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Omega-3 fatty acids and asthma in children.
Allergy Asthma Proc. 2014 May-Jun; 35(3):233-40.AA

Abstract

The purpose of this study was to summarize and analyze the results of studies supporting the use of omega-3 fatty acids for their therapeutic and preventive value in childhood asthma in light of recent genetic evidence strongly suggesting a pathogenetic role in asthma and to discuss the implications of these findings for future research. Although a considerable number of observational studies have been conducted in children showing a beneficial effect of omega-3 dietary intake in asthma, a fully well-designed, rigorously conducted investigational study is still lacking. Additionally, the few interventional trials with omega-3 supplementation conducted in asthmatic children have often yielded conflicting results. The genetic polymorphism and the gene-nutritional interactions that accompany asthma can be the missing factors and may explain the inconsistent results found in these interventional trials. Therefore, the analyses of key genes variants should be included in future studies to thoroughly investigate the effects of long-chain polyunsaturated fatty acid on asthma. Although a definitive conclusion can not be made supporting a beneficial effect of dietary modification or supplementation with omega-3 for the prevention or modification of asthmatic disease in children, there is sufficient evidence to support this possibility. There is, therefore, a clear need for future research to investigate the feasibility of this dietetic approach to reduce the likely development of asthma and/or the successful treatment of asthmatic disease. From a public health perspective, if a dietetic approach is successfully documented, even if only in a cohort of susceptible individuals, it would offer a far better management tool than currently available, better tolerated, and, in the long run, more cost-effective.

Authors+Show Affiliations

Department of Pediatrics San Paolo Hospital, University of Milan, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24801466

Citation

D'Auria, Enza, et al. "Omega-3 Fatty Acids and Asthma in Children." Allergy and Asthma Proceedings, vol. 35, no. 3, 2014, pp. 233-40.
D'Auria E, Miraglia Del Giudice M, Barberi S, et al. Omega-3 fatty acids and asthma in children. Allergy Asthma Proc. 2014;35(3):233-40.
D'Auria, E., Miraglia Del Giudice, M., Barberi, S., Mandelli, M., Verduci, E., Leonardi, S., Riva, E., & Giovannini, M. (2014). Omega-3 fatty acids and asthma in children. Allergy and Asthma Proceedings, 35(3), 233-40. https://doi.org/10.2500/aap.2014.35.3736
D'Auria E, et al. Omega-3 Fatty Acids and Asthma in Children. Allergy Asthma Proc. 2014 May-Jun;35(3):233-40. PubMed PMID: 24801466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids and asthma in children. AU - D'Auria,Enza, AU - Miraglia Del Giudice,Michele, AU - Barberi,Salvatore, AU - Mandelli,Marzia, AU - Verduci,Elvira, AU - Leonardi,Salvatore, AU - Riva,Enrica, AU - Giovannini,Marcello, PY - 2014/5/8/entrez PY - 2014/5/8/pubmed PY - 2014/12/30/medline SP - 233 EP - 40 JF - Allergy and asthma proceedings JO - Allergy Asthma Proc VL - 35 IS - 3 N2 - The purpose of this study was to summarize and analyze the results of studies supporting the use of omega-3 fatty acids for their therapeutic and preventive value in childhood asthma in light of recent genetic evidence strongly suggesting a pathogenetic role in asthma and to discuss the implications of these findings for future research. Although a considerable number of observational studies have been conducted in children showing a beneficial effect of omega-3 dietary intake in asthma, a fully well-designed, rigorously conducted investigational study is still lacking. Additionally, the few interventional trials with omega-3 supplementation conducted in asthmatic children have often yielded conflicting results. The genetic polymorphism and the gene-nutritional interactions that accompany asthma can be the missing factors and may explain the inconsistent results found in these interventional trials. Therefore, the analyses of key genes variants should be included in future studies to thoroughly investigate the effects of long-chain polyunsaturated fatty acid on asthma. Although a definitive conclusion can not be made supporting a beneficial effect of dietary modification or supplementation with omega-3 for the prevention or modification of asthmatic disease in children, there is sufficient evidence to support this possibility. There is, therefore, a clear need for future research to investigate the feasibility of this dietetic approach to reduce the likely development of asthma and/or the successful treatment of asthmatic disease. From a public health perspective, if a dietetic approach is successfully documented, even if only in a cohort of susceptible individuals, it would offer a far better management tool than currently available, better tolerated, and, in the long run, more cost-effective. SN - 1539-6304 UR - https://www.unboundmedicine.com/medline/citation/24801466/Omega_3_fatty_acids_and_asthma_in_children_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1088-5412&volume=35&issue=3&spage=233&aulast=D'Auria DB - PRIME DP - Unbound Medicine ER -