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Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men.
Hum Reprod. 2014 Jul; 29(7):1575-84.HR

Abstract

STUDY QUESTION

Is consumption of sugar-sweetened beverages (SSB) associated with semen quality?

SUMMARY ANSWER

Higher consumption of SSB was associated with lower sperm motility among healthy, young men.

WHAT IS KNOWN ALREADY

The existing literature on the potential role of SSBs on male reproductive function is scarce and primarily focused on the relation between caffeinated beverages and semen quality. However, a rodent model suggests that SSBs may hamper male fertility.

STUDY DESIGN, SIZE, DURATION

The Rochester Young Men's Study; a cross-sectional study of 189 healthy young men carried out at the University of Rochester during 2009-2010.

PARTICIPANTS/MATERIALS, SETTING, METHODS

Men aged 18-22 years provided semen and blood samples, underwent a physical examination and completed a previously validated food frequency questionnaire (FFQ). Linear regression was used to analyze the association of SSBs with sperm parameters and reproductive hormone levels while adjusting for potential confounders.

MAIN RESULTS AND THE ROLE OF CHANCE

SSB intake was inversely related to progressive sperm motility. Men in the highest quartile of SSB intake (≥1.3 serving/day) had 9.8 (95% CI: 1.9,17.8) percentage units lower progressive sperm motility than men in the lowest quartile of intake (<0.2 serving/day) (P, trend = 0.03). This association was stronger among lean men (P, trend = 0.005) but absent among overweight or obese men (P, trend = 0.98). SSB intake was unrelated to other semen quality parameters or reproductive hormones levels.

LIMITATIONS, REASONS FOR CAUTION

As in all cross-sectional studies, causal inference is limited. An additional problem is that only single semen sample was obtained from each subject.

WIDER IMPLICATIONS OF THE FINDINGS

To our knowledge, this is the first report on the relation between SSB intake and low semen quality beyond the contribution of caffeinated beverages. While our findings are in agreement with recent experimental data in rodents, more studies are required to draw conclusions on the relation of SSB with semen quality or male infertility.

STUDY FUNDING/COMPETING INTEREST(S)

Supported by the European Union Seventh Framework Program (Environment), 'Developmental Effects of Environment on Reproductive Health' (DEER) grant 212844. Grant P30 DK046200 and Ruth L. Kirschstein National Research Service Award T32 DK007703-16 and T32HD060454 from the National Institutes of Health. None of the authors has any conflicts of interest to declare.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24812311

Citation

Chiu, Y H., et al. "Sugar-sweetened Beverage Intake in Relation to Semen Quality and Reproductive Hormone Levels in Young Men." Human Reproduction (Oxford, England), vol. 29, no. 7, 2014, pp. 1575-84.
Chiu YH, Afeiche MC, Gaskins AJ, et al. Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men. Hum Reprod. 2014;29(7):1575-84.
Chiu, Y. H., Afeiche, M. C., Gaskins, A. J., Williams, P. L., Mendiola, J., Jørgensen, N., Swan, S. H., & Chavarro, J. E. (2014). Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men. Human Reproduction (Oxford, England), 29(7), 1575-84.
Chiu YH, et al. Sugar-sweetened Beverage Intake in Relation to Semen Quality and Reproductive Hormone Levels in Young Men. Hum Reprod. 2014;29(7):1575-84. PubMed PMID: 24812311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men. AU - Chiu,Y H, AU - Afeiche,M C, AU - Gaskins,A J, AU - Williams,P L, AU - Mendiola,J, AU - Jørgensen,N, AU - Swan,S H, AU - Chavarro,J E, Y1 - 2014/05/08/ PY - 2014/5/10/entrez PY - 2014/5/9/pubmed PY - 2015/4/4/medline SP - 1575 EP - 84 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 29 IS - 7 N2 - STUDY QUESTION: Is consumption of sugar-sweetened beverages (SSB) associated with semen quality? SUMMARY ANSWER: Higher consumption of SSB was associated with lower sperm motility among healthy, young men. WHAT IS KNOWN ALREADY: The existing literature on the potential role of SSBs on male reproductive function is scarce and primarily focused on the relation between caffeinated beverages and semen quality. However, a rodent model suggests that SSBs may hamper male fertility. STUDY DESIGN, SIZE, DURATION: The Rochester Young Men's Study; a cross-sectional study of 189 healthy young men carried out at the University of Rochester during 2009-2010. PARTICIPANTS/MATERIALS, SETTING, METHODS: Men aged 18-22 years provided semen and blood samples, underwent a physical examination and completed a previously validated food frequency questionnaire (FFQ). Linear regression was used to analyze the association of SSBs with sperm parameters and reproductive hormone levels while adjusting for potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE: SSB intake was inversely related to progressive sperm motility. Men in the highest quartile of SSB intake (≥1.3 serving/day) had 9.8 (95% CI: 1.9,17.8) percentage units lower progressive sperm motility than men in the lowest quartile of intake (<0.2 serving/day) (P, trend = 0.03). This association was stronger among lean men (P, trend = 0.005) but absent among overweight or obese men (P, trend = 0.98). SSB intake was unrelated to other semen quality parameters or reproductive hormones levels. LIMITATIONS, REASONS FOR CAUTION: As in all cross-sectional studies, causal inference is limited. An additional problem is that only single semen sample was obtained from each subject. WIDER IMPLICATIONS OF THE FINDINGS: To our knowledge, this is the first report on the relation between SSB intake and low semen quality beyond the contribution of caffeinated beverages. While our findings are in agreement with recent experimental data in rodents, more studies are required to draw conclusions on the relation of SSB with semen quality or male infertility. STUDY FUNDING/COMPETING INTEREST(S): Supported by the European Union Seventh Framework Program (Environment), 'Developmental Effects of Environment on Reproductive Health' (DEER) grant 212844. Grant P30 DK046200 and Ruth L. Kirschstein National Research Service Award T32 DK007703-16 and T32HD060454 from the National Institutes of Health. None of the authors has any conflicts of interest to declare. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/24812311/Sugar_sweetened_beverage_intake_in_relation_to_semen_quality_and_reproductive_hormone_levels_in_young_men_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deu102 DB - PRIME DP - Unbound Medicine ER -