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Outdoor air pollution and asthma.
Lancet. 2014 May 03; 383(9928):1581-92.Lct

Abstract

Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this Series paper, we discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. We focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. We also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma.

Authors+Show Affiliations

Department of Medicine, University of California, San Francisco, CA, USA; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.Department of Medicine, University of California, San Francisco, CA, USA; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA. Electronic address: jbalmes@medsfgh.ucsf.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24792855

Citation

Guarnieri, Michael, and John R. Balmes. "Outdoor Air Pollution and Asthma." Lancet (London, England), vol. 383, no. 9928, 2014, pp. 1581-92.
Guarnieri M, Balmes JR. Outdoor air pollution and asthma. Lancet. 2014;383(9928):1581-92.
Guarnieri, M., & Balmes, J. R. (2014). Outdoor air pollution and asthma. Lancet (London, England), 383(9928), 1581-92. https://doi.org/10.1016/S0140-6736(14)60617-6
Guarnieri M, Balmes JR. Outdoor Air Pollution and Asthma. Lancet. 2014 May 3;383(9928):1581-92. PubMed PMID: 24792855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outdoor air pollution and asthma. AU - Guarnieri,Michael, AU - Balmes,John R, PY - 2014/5/6/entrez PY - 2014/5/6/pubmed PY - 2014/5/23/medline SP - 1581 EP - 92 JF - Lancet (London, England) JO - Lancet VL - 383 IS - 9928 N2 - Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this Series paper, we discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. We focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. We also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/24792855/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60617-6 DB - PRIME DP - Unbound Medicine ER -