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Serum 25-hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns.
Rheumatology (Oxford). 2014 Oct; 53(10):1778-82.R

Abstract

OBJECTIVE

The aim of this study was to investigate whether low levels of serum 25-hydroxyvitamin D [25(OH)D] predicts the development of knee or hip OA.

METHODS

The cohort consisted of 5274 participants in a national health examination survey who had no knee or hip OA at baseline. Information about the incidence of OA was drawn from the National Health Care Register. During the follow-up of 10 years (50 134 person-years), 127 subjects developed incident, physician-diagnosed OA in the knee and 45 in the hip joint. The information on covariates, including age, sex, education, BMI, work load, leisure time physical activity, smoking history, knee or hip complaint during the past month and previous injuries, was gathered at baseline. Serum 25(OH)D concentrations were determined from baseline serum samples.

RESULTS

After adjustment for age and gender, serum 25(OH)D showed statistically significant associations with known risk factors for OA except injuries. In the fully adjusted model, low serum 25(OH)D concentration did not predict increased incidence of knee and hip OA.

CONCLUSION

The results do not support the hypothesis that low levels of serum 25(OH)D contribute to the development of knee or hip OA.

Authors+Show Affiliations

Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. sanna.konstari@student.oulu.fi.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24817700

Citation

Konstari, Sanna, et al. "Serum 25-hydroxyvitamin D and the Risk of Knee and Hip Osteoarthritis Leading to Hospitalization: a Cohort Study of 5274 Finns." Rheumatology (Oxford, England), vol. 53, no. 10, 2014, pp. 1778-82.
Konstari S, Kaila-Kangas L, Jääskeläinen T, et al. Serum 25-hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns. Rheumatology (Oxford). 2014;53(10):1778-82.
Konstari, S., Kaila-Kangas, L., Jääskeläinen, T., Heliövaara, M., Rissanen, H., Marniemi, J., Knekt, P., Arokoski, J., & Karppinen, J. (2014). Serum 25-hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns. Rheumatology (Oxford, England), 53(10), 1778-82. https://doi.org/10.1093/rheumatology/keu178
Konstari S, et al. Serum 25-hydroxyvitamin D and the Risk of Knee and Hip Osteoarthritis Leading to Hospitalization: a Cohort Study of 5274 Finns. Rheumatology (Oxford). 2014;53(10):1778-82. PubMed PMID: 24817700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns. AU - Konstari,Sanna, AU - Kaila-Kangas,Leena, AU - Jääskeläinen,Tuija, AU - Heliövaara,Markku, AU - Rissanen,Harri, AU - Marniemi,Jukka, AU - Knekt,Paul, AU - Arokoski,Jari, AU - Karppinen,Jaro, Y1 - 2014/05/09/ PY - 2014/5/13/entrez PY - 2014/5/13/pubmed PY - 2015/1/24/medline KW - cohort study KW - hip joint KW - knee joint KW - osteoarthritis KW - risk factors KW - serum vitamin D SP - 1778 EP - 82 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 53 IS - 10 N2 - OBJECTIVE: The aim of this study was to investigate whether low levels of serum 25-hydroxyvitamin D [25(OH)D] predicts the development of knee or hip OA. METHODS: The cohort consisted of 5274 participants in a national health examination survey who had no knee or hip OA at baseline. Information about the incidence of OA was drawn from the National Health Care Register. During the follow-up of 10 years (50 134 person-years), 127 subjects developed incident, physician-diagnosed OA in the knee and 45 in the hip joint. The information on covariates, including age, sex, education, BMI, work load, leisure time physical activity, smoking history, knee or hip complaint during the past month and previous injuries, was gathered at baseline. Serum 25(OH)D concentrations were determined from baseline serum samples. RESULTS: After adjustment for age and gender, serum 25(OH)D showed statistically significant associations with known risk factors for OA except injuries. In the fully adjusted model, low serum 25(OH)D concentration did not predict increased incidence of knee and hip OA. CONCLUSION: The results do not support the hypothesis that low levels of serum 25(OH)D contribute to the development of knee or hip OA. SN - 1462-0332 UR - https://www.unboundmedicine.com/medline/citation/24817700/Serum_25_hydroxyvitamin_D_and_the_risk_of_knee_and_hip_osteoarthritis_leading_to_hospitalization:_a_cohort_study_of_5274_Finns_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/keu178 DB - PRIME DP - Unbound Medicine ER -