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Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.
Neurosci Res. 2014 Jul; 84:60-3.NR

Abstract

Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10μg/1μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.

Authors+Show Affiliations

Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.Laboratorio de Neurobiología, Departamento de Neurociencias, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico. Electronic address: eric.murillo@anahuac.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24800644

Citation

Mijangos-Moreno, Stephanie, et al. "Intrahypothalamic Injection of Cannabidiol Increases the Extracellular Levels of Adenosine in Nucleus Accumbens in Rats." Neuroscience Research, vol. 84, 2014, pp. 60-3.
Mijangos-Moreno S, Poot-Aké A, Arankowsky-Sandoval G, et al. Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. Neurosci Res. 2014;84:60-3.
Mijangos-Moreno, S., Poot-Aké, A., Arankowsky-Sandoval, G., & Murillo-Rodríguez, E. (2014). Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. Neuroscience Research, 84, 60-3. https://doi.org/10.1016/j.neures.2014.04.006
Mijangos-Moreno S, et al. Intrahypothalamic Injection of Cannabidiol Increases the Extracellular Levels of Adenosine in Nucleus Accumbens in Rats. Neurosci Res. 2014;84:60-3. PubMed PMID: 24800644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. AU - Mijangos-Moreno,Stephanie, AU - Poot-Aké,Alwin, AU - Arankowsky-Sandoval,Gloria, AU - Murillo-Rodríguez,Eric, Y1 - 2014/05/04/ PY - 2014/02/20/received PY - 2014/04/01/revised PY - 2014/04/22/accepted PY - 2014/5/8/entrez PY - 2014/5/8/pubmed PY - 2015/6/9/medline KW - Adenosine KW - HPLC KW - Hypothalamus KW - Microdialysis KW - Wakefulness SP - 60 EP - 3 JF - Neuroscience research JO - Neurosci Res VL - 84 N2 - Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10μg/1μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/24800644/Intrahypothalamic_injection_of_cannabidiol_increases_the_extracellular_levels_of_adenosine_in_nucleus_accumbens_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(14)00071-6 DB - PRIME DP - Unbound Medicine ER -