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Studies into gastrinomas and combined carcinomatous carcinoid tumors. Optical light- and electron microscopy and immunohistochemistry.
Zentralbl Allg Pathol. 1989; 135(7):657-65.ZA

Abstract

The clinical, microscopic, immunohistochemical and ultrastructural features of 7 gastrinomas and 1 combined carcinoma-carcinoid tumor were evaluated. The tumors were located in the pancreas or duodenal wall in 6 cases, and on extragastro-enteropancreatic sites in 2 (liver or peripancreatic lymph node). All patients had the Zollinger-Ellison syndrome, 3 of them with additional bleeding and 1 with diarrhea. One patient with gastrinoma had additional tumors characteristic of the MEN-I syndrome. Immunohistochemistry showed gastrin and neuron-specific enolase-positivity in all of the tumors. Somatostatin was found in 4 cases, and single cell glucagon, pancreatic polypeptide. S-100 protein, keratin as well as carcino-embryonic antigen positivity in another few. Additional hormone production did not appear to be connected with biological behaviour of the tumors or with the clinical symptoms.

Authors+Show Affiliations

Department of Pathology, Albert Szent-Györgyi Medical University, Szeged, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2480034

Citation

Lászik, Z, et al. "Studies Into Gastrinomas and Combined Carcinomatous Carcinoid Tumors. Optical Light- and Electron Microscopy and Immunohistochemistry." Zentralblatt Fur Allgemeine Pathologie U. Pathologische Anatomie, vol. 135, no. 7, 1989, pp. 657-65.
Lászik Z, Krenács T, Baltás B, et al. Studies into gastrinomas and combined carcinomatous carcinoid tumors. Optical light- and electron microscopy and immunohistochemistry. Zentralbl Allg Pathol. 1989;135(7):657-65.
Lászik, Z., Krenács, T., Baltás, B., Pap, A., & Karácsony, S. (1989). Studies into gastrinomas and combined carcinomatous carcinoid tumors. Optical light- and electron microscopy and immunohistochemistry. Zentralblatt Fur Allgemeine Pathologie U. Pathologische Anatomie, 135(7), 657-65.
Lászik Z, et al. Studies Into Gastrinomas and Combined Carcinomatous Carcinoid Tumors. Optical Light- and Electron Microscopy and Immunohistochemistry. Zentralbl Allg Pathol. 1989;135(7):657-65. PubMed PMID: 2480034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies into gastrinomas and combined carcinomatous carcinoid tumors. Optical light- and electron microscopy and immunohistochemistry. AU - Lászik,Z, AU - Krenács,T, AU - Baltás,B, AU - Pap,A, AU - Karácsony,S, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 657 EP - 65 JF - Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie JO - Zentralbl Allg Pathol VL - 135 IS - 7 N2 - The clinical, microscopic, immunohistochemical and ultrastructural features of 7 gastrinomas and 1 combined carcinoma-carcinoid tumor were evaluated. The tumors were located in the pancreas or duodenal wall in 6 cases, and on extragastro-enteropancreatic sites in 2 (liver or peripancreatic lymph node). All patients had the Zollinger-Ellison syndrome, 3 of them with additional bleeding and 1 with diarrhea. One patient with gastrinoma had additional tumors characteristic of the MEN-I syndrome. Immunohistochemistry showed gastrin and neuron-specific enolase-positivity in all of the tumors. Somatostatin was found in 4 cases, and single cell glucagon, pancreatic polypeptide. S-100 protein, keratin as well as carcino-embryonic antigen positivity in another few. Additional hormone production did not appear to be connected with biological behaviour of the tumors or with the clinical symptoms. SN - 0044-4030 UR - https://www.unboundmedicine.com/medline/citation/2480034/Studies_into_gastrinomas_and_combined_carcinomatous_carcinoid_tumors__Optical_light__and_electron_microscopy_and_immunohistochemistry_ L2 - https://medlineplus.gov/intestinalcancer.html DB - PRIME DP - Unbound Medicine ER -