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Methicillin-resistant Staphylococcus aureus colonization and disease severity in atopic dermatitis: a cross-sectional study from South India.
Indian J Dermatol Venereol Leprol. 2014 May-Jun; 80(3):229-34.IJ

Abstract

BACKGROUND

Colonization by methicillin-resistant Staphylococcus aureus (MRSA) in atopic dermatitis is little studied but has therapeutic implications. It may have a role in disease severity given the additional virulence factors associated.

AIMS

Our aims were to record the proportion of patients with MRSA colonization in atopic dermatitis and to ascertain if any association exists between MRSA colonization and disease severity.

METHODS

An observational cross-sectional study involving children aged≤12 years with atopic dermatitis attending the outpatient department of Government Medical College, Kottayam was conducted. Socio-demographic data, exacerbating factors and risk factors for hospital care-associated MRSA were documented. Extent of atopic dermatitis was recorded using a standardized scale (Eczema Area Severity Index, EASI). Skin swabs were taken from anterior nares and the worst affected atopic dermatitis sites for culture and sensitivity.

RESULTS

Of the 119 subjects recruited during the study period (November 2009-April 2011), Staphylococcus aureus was isolated from 110 (92.4%) patients and MRSA from 30 (25.21%) patients. A total of 18 patients with MRSA had risk factors for healthcare associated-MRSA. The patients whose cultures grew MRSA were found to have significantly higher EASI score when compared to those patients colonized with methicillin sensitive Staphylococcus aureus (P < 0.01). Presence of Staphylococcus aureus, early age of onset, presence of food allergies, seasonal exacerbation and inadequate breastfeeding did not seem to influence disease severity.

CONCLUSIONS

There is a high degree of prevalence of MRSA (25.2%) in atopic dermatitis and presence of MRSA is associated with increased disease severity. Further studies are needed to validate these findings.

Authors+Show Affiliations

No affiliation info availableDepartment of Dermatology and Venereology, Government Medical College, Kottayam, Kerala, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24823400

Citation

Jagadeesan, Soumya, et al. "Methicillin-resistant Staphylococcus Aureus Colonization and Disease Severity in Atopic Dermatitis: a Cross-sectional Study From South India." Indian Journal of Dermatology, Venereology and Leprology, vol. 80, no. 3, 2014, pp. 229-34.
Jagadeesan S, Kurien G, Divakaran MV, et al. Methicillin-resistant Staphylococcus aureus colonization and disease severity in atopic dermatitis: a cross-sectional study from South India. Indian J Dermatol Venereol Leprol. 2014;80(3):229-34.
Jagadeesan, S., Kurien, G., Divakaran, M. V., Sadanandan, S. M., Sobhanakumari, K., & Sarin, A. (2014). Methicillin-resistant Staphylococcus aureus colonization and disease severity in atopic dermatitis: a cross-sectional study from South India. Indian Journal of Dermatology, Venereology and Leprology, 80(3), 229-34. https://doi.org/10.4103/0378-6323.132250
Jagadeesan S, et al. Methicillin-resistant Staphylococcus Aureus Colonization and Disease Severity in Atopic Dermatitis: a Cross-sectional Study From South India. Indian J Dermatol Venereol Leprol. 2014 May-Jun;80(3):229-34. PubMed PMID: 24823400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methicillin-resistant Staphylococcus aureus colonization and disease severity in atopic dermatitis: a cross-sectional study from South India. AU - Jagadeesan,Soumya, AU - Kurien,George, AU - Divakaran,Manjula Velikkakathu, AU - Sadanandan,Sadeep Melethil, AU - Sobhanakumari,K, AU - Sarin,A, PY - 2014/5/15/entrez PY - 2014/5/16/pubmed PY - 2014/12/30/medline SP - 229 EP - 34 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 80 IS - 3 N2 - BACKGROUND: Colonization by methicillin-resistant Staphylococcus aureus (MRSA) in atopic dermatitis is little studied but has therapeutic implications. It may have a role in disease severity given the additional virulence factors associated. AIMS: Our aims were to record the proportion of patients with MRSA colonization in atopic dermatitis and to ascertain if any association exists between MRSA colonization and disease severity. METHODS: An observational cross-sectional study involving children aged≤12 years with atopic dermatitis attending the outpatient department of Government Medical College, Kottayam was conducted. Socio-demographic data, exacerbating factors and risk factors for hospital care-associated MRSA were documented. Extent of atopic dermatitis was recorded using a standardized scale (Eczema Area Severity Index, EASI). Skin swabs were taken from anterior nares and the worst affected atopic dermatitis sites for culture and sensitivity. RESULTS: Of the 119 subjects recruited during the study period (November 2009-April 2011), Staphylococcus aureus was isolated from 110 (92.4%) patients and MRSA from 30 (25.21%) patients. A total of 18 patients with MRSA had risk factors for healthcare associated-MRSA. The patients whose cultures grew MRSA were found to have significantly higher EASI score when compared to those patients colonized with methicillin sensitive Staphylococcus aureus (P < 0.01). Presence of Staphylococcus aureus, early age of onset, presence of food allergies, seasonal exacerbation and inadequate breastfeeding did not seem to influence disease severity. CONCLUSIONS: There is a high degree of prevalence of MRSA (25.2%) in atopic dermatitis and presence of MRSA is associated with increased disease severity. Further studies are needed to validate these findings. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/24823400/Methicillin_resistant_Staphylococcus_aureus_colonization_and_disease_severity_in_atopic_dermatitis:_a_cross_sectional_study_from_South_India_ DB - PRIME DP - Unbound Medicine ER -