Tags

Type your tag names separated by a space and hit enter

Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials.
Neuroimage 2014; 98:225-32N

Abstract

The neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) have been mostly investigated by peripheral motor-evoked potentials (MEPs). New TMS-compatible EEG systems allow a direct investigation of the stimulation effects through the analysis of TMS-evoked potentials (TEPs). We investigated the effects of 1-Hz rTMS over the primary motor cortex (M1) of 15 healthy volunteers on TEP evoked by single pulse TMS over the same area. A second experiment in which rTMS was delivered over the primary visual cortex (V1) of 15 healthy volunteers was conducted to examine the spatial specificity of the effects. Single-pulse TMS evoked four main components: P30, N45, P60 and N100. M1-rTMS resulted in a significant decrease of MEP amplitude and in a significant increase of P60 and N100 amplitude. There was no effect after V1-rTMS. 1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials. Our results confirm the reliability of the TMS-evoked N100 as a marker of cortical inhibition and provide insight into the neuromodulatory effects of 1-Hz rTMS. The present finding could be of relevance for therapeutic and diagnostic purposes.

Authors+Show Affiliations

Lifespan Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, Via Venezia 8, Padua 35131, Italy; Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square 33, London WC1N 3BG, UK. Electronic address: eliasc@live.it.Lifespan Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, Via Venezia 8, Padua 35131, Italy.Faculty of Education, Free University of Bozen-Bolzano, Viale Ratisbona 16, 39042 Bressanone-Brixen, Italy; Centro di Neuroscienze Cognitive Applicate, Via Caio Manilio 30, Rome 00174, Italy.Lifespan Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, Via Venezia 8, Padua 35131, Italy.Lifespan Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, Via Venezia 8, Padua 35131, Italy.Department of Information Engineering, University of Padua, Via Gradenigo 6/B, Padua 35131, Italy.Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square 33, London WC1N 3BG, UK.Lifespan Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, Via Venezia 8, Padua 35131, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24793831

Citation

Casula, Elias P., et al. "Low-frequency rTMS Inhibitory Effects in the Primary Motor Cortex: Insights From TMS-evoked Potentials." NeuroImage, vol. 98, 2014, pp. 225-32.
Casula EP, Tarantino V, Basso D, et al. Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials. Neuroimage. 2014;98:225-32.
Casula, E. P., Tarantino, V., Basso, D., Arcara, G., Marino, G., Toffolo, G. M., ... Bisiacchi, P. S. (2014). Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials. NeuroImage, 98, pp. 225-32. doi:10.1016/j.neuroimage.2014.04.065.
Casula EP, et al. Low-frequency rTMS Inhibitory Effects in the Primary Motor Cortex: Insights From TMS-evoked Potentials. Neuroimage. 2014;98:225-32. PubMed PMID: 24793831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials. AU - Casula,Elias P, AU - Tarantino,Vincenza, AU - Basso,Demis, AU - Arcara,Giorgio, AU - Marino,Giuliana, AU - Toffolo,Gianna Maria, AU - Rothwell,John C, AU - Bisiacchi,Patrizia S, Y1 - 2014/05/02/ PY - 2013/10/24/received PY - 2014/04/14/revised PY - 2014/04/24/accepted PY - 2014/5/6/entrez PY - 2014/5/6/pubmed PY - 2015/3/10/medline KW - EEG KW - GABAb KW - Inhibition KW - N100 KW - TEPs KW - TMS SP - 225 EP - 32 JF - NeuroImage JO - Neuroimage VL - 98 N2 - The neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) have been mostly investigated by peripheral motor-evoked potentials (MEPs). New TMS-compatible EEG systems allow a direct investigation of the stimulation effects through the analysis of TMS-evoked potentials (TEPs). We investigated the effects of 1-Hz rTMS over the primary motor cortex (M1) of 15 healthy volunteers on TEP evoked by single pulse TMS over the same area. A second experiment in which rTMS was delivered over the primary visual cortex (V1) of 15 healthy volunteers was conducted to examine the spatial specificity of the effects. Single-pulse TMS evoked four main components: P30, N45, P60 and N100. M1-rTMS resulted in a significant decrease of MEP amplitude and in a significant increase of P60 and N100 amplitude. There was no effect after V1-rTMS. 1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials. Our results confirm the reliability of the TMS-evoked N100 as a marker of cortical inhibition and provide insight into the neuromodulatory effects of 1-Hz rTMS. The present finding could be of relevance for therapeutic and diagnostic purposes. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/24793831/Low_frequency_rTMS_inhibitory_effects_in_the_primary_motor_cortex:_Insights_from_TMS_evoked_potentials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(14)00345-0 DB - PRIME DP - Unbound Medicine ER -