Tags

Type your tag names separated by a space and hit enter

Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis.
Osteoarthritis Cartilage. 2014 Jun; 22(6):718-25.OC

Abstract

OBJECTIVE

To assess the efficacy and safety of intra-articular hyaluronic acid (IAHA) injection in knee joints of patients with Kashin-Beck disease (KBD).

METHODS

We searched nine electronic databases as well as unpublished data from inception until November 30th 2013 using a combination of search terms for KBD and hyaluronic acid (HA). For dichotomous data, odds ratios (OR) and 95% confidence intervals (CI) were estimated. For continuous data, standard mean difference (SMD) was used for outcomes pooled on the difference scale using a "random-effects" or "fixed-effects" model. We also compared the mean and standard deviation of cytokine levels in post-treatment.

RESULTS

The seven eligible trials included 954 IAHA and 495 control patients. The methodological quality of included trials was low. The overall effectiveness of the IAHA group and control group were 93.7% and 62.9%, respectively. IAHA group resulted in very large treatment effects compared to pre-treatment values in 12 months, with SMD values ranging from 1.19-2.64 (all P < 0.05). Compared to controls, SMDs in IAHA group ranged from 0.19-0.64 at 1 week to 1 month (all P > 0.05) and 0.68-1.47 at 2 months to 12 months (all P < 0.05). There was significant improved of HA, cluster of differentiation44 (CD44), keratan sulfate (KS), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) contents in serum compared with that in the post-treatment and healthy control in non-KBD area (all P < 0.05).

CONCLUSION

IAHA for the treatment of KBD was safe and efficacious at 12 months with low and transient adverse reactions. However, more high-quality randomized controlled trials (RCTs) are needed to confirm its therapeutic effect.

Authors+Show Affiliations

Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China.Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China. Electronic address: guox@mail.xjtu.edu.cn.

Pub Type(s)

Evaluation Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24792210

Citation

Yu, F F., et al. "Evaluation of the Therapeutic Effect of Treatment With Intra-articular Hyaluronic Acid in Knees for Kashin-Beck Disease: a Meta-analysis." Osteoarthritis and Cartilage, vol. 22, no. 6, 2014, pp. 718-25.
Yu FF, Xia CT, Fang H, et al. Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis. Osteoarthr Cartil. 2014;22(6):718-25.
Yu, F. F., Xia, C. T., Fang, H., Han, J., Younus, M. I., & Guo, X. (2014). Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis. Osteoarthritis and Cartilage, 22(6), 718-25. https://doi.org/10.1016/j.joca.2014.04.012
Yu FF, et al. Evaluation of the Therapeutic Effect of Treatment With Intra-articular Hyaluronic Acid in Knees for Kashin-Beck Disease: a Meta-analysis. Osteoarthr Cartil. 2014;22(6):718-25. PubMed PMID: 24792210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis. AU - Yu,F F, AU - Xia,C T, AU - Fang,H, AU - Han,J, AU - Younus,M I, AU - Guo,X, Y1 - 2014/04/30/ PY - 2014/01/16/received PY - 2014/04/01/revised PY - 2014/04/16/accepted PY - 2014/5/6/entrez PY - 2014/5/6/pubmed PY - 2015/1/27/medline KW - Intra-articular hyaluronic acid (IAHA) KW - Kashin-Beck disease (KBD) KW - Meta-analysis SP - 718 EP - 25 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 22 IS - 6 N2 - OBJECTIVE: To assess the efficacy and safety of intra-articular hyaluronic acid (IAHA) injection in knee joints of patients with Kashin-Beck disease (KBD). METHODS: We searched nine electronic databases as well as unpublished data from inception until November 30th 2013 using a combination of search terms for KBD and hyaluronic acid (HA). For dichotomous data, odds ratios (OR) and 95% confidence intervals (CI) were estimated. For continuous data, standard mean difference (SMD) was used for outcomes pooled on the difference scale using a "random-effects" or "fixed-effects" model. We also compared the mean and standard deviation of cytokine levels in post-treatment. RESULTS: The seven eligible trials included 954 IAHA and 495 control patients. The methodological quality of included trials was low. The overall effectiveness of the IAHA group and control group were 93.7% and 62.9%, respectively. IAHA group resulted in very large treatment effects compared to pre-treatment values in 12 months, with SMD values ranging from 1.19-2.64 (all P < 0.05). Compared to controls, SMDs in IAHA group ranged from 0.19-0.64 at 1 week to 1 month (all P > 0.05) and 0.68-1.47 at 2 months to 12 months (all P < 0.05). There was significant improved of HA, cluster of differentiation44 (CD44), keratan sulfate (KS), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) contents in serum compared with that in the post-treatment and healthy control in non-KBD area (all P < 0.05). CONCLUSION: IAHA for the treatment of KBD was safe and efficacious at 12 months with low and transient adverse reactions. However, more high-quality randomized controlled trials (RCTs) are needed to confirm its therapeutic effect. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/24792210/Evaluation_of_the_therapeutic_effect_of_treatment_with_intra_articular_hyaluronic_acid_in_knees_for_Kashin_Beck_disease:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(14)01050-4 DB - PRIME DP - Unbound Medicine ER -