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Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.
Neurosci Res. 2014 Jul; 84:60-3.NR

Abstract

Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10μg/1μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.

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Authors+Show Affiliations

Mijangos-Moreno S
Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.
Poot-Aké A
Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.
Arankowsky-Sandoval G
Laboratorio de Neurobiología, Departamento de Neurociencias, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
Murillo-Rodríguez E
Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico. Electronic address: eric.murillo@anahuac.mx.

MeSH

AdenosineAnimalsCannabidiolExtracellular SpaceHypothalamusMaleMicroinjectionsNucleus AccumbensRatsRats, WistarTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24800644

Citation

Mijangos-Moreno, Stephanie, et al. "Intrahypothalamic Injection of Cannabidiol Increases the Extracellular Levels of Adenosine in Nucleus Accumbens in Rats." Neuroscience Research, vol. 84, 2014, pp. 60-3.
Mijangos-Moreno S, Poot-Aké A, Arankowsky-Sandoval G, et al. Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. Neurosci Res. 2014;84:60-3.
Mijangos-Moreno, S., Poot-Aké, A., Arankowsky-Sandoval, G., & Murillo-Rodríguez, E. (2014). Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. Neuroscience Research, 84, 60-3. https://doi.org/10.1016/j.neures.2014.04.006
Mijangos-Moreno S, et al. Intrahypothalamic Injection of Cannabidiol Increases the Extracellular Levels of Adenosine in Nucleus Accumbens in Rats. Neurosci Res. 2014;84:60-3. PubMed PMID: 24800644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. AU - Mijangos-Moreno,Stephanie, AU - Poot-Aké,Alwin, AU - Arankowsky-Sandoval,Gloria, AU - Murillo-Rodríguez,Eric, Y1 - 2014/05/04/ PY - 2014/02/20/received PY - 2014/04/01/revised PY - 2014/04/22/accepted PY - 2014/5/8/entrez PY - 2014/5/8/pubmed PY - 2015/6/9/medline KW - Adenosine KW - HPLC KW - Hypothalamus KW - Microdialysis KW - Wakefulness SP - 60 EP - 3 JF - Neuroscience research JO - Neurosci Res VL - 84 N2 - Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10μg/1μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/24800644/Intrahypothalamic_injection_of_cannabidiol_increases_the_extracellular_levels_of_adenosine_in_nucleus_accumbens_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(14)00071-6 DB - PRIME DP - Unbound Medicine ER -