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High infection rate of bank voles (Myodes glareolus) with Puumala virus is associated with a winter outbreak of haemorrhagic fever with renal syndrome in Croatia.
Epidemiol Infect. 2014 Sep; 142(9):1945-51.EI

Abstract

An outbreak of haemorrhagic fever with renal syndrome (HFRS) started on Medvednica mountain near Zagreb in January 2012. In order to detect the aetiological agent of the disease in small rodents and to make the link with the human outbreak, rodents were trapped at four different altitudes. Using nested RT-PCR, Puumala virus (PUUV) RNA was detected in 41/53 (77·4%) bank voles (Myodes glareolus) and Dobrava virus (DOBV) RNA was found in 6/61 (9·8%) yellow-necked mice (Apodemus flavicollis). Sequence analysis of a 341-nucleotide region of the PUUV S segment, obtained from all infected bank voles and five HFRS patients, showed 98·8-100% sequence similarity, indicating that the patients were probably exposed to PUUV on Medvednica mountain. A very large bank-vole population combined with an extremely high infection rate of PUUV was responsible for this unusual winter outbreak of HFRS in Croatia.

Authors+Show Affiliations

University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.Faculty of Forestry,University of Zagreb,Zagreb,Croatia.Faculty of Forestry,University of Zagreb,Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.Faculty of Veterinary Medicine,University of Zagreb,Zagreb,Croatia.Faculty of Veterinary Medicine,University of Zagreb,Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic',Zagreb,Croatia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24800636

Citation

Tadin, A, et al. "High Infection Rate of Bank Voles (Myodes Glareolus) With Puumala Virus Is Associated With a Winter Outbreak of Haemorrhagic Fever With Renal Syndrome in Croatia." Epidemiology and Infection, vol. 142, no. 9, 2014, pp. 1945-51.
Tadin A, Bjedov L, Margaletic J, et al. High infection rate of bank voles (Myodes glareolus) with Puumala virus is associated with a winter outbreak of haemorrhagic fever with renal syndrome in Croatia. Epidemiol Infect. 2014;142(9):1945-51.
Tadin, A., Bjedov, L., Margaletic, J., Zibrat, B., Krajinovic, L. C., Svoboda, P., Kurolt, I. C., Majetic, Z. S., Turk, N., Rode, O. D., Civljak, R., Kuzman, I., & Markotic, A. (2014). High infection rate of bank voles (Myodes glareolus) with Puumala virus is associated with a winter outbreak of haemorrhagic fever with renal syndrome in Croatia. Epidemiology and Infection, 142(9), 1945-51. https://doi.org/10.1017/S095026881300321X
Tadin A, et al. High Infection Rate of Bank Voles (Myodes Glareolus) With Puumala Virus Is Associated With a Winter Outbreak of Haemorrhagic Fever With Renal Syndrome in Croatia. Epidemiol Infect. 2014;142(9):1945-51. PubMed PMID: 24800636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High infection rate of bank voles (Myodes glareolus) with Puumala virus is associated with a winter outbreak of haemorrhagic fever with renal syndrome in Croatia. AU - Tadin,A, AU - Bjedov,L, AU - Margaletic,J, AU - Zibrat,B, AU - Krajinovic,L Cvetko, AU - Svoboda,P, AU - Kurolt,I C, AU - Majetic,Z Stritof, AU - Turk,N, AU - Rode,O Dakovic, AU - Civljak,R, AU - Kuzman,I, AU - Markotic,A, Y1 - 2014/01/02/ PY - 2014/5/8/entrez PY - 2014/5/8/pubmed PY - 2014/9/3/medline SP - 1945 EP - 51 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 142 IS - 9 N2 - An outbreak of haemorrhagic fever with renal syndrome (HFRS) started on Medvednica mountain near Zagreb in January 2012. In order to detect the aetiological agent of the disease in small rodents and to make the link with the human outbreak, rodents were trapped at four different altitudes. Using nested RT-PCR, Puumala virus (PUUV) RNA was detected in 41/53 (77·4%) bank voles (Myodes glareolus) and Dobrava virus (DOBV) RNA was found in 6/61 (9·8%) yellow-necked mice (Apodemus flavicollis). Sequence analysis of a 341-nucleotide region of the PUUV S segment, obtained from all infected bank voles and five HFRS patients, showed 98·8-100% sequence similarity, indicating that the patients were probably exposed to PUUV on Medvednica mountain. A very large bank-vole population combined with an extremely high infection rate of PUUV was responsible for this unusual winter outbreak of HFRS in Croatia. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/24800636/High_infection_rate_of_bank_voles__Myodes_glareolus__with_Puumala_virus_is_associated_with_a_winter_outbreak_of_haemorrhagic_fever_with_renal_syndrome_in_Croatia_ L2 - https://www.cambridge.org/core/product/identifier/S095026881300321X/type/journal_article DB - PRIME DP - Unbound Medicine ER -