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Thiamin deficiency and heart failure: the current knowledge and gaps in literature.
Heart Fail Rev. 2015 Jan; 20(1):1-11.HF

Abstract

The management of heart failure (HF) represents a significant challenge for both patients as well as the healthcare system in industrialized countries. Thiamin is a required coenzyme in the energy-producing reactions that fuel myocardial contraction. Therefore, thiamin deficiency (TD) may contribute to myocardial weakness by limiting the energy available for contraction. Previous studies have reported a wide range in the prevalence of TD in patients with HF (3-91 %). The impact of thiamin supplementation in patients with HF is inconclusive. Studies conducted to date are limited by their small sample size, indirect methods of assessing thiamin concentration, methodological inconsistencies, use of impractical means of thiamin supplementation, a focus on hospitalized patients, and lack a robust technique for the assessment of cardiac function. Future large prospective studies and randomized controlled trials are needed to improve our understanding of any change in nutritional requirements associated with chronic disease as well as the clinical benefit of supplementation.

Authors+Show Affiliations

Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada, mavz.ahmed@utoronto.ca.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24811895

Citation

Ahmed, Mavra, et al. "Thiamin Deficiency and Heart Failure: the Current Knowledge and Gaps in Literature." Heart Failure Reviews, vol. 20, no. 1, 2015, pp. 1-11.
Ahmed M, Azizi-Namini P, Yan AT, et al. Thiamin deficiency and heart failure: the current knowledge and gaps in literature. Heart Fail Rev. 2015;20(1):1-11.
Ahmed, M., Azizi-Namini, P., Yan, A. T., & Keith, M. (2015). Thiamin deficiency and heart failure: the current knowledge and gaps in literature. Heart Failure Reviews, 20(1), 1-11. https://doi.org/10.1007/s10741-014-9432-0
Ahmed M, et al. Thiamin Deficiency and Heart Failure: the Current Knowledge and Gaps in Literature. Heart Fail Rev. 2015;20(1):1-11. PubMed PMID: 24811895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thiamin deficiency and heart failure: the current knowledge and gaps in literature. AU - Ahmed,Mavra, AU - Azizi-Namini,Parastoo, AU - Yan,Andrew T, AU - Keith,Mary, PY - 2014/5/10/entrez PY - 2014/5/9/pubmed PY - 2015/9/15/medline SP - 1 EP - 11 JF - Heart failure reviews JO - Heart Fail Rev VL - 20 IS - 1 N2 - The management of heart failure (HF) represents a significant challenge for both patients as well as the healthcare system in industrialized countries. Thiamin is a required coenzyme in the energy-producing reactions that fuel myocardial contraction. Therefore, thiamin deficiency (TD) may contribute to myocardial weakness by limiting the energy available for contraction. Previous studies have reported a wide range in the prevalence of TD in patients with HF (3-91 %). The impact of thiamin supplementation in patients with HF is inconclusive. Studies conducted to date are limited by their small sample size, indirect methods of assessing thiamin concentration, methodological inconsistencies, use of impractical means of thiamin supplementation, a focus on hospitalized patients, and lack a robust technique for the assessment of cardiac function. Future large prospective studies and randomized controlled trials are needed to improve our understanding of any change in nutritional requirements associated with chronic disease as well as the clinical benefit of supplementation. SN - 1573-7322 UR - https://www.unboundmedicine.com/medline/citation/24811895/Thiamin_deficiency_and_heart_failure:_the_current_knowledge_and_gaps_in_literature_ L2 - https://doi.org/10.1007/s10741-014-9432-0 DB - PRIME DP - Unbound Medicine ER -