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The response of newly born mice to odors of murine colostrum and milk: unconditionally attractive, conditionally discriminated.
Dev Psychobiol. 2014 Sep; 56(6):1365-76.DP

Abstract

It is a general rule that milk conveys chemosensory cues that are attractive to mammalian neonates. This study investigated whether compositional fluctuations in milk along lactation induce variations in newborn mouse pups' (Mus musculus, strain BALB/c) attraction to milk odor. Pups differing in suckling experience were exposed to the odor of milk sampled from females varying in lactational stage. Immediately after birth, suckling-inexperienced (P0) and suckling-experienced (P0suck) pups were assayed in a series of paired-choice tests contrasting murine milk [of lactation days 0, 3, 15 (abridged L0, L3, L15, respectively)] and a blank (water) to evaluate olfactory detection and attraction of milk odor. Preference tests further paired these milk two-by-two to assess their relative attraction. Results showed first that P0 and P0suck pups detect and positively orient to any milk odor. When L0 is presented against L15 milk, P0 pups orient for a similar duration towards these odor stimuli, whereas P0suck pups spend more time toward the odor of L0 than of L15 milk. Finally, P0suck pups orient similarly to odors of L0 milk collected before/after the first suckling episode (L0 and L0suck , respectively), but the odor of L0 milk was more attractive than that of L3 milk. Thus, mouse pups' positive orientation toward the odors of murine colostrum (assumed to correspond to L0/L0suck milk) and later-lactation milk appears unconditional of previous suckling experience, whereas their ability to discriminate or display preference between milk differing in lactation stage appears conditional on postnatal exposure effects.

Authors+Show Affiliations

Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Go슩t, Dijon, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24798460

Citation

Al Aïn, Syrina, et al. "The Response of Newly Born Mice to Odors of Murine Colostrum and Milk: Unconditionally Attractive, Conditionally Discriminated." Developmental Psychobiology, vol. 56, no. 6, 2014, pp. 1365-76.
Al Aïn S, Mingioni M, Patris B, et al. The response of newly born mice to odors of murine colostrum and milk: unconditionally attractive, conditionally discriminated. Dev Psychobiol. 2014;56(6):1365-76.
Al Aïn, S., Mingioni, M., Patris, B., & Schaal, B. (2014). The response of newly born mice to odors of murine colostrum and milk: unconditionally attractive, conditionally discriminated. Developmental Psychobiology, 56(6), 1365-76. https://doi.org/10.1002/dev.21220
Al Aïn S, et al. The Response of Newly Born Mice to Odors of Murine Colostrum and Milk: Unconditionally Attractive, Conditionally Discriminated. Dev Psychobiol. 2014;56(6):1365-76. PubMed PMID: 24798460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The response of newly born mice to odors of murine colostrum and milk: unconditionally attractive, conditionally discriminated. AU - Al Aïn,Syrina, AU - Mingioni,Mathieu, AU - Patris,Bruno, AU - Schaal,Benoist, Y1 - 2014/05/04/ PY - 2013/12/03/received PY - 2014/04/09/accepted PY - 2014/5/7/entrez PY - 2014/5/7/pubmed PY - 2015/4/11/medline KW - Laboratory mouse (Mus musculus) KW - colostrum KW - lactation KW - milk KW - newborn KW - olfaction KW - sucking SP - 1365 EP - 76 JF - Developmental psychobiology JO - Dev Psychobiol VL - 56 IS - 6 N2 - It is a general rule that milk conveys chemosensory cues that are attractive to mammalian neonates. This study investigated whether compositional fluctuations in milk along lactation induce variations in newborn mouse pups' (Mus musculus, strain BALB/c) attraction to milk odor. Pups differing in suckling experience were exposed to the odor of milk sampled from females varying in lactational stage. Immediately after birth, suckling-inexperienced (P0) and suckling-experienced (P0suck) pups were assayed in a series of paired-choice tests contrasting murine milk [of lactation days 0, 3, 15 (abridged L0, L3, L15, respectively)] and a blank (water) to evaluate olfactory detection and attraction of milk odor. Preference tests further paired these milk two-by-two to assess their relative attraction. Results showed first that P0 and P0suck pups detect and positively orient to any milk odor. When L0 is presented against L15 milk, P0 pups orient for a similar duration towards these odor stimuli, whereas P0suck pups spend more time toward the odor of L0 than of L15 milk. Finally, P0suck pups orient similarly to odors of L0 milk collected before/after the first suckling episode (L0 and L0suck , respectively), but the odor of L0 milk was more attractive than that of L3 milk. Thus, mouse pups' positive orientation toward the odors of murine colostrum (assumed to correspond to L0/L0suck milk) and later-lactation milk appears unconditional of previous suckling experience, whereas their ability to discriminate or display preference between milk differing in lactation stage appears conditional on postnatal exposure effects. SN - 1098-2302 UR - https://www.unboundmedicine.com/medline/citation/24798460/The_response_of_newly_born_mice_to_odors_of_murine_colostrum_and_milk:_unconditionally_attractive_conditionally_discriminated_ L2 - https://doi.org/10.1002/dev.21220 DB - PRIME DP - Unbound Medicine ER -