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Elevated carboxyhemoglobin: sources of carbon monoxide exposure.
Arch Bronconeumol. 2014 Nov; 50(11):465-8.AB

Abstract

INTRODUCTION

Inhalation of carbon monoxide (CO) can result in poisoning, with symptoms ranging from mild and nonspecific to severe, or even death. CO poisoning is often underdiagnosed because exposure to low concentrations goes unnoticed, and threshold values for normal carboxyhemoglobin vary according to different authors. The aim of our study was to analyze carboxyhemoglobin (COHb) levels in an unselected population and detect sources of CO exposure

METHODS

In a cross-sectional descriptive study, we analyzed consecutive arterial blood gas levels processed in our laboratory. We selected those with COHb≥2.5% in nonsmokers and ≥5% in smokers. In these cases a structured telephone interview was conducted.

RESULTS

Elevated levels of COHb were found in 64 (20%) of 306 initial determinations. Of these, data from 51 subjects aged 65±12 years, 31 (60%) of which were men, were obtained. Mean COHb was 4.0%. Forty patients (78%) were non-smokers with mean COHb of 3.2%, and 11 were smokers with COHb of 6.7%. In 45 patients (88.2%) we detected exposure to at least one source of ambient CO other than cigarette smoke.

CONCLUSIONS

A significant proportion of individuals from an unselected sample had elevated levels of COHb. The main sources of CO exposure were probably the home, so this possibility should be explored. The population should be warned about the risks and encouraged to take preventive measures.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Buchelli Ramirez H
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Fernández Alvarez R
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España. Electronic address: enelllano@gmail.com.
Rubinos Cuadrado G
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Martinez Gonzalez C
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Rodriguez Jerez F
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Casan Clara P
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

MeSH

AgedAir PollutantsAir Pollution, IndoorCarbon MonoxideCarboxyhemoglobinCookingCross-Sectional StudiesEnvironmental ExposureFemaleHousingHumansMaleMiddle AgedSmokingSpainSurveys and QuestionnairesVehicle Emissions

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

24809679

Citation

Buchelli Ramirez, Herminia, et al. "Elevated Carboxyhemoglobin: Sources of Carbon Monoxide Exposure." Archivos De Bronconeumologia, vol. 50, no. 11, 2014, pp. 465-8.
Buchelli Ramirez H, Fernández Alvarez R, Rubinos Cuadrado G, et al. Elevated carboxyhemoglobin: sources of carbon monoxide exposure. Arch Bronconeumol. 2014;50(11):465-8.
Buchelli Ramirez, H., Fernández Alvarez, R., Rubinos Cuadrado, G., Martinez Gonzalez, C., Rodriguez Jerez, F., & Casan Clara, P. (2014). Elevated carboxyhemoglobin: sources of carbon monoxide exposure. Archivos De Bronconeumologia, 50(11), 465-8. https://doi.org/10.1016/j.arbres.2014.03.005
Buchelli Ramirez H, et al. Elevated Carboxyhemoglobin: Sources of Carbon Monoxide Exposure. Arch Bronconeumol. 2014;50(11):465-8. PubMed PMID: 24809679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated carboxyhemoglobin: sources of carbon monoxide exposure. AU - Buchelli Ramirez,Herminia, AU - Fernández Alvarez,Ramón, AU - Rubinos Cuadrado,Gemma, AU - Martinez Gonzalez,Cristina, AU - Rodriguez Jerez,Francisco, AU - Casan Clara,Pere, Y1 - 2014/05/06/ PY - 2013/12/07/received PY - 2014/02/14/revised PY - 2014/03/10/accepted PY - 2014/5/10/entrez PY - 2014/5/9/pubmed PY - 2015/8/1/medline KW - Blood carbon monoxide levels KW - Carbon monoxide poisoning KW - Environmental carbon monoxide sources KW - Fuentes de exposición a monóxido de carbono KW - Intoxicación por monóxido de carbono KW - Niveles de monóxido de carbono en sangre SP - 465 EP - 8 JF - Archivos de bronconeumologia JO - Arch Bronconeumol VL - 50 IS - 11 N2 - INTRODUCTION: Inhalation of carbon monoxide (CO) can result in poisoning, with symptoms ranging from mild and nonspecific to severe, or even death. CO poisoning is often underdiagnosed because exposure to low concentrations goes unnoticed, and threshold values for normal carboxyhemoglobin vary according to different authors. The aim of our study was to analyze carboxyhemoglobin (COHb) levels in an unselected population and detect sources of CO exposure METHODS: In a cross-sectional descriptive study, we analyzed consecutive arterial blood gas levels processed in our laboratory. We selected those with COHb≥2.5% in nonsmokers and ≥5% in smokers. In these cases a structured telephone interview was conducted. RESULTS: Elevated levels of COHb were found in 64 (20%) of 306 initial determinations. Of these, data from 51 subjects aged 65±12 years, 31 (60%) of which were men, were obtained. Mean COHb was 4.0%. Forty patients (78%) were non-smokers with mean COHb of 3.2%, and 11 were smokers with COHb of 6.7%. In 45 patients (88.2%) we detected exposure to at least one source of ambient CO other than cigarette smoke. CONCLUSIONS: A significant proportion of individuals from an unselected sample had elevated levels of COHb. The main sources of CO exposure were probably the home, so this possibility should be explored. The population should be warned about the risks and encouraged to take preventive measures. SN - 1579-2129 UR - https://www.unboundmedicine.com/medline/citation/24809679/Elevated_carboxyhemoglobin:_sources_of_carbon_monoxide_exposure_ DB - PRIME DP - Unbound Medicine ER -