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Relationship of thyroid-stimulating hormone with metabolic syndrome in a sample of euthyroid Pakistani population.
J Ayub Med Coll Abbottabad. 2011 Apr-Jun; 23(2):63-8.JA

Abstract

BACKGROUND

Metabolic Syndrome is a group of factors that predispose to cardiovascular diseases. The prevalence of metabolic syndrome is rising rapidly. Recently, a few studies have suggested that lower thyroid function in the reference range may be associated with metabolic syndrome, but the issue remains unsettled. We aimed to elucidate the relationship between thyroid function and components of metabolic syndrome in a sample of euthyroid Pakistani population.

METHODS

This analytical, cross-sectional study was conducted at the Department of Physiology, University of Health Sciences, Lahore, Pakistan, and extended over a period of 12 months. It included 100 subjects with metabolic syndrome in the study group and thirty subjects without metabolic syndrome in the control group with age ranging 45-55 years. Both groups had normal thyroid function. After a detailed history and clinical examination, fasting blood was analysed for glucose, triglycerides, high density lipoprotein-cholesterol along with thyroid-stimulating hormone (TSH) and free thyroxine.

RESULTS

Serum TSH was significantly higher in study group than in control group (p = 0.040). Serum free thyroxine values of study group were slightly but not significantly lower than those of control group. Serum TSH correlated significantly and positively with serum triglycerides in all subjects and with waist circumference and diastolic blood pressure in men. Serum TSH showed a positive and linear relationship with the number of components of metabolic syndrome (p = 0.016) in all subjects.

CONCLUSION

High-normal TSH is associated with metabolic syndrome and its components. There may be increased risk of cardiovascular diseases with high-normal TSH levels.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24800345

Citation

Saleem, Muhammad Shahzad, et al. "Relationship of Thyroid-stimulating Hormone With Metabolic Syndrome in a Sample of Euthyroid Pakistani Population." Journal of Ayub Medical College, Abbottabad : JAMC, vol. 23, no. 2, 2011, pp. 63-8.
Saleem MS, Shirwany TA, Khan KA. Relationship of thyroid-stimulating hormone with metabolic syndrome in a sample of euthyroid Pakistani population. J Ayub Med Coll Abbottabad. 2011;23(2):63-8.
Saleem, M. S., Shirwany, T. A., & Khan, K. A. (2011). Relationship of thyroid-stimulating hormone with metabolic syndrome in a sample of euthyroid Pakistani population. Journal of Ayub Medical College, Abbottabad : JAMC, 23(2), 63-8.
Saleem MS, Shirwany TA, Khan KA. Relationship of Thyroid-stimulating Hormone With Metabolic Syndrome in a Sample of Euthyroid Pakistani Population. J Ayub Med Coll Abbottabad. 2011 Apr-Jun;23(2):63-8. PubMed PMID: 24800345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of thyroid-stimulating hormone with metabolic syndrome in a sample of euthyroid Pakistani population. AU - Saleem,Muhammad Shahzad, AU - Shirwany,Tanvir Ali Khan, AU - Khan,Khurshid Ahmad, PY - 2014/5/8/entrez PY - 2011/4/1/pubmed PY - 2014/6/27/medline SP - 63 EP - 8 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 23 IS - 2 N2 - BACKGROUND: Metabolic Syndrome is a group of factors that predispose to cardiovascular diseases. The prevalence of metabolic syndrome is rising rapidly. Recently, a few studies have suggested that lower thyroid function in the reference range may be associated with metabolic syndrome, but the issue remains unsettled. We aimed to elucidate the relationship between thyroid function and components of metabolic syndrome in a sample of euthyroid Pakistani population. METHODS: This analytical, cross-sectional study was conducted at the Department of Physiology, University of Health Sciences, Lahore, Pakistan, and extended over a period of 12 months. It included 100 subjects with metabolic syndrome in the study group and thirty subjects without metabolic syndrome in the control group with age ranging 45-55 years. Both groups had normal thyroid function. After a detailed history and clinical examination, fasting blood was analysed for glucose, triglycerides, high density lipoprotein-cholesterol along with thyroid-stimulating hormone (TSH) and free thyroxine. RESULTS: Serum TSH was significantly higher in study group than in control group (p = 0.040). Serum free thyroxine values of study group were slightly but not significantly lower than those of control group. Serum TSH correlated significantly and positively with serum triglycerides in all subjects and with waist circumference and diastolic blood pressure in men. Serum TSH showed a positive and linear relationship with the number of components of metabolic syndrome (p = 0.016) in all subjects. CONCLUSION: High-normal TSH is associated with metabolic syndrome and its components. There may be increased risk of cardiovascular diseases with high-normal TSH levels. SN - 1025-9589 UR - https://www.unboundmedicine.com/medline/citation/24800345/Relationship_of_thyroid_stimulating_hormone_with_metabolic_syndrome_in_a_sample_of_euthyroid_Pakistani_population_ L2 - https://medlineplus.gov/metabolicsyndrome.html DB - PRIME DP - Unbound Medicine ER -