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[Effect of electroacupuncture intervention at different time-points of post-modeling on hippocampal monoamine neurotransmitter levels in mice with vascular dementia].
Zhen Ci Yan Jiu. 2014 Apr; 39(2):142-7.ZC

Abstract

OBJECTIVE

To observe the effect of electrocupuncture (EA) intervention at different time-points of post-modeling on behavior and hippocampal monoamine neurotransmitter noradrenalin (NE), dopamine (DA) and 5-hydroxytrypamine (5-HT) contents in vascular dementia (VD) mice, so as to study its mechanism underlying improvement of VD.

METHODS

A total of 60 Kunming mice were randomized into sham-operation control (n = 20), VD model (n = 20), EA-day (D)-1 (EA treatment was given from the 1st day on after modeling, n = 10), EA-D-3 (EA was given from the 3rd day on after modeling, n = 10) groups. VD model was established by occlusion of the bilateral cervical common arteries and reperfusion. EA (2 Hz/80 Hz) was applied to "Baihui" (GV 20), "Dazhui" (GV 14),"Zusanli" (ST 36) and "Geshu"(BL 17) for 10 min, once daily for 15 days. Hippocampal NE, DA and 5-HT contents were assayed by fluorospectrophotometry. The mouse's learning-memory ability was assessed by step-down tests.

RESULTS

In comparison with the sham-operation control group, the learning-memory ability (marked increase of reaction time and error times, decrease of step-down latency) was apparently lowered in the model group (P < 0.01). The hippocampal NE, DA and 5-HT contents were significantly lower in the model group than in the sham-operation group (P < 0.01). Compared with the model group, the mice's learning-memory ability (marked decrease of reaction time and error times, increase of step-down latency) was significantly increased in EA intervention groups (P < 0.01), and hippocampal NE, DA and 5-HT levels were significantly increased (P < 0.01), and the effect of EA-D-3 group was obviously better than that of the EA-D-1 group (P < 0.05, P < 0.01).

CONCLUSION

EA can improve the VD mice's learning-memory ability, which is closely related to its effects in up-regulating hippocampal NE, DA and 5-HT contents, and the effect of later EA intervention after modeling is better.

Authors

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Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24818499

Citation

Zhang, Hui-Zhen, et al. "[Effect of Electroacupuncture Intervention at Different Time-points of Post-modeling On Hippocampal Monoamine Neurotransmitter Levels in Mice With Vascular Dementia]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 39, no. 2, 2014, pp. 142-7.
Zhang HZ, Liang YL, Zhang XJ, et al. [Effect of electroacupuncture intervention at different time-points of post-modeling on hippocampal monoamine neurotransmitter levels in mice with vascular dementia]. Zhen Ci Yan Jiu. 2014;39(2):142-7.
Zhang, H. Z., Liang, Y. L., Zhang, X. J., Zhang, C., Sun, Y. H., Zhang, X. J., Xu, X. K., Jia, R. G., & Wang, X. G. (2014). [Effect of electroacupuncture intervention at different time-points of post-modeling on hippocampal monoamine neurotransmitter levels in mice with vascular dementia]. Zhen Ci Yan Jiu = Acupuncture Research, 39(2), 142-7.
Zhang HZ, et al. [Effect of Electroacupuncture Intervention at Different Time-points of Post-modeling On Hippocampal Monoamine Neurotransmitter Levels in Mice With Vascular Dementia]. Zhen Ci Yan Jiu. 2014;39(2):142-7. PubMed PMID: 24818499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of electroacupuncture intervention at different time-points of post-modeling on hippocampal monoamine neurotransmitter levels in mice with vascular dementia]. AU - Zhang,Hui-Zhen, AU - Liang,Yu-Lei, AU - Zhang,Xue-Jing, AU - Zhang,Chuang, AU - Sun,Yan-Hui, AU - Zhang,Xiu-Jing, AU - Xu,Xiao-Kang, AU - Jia,Rui-Guo, AU - Wang,Xin-Guo, PY - 2014/5/14/entrez PY - 2014/5/14/pubmed PY - 2014/6/18/medline SP - 142 EP - 7 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 39 IS - 2 N2 - OBJECTIVE: To observe the effect of electrocupuncture (EA) intervention at different time-points of post-modeling on behavior and hippocampal monoamine neurotransmitter noradrenalin (NE), dopamine (DA) and 5-hydroxytrypamine (5-HT) contents in vascular dementia (VD) mice, so as to study its mechanism underlying improvement of VD. METHODS: A total of 60 Kunming mice were randomized into sham-operation control (n = 20), VD model (n = 20), EA-day (D)-1 (EA treatment was given from the 1st day on after modeling, n = 10), EA-D-3 (EA was given from the 3rd day on after modeling, n = 10) groups. VD model was established by occlusion of the bilateral cervical common arteries and reperfusion. EA (2 Hz/80 Hz) was applied to "Baihui" (GV 20), "Dazhui" (GV 14),"Zusanli" (ST 36) and "Geshu"(BL 17) for 10 min, once daily for 15 days. Hippocampal NE, DA and 5-HT contents were assayed by fluorospectrophotometry. The mouse's learning-memory ability was assessed by step-down tests. RESULTS: In comparison with the sham-operation control group, the learning-memory ability (marked increase of reaction time and error times, decrease of step-down latency) was apparently lowered in the model group (P < 0.01). The hippocampal NE, DA and 5-HT contents were significantly lower in the model group than in the sham-operation group (P < 0.01). Compared with the model group, the mice's learning-memory ability (marked decrease of reaction time and error times, increase of step-down latency) was significantly increased in EA intervention groups (P < 0.01), and hippocampal NE, DA and 5-HT levels were significantly increased (P < 0.01), and the effect of EA-D-3 group was obviously better than that of the EA-D-1 group (P < 0.05, P < 0.01). CONCLUSION: EA can improve the VD mice's learning-memory ability, which is closely related to its effects in up-regulating hippocampal NE, DA and 5-HT contents, and the effect of later EA intervention after modeling is better. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/24818499/[Effect_of_electroacupuncture_intervention_at_different_time_points_of_post_modeling_on_hippocampal_monoamine_neurotransmitter_levels_in_mice_with_vascular_dementia]_ DB - PRIME DP - Unbound Medicine ER -