota T, et al. A Spectrum of Clinical Presentations in Seven Japanese Patients With Vitamin D Deficiency. Clin Pediatr Endocrinol. 2006;15(1):23-8. PubMed PMID: 24790316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A spectrum of clinical presentations in seven Japanese patients with vitamin d deficiency. AU - Kubota,Takuo, AU - Kotani,Tomoo, AU - Miyoshi,Yoko, AU - Santo,Yoko, AU - Hirai,Haruhiko, AU - Namba,Noriyuki, AU - Shima,Masaaki, AU - Shimizu,Kazuo, AU - Nakajima,Shigeo, AU - Ozono,Keiichi, Y1 - 2006/02/22/ PY - 2005/06/22/received PY - 2005/09/20/accepted PY - 2014/5/3/entrez PY - 2006/1/1/pubmed PY - 2006/1/1/medline KW - 25-hydroxyvitamin D KW - Vitamin D deficiency KW - hypocalcemia KW - rickets SP - 23 EP - 8 JF - Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology JO - Clin Pediatr Endocrinol VL - 15 IS - 1 N2 - Recently, the reemergence of vitamin D deficiency in developed countries has been pointed out. Vitamin D deficiency is diagnosed based on the serum 25-hydroxyvitamin D (25OHD) level. However, its normal range is still controversial, making the diagnosis of vitamin D deficiency difficult. Here, we present seven Japanese patients diagnosed with vitamin D deficiency. Three patients complained of leg bowing, and the other four of tetany. The patients with leg bowing were toddlers. Radiographic surveys demonstrated evidence of rickets. Laboratory findings showed decreased levels of serum inorganic phosphorus and increased levels of alkaline phosphatase (ALP) and intact-parathyroid hormone (iPTH). The serum levels of 25OHD were relatively low, ranging from 13 to 15.2 ng/ml. Of the patients with tetany, three were young infants. Laboratory findings showed decreased levels of serum calcium and increased levels of ALP and iPTH. The serum levels of 25OHD were markedly decreased (below 8 ng/ml). Thus, these results indicate that relatively low levels of 25OHD can cause rickets, a symptom of vitamin D deficiency, and that clinicians should therefore carefully evaluate the levels of 25OHD. SN - 0918-5739 UR - https://www.unboundmedicine.com/medline/citation/24790316/A_spectrum_of_clinical_presentations_in_seven_Japanese_patients_with_vitamin_d_deficiency_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24790316/ DB - PRIME DP - Unbound Medicine ER -