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Body mass index and weight change in men with prostate cancer: progression and mortality.

Abstract

PURPOSE

Body mass index (BMI) is a modifiable lifestyle factor that has been associated with an increased risk of fatal prostate cancer and biochemical recurrence. The main purpose of the present study was to investigate the association between the exposure BMI at the time of a prostate cancer diagnosis and weight change after diagnosis, and the outcomes of prostate cancer progression and mortality in a large cohort study.

METHODS

Data from 4,376 men diagnosed with clinically localized prostate cancer between 1997 and 2002 were analyzed. BMI and weight change were self-reported in 2007. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were estimated in complete-case analysis (n = 3,214) using Cox proportional hazards models.

RESULTS

Progression was experienced among 639 (14.6 %) of the study participants, and in total, 450 (10.3 %) deaths of any cause and 134 (3.1 %) prostate cancer-specific deaths were recorded during follow-up. Obese men had a 47 % increased rate of overall mortality compared to normal weight men (HR 1.47, 95 % CI 1.03-2.10). No statistically significant associations were found for BMI and prostate cancer progression or prostate cancer-specific mortality. A weight loss >5 % after diagnosis almost doubled the rate of overall mortality compared to maintaining a stable weight (HR 1.94, 95 % CI 1.41-2.66), while a weight gain >5 % was associated with an almost doubled increased rate of prostate cancer-specific mortality (HR 1.93, 95 % CI 1.18-3.16).

CONCLUSIONS

Being obese was associated with an increased rate of overall mortality, and gaining weight after a prostate cancer diagnosis was associated with an increased rate of prostate cancer-specific mortality.

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  • Authors+Show Affiliations

    ,

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 77, Stockholm, Sweden, stephanie.bonn@ki.se.

    , , , , , ,

    Source

    Cancer causes & control : CCC 25:8 2014 Aug pg 933-43

    MeSH

    Aged
    Body Mass Index
    Disease Progression
    Humans
    Life Style
    Male
    Middle Aged
    Obesity
    Proportional Hazards Models
    Prostatic Neoplasms
    Sweden
    Weight Gain
    Weight Loss

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24810654

    Citation

    Bonn, Stephanie E., et al. "Body Mass Index and Weight Change in Men With Prostate Cancer: Progression and Mortality." Cancer Causes & Control : CCC, vol. 25, no. 8, 2014, pp. 933-43.
    Bonn SE, Wiklund F, Sjölander A, et al. Body mass index and weight change in men with prostate cancer: progression and mortality. Cancer Causes Control. 2014;25(8):933-43.
    Bonn, S. E., Wiklund, F., Sjölander, A., Szulkin, R., Stattin, P., Holmberg, E., ... Bälter, K. (2014). Body mass index and weight change in men with prostate cancer: progression and mortality. Cancer Causes & Control : CCC, 25(8), pp. 933-43. doi:10.1007/s10552-014-0393-3.
    Bonn SE, et al. Body Mass Index and Weight Change in Men With Prostate Cancer: Progression and Mortality. Cancer Causes Control. 2014;25(8):933-43. PubMed PMID: 24810654.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body mass index and weight change in men with prostate cancer: progression and mortality. AU - Bonn,Stephanie E, AU - Wiklund,Fredrik, AU - Sjölander,Arvid, AU - Szulkin,Robert, AU - Stattin,Pär, AU - Holmberg,Erik, AU - Grönberg,Henrik, AU - Bälter,Katarina, Y1 - 2014/05/09/ PY - 2013/10/18/received PY - 2014/04/28/accepted PY - 2014/5/10/entrez PY - 2014/5/9/pubmed PY - 2015/3/11/medline SP - 933 EP - 43 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 25 IS - 8 N2 - PURPOSE: Body mass index (BMI) is a modifiable lifestyle factor that has been associated with an increased risk of fatal prostate cancer and biochemical recurrence. The main purpose of the present study was to investigate the association between the exposure BMI at the time of a prostate cancer diagnosis and weight change after diagnosis, and the outcomes of prostate cancer progression and mortality in a large cohort study. METHODS: Data from 4,376 men diagnosed with clinically localized prostate cancer between 1997 and 2002 were analyzed. BMI and weight change were self-reported in 2007. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were estimated in complete-case analysis (n = 3,214) using Cox proportional hazards models. RESULTS: Progression was experienced among 639 (14.6 %) of the study participants, and in total, 450 (10.3 %) deaths of any cause and 134 (3.1 %) prostate cancer-specific deaths were recorded during follow-up. Obese men had a 47 % increased rate of overall mortality compared to normal weight men (HR 1.47, 95 % CI 1.03-2.10). No statistically significant associations were found for BMI and prostate cancer progression or prostate cancer-specific mortality. A weight loss >5 % after diagnosis almost doubled the rate of overall mortality compared to maintaining a stable weight (HR 1.94, 95 % CI 1.41-2.66), while a weight gain >5 % was associated with an almost doubled increased rate of prostate cancer-specific mortality (HR 1.93, 95 % CI 1.18-3.16). CONCLUSIONS: Being obese was associated with an increased rate of overall mortality, and gaining weight after a prostate cancer diagnosis was associated with an increased rate of prostate cancer-specific mortality. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/24810654/full_citation L2 - https://doi.org/10.1007/s10552-014-0393-3 DB - PRIME DP - Unbound Medicine ER -