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Oxidants and anti-oxidants status in acne vulgaris patients with varying severity.
Ann Clin Lab Sci. 2014 Spring; 44(2):202-7.AC

Abstract

Acne vulgaris is a common dermatological disorder with a multifactorial pathogenesis. Oxidative status has been implicated in the pathogenesis of several skin diseases, including acne. This study was aimed to investigate the levels of oxidative stress biomarkers in acne vulgaris patients with varying severities. The study involved 156 patients with acne and 46 healthy human controls. Based on clinical examination, patients were grouped into 3 subgroups as follows: mild, moderate, and severe acne. Oxidative stress was examined by measuring plasma levels of catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), and malondialdehyde (MDA). Plasma levels of MDA in acne patients were significantly higher as compared with that of the controls, whereas activities of the antioxidant enzymes SOD and CAT were lower. Moreover, TAC was also low in acne patients as compared with that of the controls. Higher MDA levels in the severe acne subgroup as compared with that of the mild and moderate subgroups were also observed. Furthermore, in the severe acne subgroup, a significant negative correlation was observed between MDA and CAT levels. The data suggests that oxidative stress plays a key role in acne progress and may be employed as a biomarker index to assess the disease's activity and to monitor its treatment.

Authors+Show Affiliations

Consultant Dermatologist, College Of Medicine, Qassim University, P.O. Box 5578 Unaizah51911, Saudi Arabia; fax: + 966 6 380 1228; hanisat@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24795060

Citation

Al-Shobaili, Hani A.. "Oxidants and Anti-oxidants Status in Acne Vulgaris Patients With Varying Severity." Annals of Clinical and Laboratory Science, vol. 44, no. 2, 2014, pp. 202-7.
Al-Shobaili HA. Oxidants and anti-oxidants status in acne vulgaris patients with varying severity. Ann Clin Lab Sci. 2014;44(2):202-7.
Al-Shobaili, H. A. (2014). Oxidants and anti-oxidants status in acne vulgaris patients with varying severity. Annals of Clinical and Laboratory Science, 44(2), 202-7.
Al-Shobaili HA. Oxidants and Anti-oxidants Status in Acne Vulgaris Patients With Varying Severity. Ann Clin Lab Sci. 2014;44(2):202-7. PubMed PMID: 24795060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidants and anti-oxidants status in acne vulgaris patients with varying severity. A1 - Al-Shobaili,Hani A, PY - 2014/5/6/entrez PY - 2014/5/6/pubmed PY - 2014/12/18/medline KW - Acne vulgaris KW - catalase KW - malondialdehyde KW - superoxide dismutase KW - total antioxidant capacity SP - 202 EP - 7 JF - Annals of clinical and laboratory science JO - Ann Clin Lab Sci VL - 44 IS - 2 N2 - Acne vulgaris is a common dermatological disorder with a multifactorial pathogenesis. Oxidative status has been implicated in the pathogenesis of several skin diseases, including acne. This study was aimed to investigate the levels of oxidative stress biomarkers in acne vulgaris patients with varying severities. The study involved 156 patients with acne and 46 healthy human controls. Based on clinical examination, patients were grouped into 3 subgroups as follows: mild, moderate, and severe acne. Oxidative stress was examined by measuring plasma levels of catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), and malondialdehyde (MDA). Plasma levels of MDA in acne patients were significantly higher as compared with that of the controls, whereas activities of the antioxidant enzymes SOD and CAT were lower. Moreover, TAC was also low in acne patients as compared with that of the controls. Higher MDA levels in the severe acne subgroup as compared with that of the mild and moderate subgroups were also observed. Furthermore, in the severe acne subgroup, a significant negative correlation was observed between MDA and CAT levels. The data suggests that oxidative stress plays a key role in acne progress and may be employed as a biomarker index to assess the disease's activity and to monitor its treatment. SN - 1550-8080 UR - https://www.unboundmedicine.com/medline/citation/24795060/Oxidants_and_anti_oxidants_status_in_acne_vulgaris_patients_with_varying_severity_ L2 - http://www.annclinlabsci.org/cgi/pmidlookup?view=long&pmid=24795060 DB - PRIME DP - Unbound Medicine ER -