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Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract.
Gastroenterology. 2014 Aug; 147(2):303-13.G

Abstract

Carbon monoxide (CO) and hydrogen sulfide (H2S) used to be thought of simply as lethal and (for H2S) smelly gaseous molecules; now they are known to have important signaling functions in the gastrointestinal tract. CO and H2S, which are produced in the gastrointestinal tract by different enzymes, regulate smooth muscle membrane potential and tone, transmit signals from enteric nerves, and can regulate the immune system. The pathways that produce nitric oxide, H2S, and CO interact; each can inhibit and potentiate the level and activity of the other. However, there are significant differences between these molecules, such as in half-lives; CO is more stable and therefore able to have effects distal to the site of production, whereas nitric oxide and H2S are short lived and act only close to sites of production. We review their signaling functions in the luminal gastrointestinal tract and discuss how their pathways interact. We also describe other physiological functions of CO and H2S and how they might be used as therapeutic agents.

Authors+Show Affiliations

Enteric NeuroScience Program, Division of Gastroenterology and Hepatology and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota. Electronic address: farrugia.gianrico@mayo.edu.Enteric NeuroScience Program, Division of Gastroenterology and Hepatology and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

24798417

Citation

Farrugia, Gianrico, and Joseph H. Szurszewski. "Carbon Monoxide, Hydrogen Sulfide, and Nitric Oxide as Signaling Molecules in the Gastrointestinal Tract." Gastroenterology, vol. 147, no. 2, 2014, pp. 303-13.
Farrugia G, Szurszewski JH. Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract. Gastroenterology. 2014;147(2):303-13.
Farrugia, G., & Szurszewski, J. H. (2014). Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract. Gastroenterology, 147(2), 303-13. https://doi.org/10.1053/j.gastro.2014.04.041
Farrugia G, Szurszewski JH. Carbon Monoxide, Hydrogen Sulfide, and Nitric Oxide as Signaling Molecules in the Gastrointestinal Tract. Gastroenterology. 2014;147(2):303-13. PubMed PMID: 24798417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract. AU - Farrugia,Gianrico, AU - Szurszewski,Joseph H, Y1 - 2014/05/02/ PY - 2014/02/10/received PY - 2014/04/16/revised PY - 2014/04/24/accepted PY - 2014/5/7/entrez PY - 2014/5/7/pubmed PY - 2014/9/12/medline KW - Gases KW - Gastrointestinal Motility KW - Neurotransmission KW - Signal Transduction KW - Smooth Muscle SP - 303 EP - 13 JF - Gastroenterology JO - Gastroenterology VL - 147 IS - 2 N2 - Carbon monoxide (CO) and hydrogen sulfide (H2S) used to be thought of simply as lethal and (for H2S) smelly gaseous molecules; now they are known to have important signaling functions in the gastrointestinal tract. CO and H2S, which are produced in the gastrointestinal tract by different enzymes, regulate smooth muscle membrane potential and tone, transmit signals from enteric nerves, and can regulate the immune system. The pathways that produce nitric oxide, H2S, and CO interact; each can inhibit and potentiate the level and activity of the other. However, there are significant differences between these molecules, such as in half-lives; CO is more stable and therefore able to have effects distal to the site of production, whereas nitric oxide and H2S are short lived and act only close to sites of production. We review their signaling functions in the luminal gastrointestinal tract and discuss how their pathways interact. We also describe other physiological functions of CO and H2S and how they might be used as therapeutic agents. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/24798417/Carbon_monoxide_hydrogen_sulfide_and_nitric_oxide_as_signaling_molecules_in_the_gastrointestinal_tract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(14)00597-6 DB - PRIME DP - Unbound Medicine ER -