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Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice.
Neurosci Lett. 2014 Jun 24; 573:58-63.NL

Abstract

Xanthoceraside, a triterpenoid saponin, has been shown to reverse cognitive deficits in several Alzheimer's disease (AD) animal models. However, the effects of xanthoceraside on the Aβ deposition pathology and the APP processing in AD are unclear. Here, we show that xanthoceraside at doses of 0.08 and 0.32 mg/kg/d for 6 months significantly improved learning and memory impairment in APP transgenic mice assessed by the Y maze and novel object recognition tests. Immunohistochemical analyses revealed that xanthoceraside strongly attenuated β-amyloid deposition in the brains of APP transgenic mice. Western blotting revealed that xanthoceraside decreased tau phosphorylation protein levels at Ser396 and Ser404 in the hippocampus; xanthoceraside also decreased APP protein levels and GSK-3β phosphorylation. These results suggest that xanthoceraside could be a promising novel candidate for the therapy of AD.

Authors+Show Affiliations

Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Department of Pharmacology, Shenyang Medical Colleges, Shenyang 110034, PR China.Shenyang Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China.Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: libozou@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24810883

Citation

Jin, Ge, et al. "Xanthoceraside Rescues Learning and Memory Deficits Through Attenuating Beta-amyloid Deposition and Tau Hyperphosphorylation in APP Mice." Neuroscience Letters, vol. 573, 2014, pp. 58-63.
Jin G, Wang LH, Ji XF, et al. Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice. Neurosci Lett. 2014;573:58-63.
Jin, G., Wang, L. H., Ji, X. F., Chi, T. Y., Qi, Y., Jiao, Q., Xu, Q., Zhou, X. Y., Zhang, R., & Zou, L. B. (2014). Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice. Neuroscience Letters, 573, 58-63. https://doi.org/10.1016/j.neulet.2014.04.032
Jin G, et al. Xanthoceraside Rescues Learning and Memory Deficits Through Attenuating Beta-amyloid Deposition and Tau Hyperphosphorylation in APP Mice. Neurosci Lett. 2014 Jun 24;573:58-63. PubMed PMID: 24810883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice. AU - Jin,Ge, AU - Wang,Li-Hua, AU - Ji,Xue-Fei, AU - Chi,Tian-Yan, AU - Qi,Yue, AU - Jiao,Qing, AU - Xu,Qian, AU - Zhou,Xiao-Yu, AU - Zhang,Rui, AU - Zou,Li-Bo, Y1 - 2014/05/05/ PY - 2014/01/21/received PY - 2014/04/18/revised PY - 2014/04/24/accepted PY - 2014/5/10/entrez PY - 2014/5/9/pubmed PY - 2014/12/19/medline KW - Amyloid precursor protein KW - Aβ KW - Glycogen synthase kinase 3β KW - Hyperphosphorylated tau KW - Xanthoceraside SP - 58 EP - 63 JF - Neuroscience letters JO - Neurosci. Lett. VL - 573 N2 - Xanthoceraside, a triterpenoid saponin, has been shown to reverse cognitive deficits in several Alzheimer's disease (AD) animal models. However, the effects of xanthoceraside on the Aβ deposition pathology and the APP processing in AD are unclear. Here, we show that xanthoceraside at doses of 0.08 and 0.32 mg/kg/d for 6 months significantly improved learning and memory impairment in APP transgenic mice assessed by the Y maze and novel object recognition tests. Immunohistochemical analyses revealed that xanthoceraside strongly attenuated β-amyloid deposition in the brains of APP transgenic mice. Western blotting revealed that xanthoceraside decreased tau phosphorylation protein levels at Ser396 and Ser404 in the hippocampus; xanthoceraside also decreased APP protein levels and GSK-3β phosphorylation. These results suggest that xanthoceraside could be a promising novel candidate for the therapy of AD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24810883/Xanthoceraside_rescues_learning_and_memory_deficits_through_attenuating_beta_amyloid_deposition_and_tau_hyperphosphorylation_in_APP_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(14)00343-7 DB - PRIME DP - Unbound Medicine ER -