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Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance.
Cancer Prev Res (Phila). 2014 Jul; 7(7):766-76.CP

Abstract

The association between omega-3 (ω-3) fatty acids and prostate cancer has been widely studied. However, little is known about the impact of prostate tissue fatty acid content on prostate cancer progression. We hypothesized that compared with the estimated dietary ω-3 fatty acids intake and the ω-3 fatty acids levels measured in red blood cells (RBC), the prostate tissue ω-3 fatty acid content is more strongly related to prostate cancer progression. We present the initial observations from baseline data of a phase II clinical trial conducted in a cohort of 48 untreated men affected with low-risk prostate cancer, managed under active surveillance. These men underwent a first repeat biopsy session within 6 months after the initial diagnosis of low-risk prostate cancer, at which time 29% of the men had progressed from a Gleason score of 6 to a Gleason score of 7. At the first repeat biopsy session, fatty acid levels were assessed with a food-frequency questionnaire, and determined in the RBC and in the prostate tissue biopsy. We found that eicosapentaenoic acid (EPA) was associated with a reduced risk of prostate cancer progression when measured directly in the prostate tissue. Thus, this initial interim study analysis suggests that prostate tissue ω-3 fatty acids, especially EPA, may be protective against prostate cancer progression in men with low-risk prostate cancer.

Authors+Show Affiliations

Authors' Affiliations: Department of Surgery (Urology), CHU de Québec-L'Hôtel-Dieu de Quebec, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada;Authors' Affiliations: Department of Surgery (Urology), CHU de Québec-L'Hôtel-Dieu de Quebec, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada;Authors' Affiliations: Department of Surgery (Urology), CHU de Québec-L'Hôtel-Dieu de Quebec, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada;Authors' Affiliations: Department of Surgery (Urology), CHU de Québec-L'Hôtel-Dieu de Quebec, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada;Institute of Nutrition and Functional Foods, Laval University, Quebec, Canada;Institute of Nutrition and Functional Foods, Laval University, Quebec, Canada;CHU de Quebec Research Center, Endocrinology and Nephrology Axis, Laval University, Quebec, Canada; and.Department of Pathology, CHU de Quebec-Hôpital Saint-Sacrement, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada.Department of Pathology, CHU de Quebec-Hôpital Saint-Sacrement, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada.Authors' Affiliations: Department of Surgery (Urology), CHU de Québec-L'Hôtel-Dieu de Quebec, Quebec, Canada and CHU de Quebec Research Center, Oncology Axis, Laval University, Quebec, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec, Canada; vincent.fradet@fmed.ulaval.ca.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24824038

Citation

Moreel, Xavier, et al. "Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression During Active Surveillance." Cancer Prevention Research (Philadelphia, Pa.), vol. 7, no. 7, 2014, pp. 766-76.
Moreel X, Allaire J, Léger C, et al. Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance. Cancer Prev Res (Phila). 2014;7(7):766-76.
Moreel, X., Allaire, J., Léger, C., Caron, A., Labonté, M. È., Lamarche, B., Julien, P., Desmeules, P., Têtu, B., & Fradet, V. (2014). Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance. Cancer Prevention Research (Philadelphia, Pa.), 7(7), 766-76. https://doi.org/10.1158/1940-6207.CAPR-13-0349
Moreel X, et al. Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression During Active Surveillance. Cancer Prev Res (Phila). 2014;7(7):766-76. PubMed PMID: 24824038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance. AU - Moreel,Xavier, AU - Allaire,Janie, AU - Léger,Caroline, AU - Caron,André, AU - Labonté,Marie-Ève, AU - Lamarche,Benoît, AU - Julien,Pierre, AU - Desmeules,Patrice, AU - Têtu,Bernard, AU - Fradet,Vincent, Y1 - 2014/05/13/ PY - 2014/5/15/entrez PY - 2014/5/16/pubmed PY - 2015/2/14/medline SP - 766 EP - 76 JF - Cancer prevention research (Philadelphia, Pa.) JO - Cancer Prev Res (Phila) VL - 7 IS - 7 N2 - The association between omega-3 (ω-3) fatty acids and prostate cancer has been widely studied. However, little is known about the impact of prostate tissue fatty acid content on prostate cancer progression. We hypothesized that compared with the estimated dietary ω-3 fatty acids intake and the ω-3 fatty acids levels measured in red blood cells (RBC), the prostate tissue ω-3 fatty acid content is more strongly related to prostate cancer progression. We present the initial observations from baseline data of a phase II clinical trial conducted in a cohort of 48 untreated men affected with low-risk prostate cancer, managed under active surveillance. These men underwent a first repeat biopsy session within 6 months after the initial diagnosis of low-risk prostate cancer, at which time 29% of the men had progressed from a Gleason score of 6 to a Gleason score of 7. At the first repeat biopsy session, fatty acid levels were assessed with a food-frequency questionnaire, and determined in the RBC and in the prostate tissue biopsy. We found that eicosapentaenoic acid (EPA) was associated with a reduced risk of prostate cancer progression when measured directly in the prostate tissue. Thus, this initial interim study analysis suggests that prostate tissue ω-3 fatty acids, especially EPA, may be protective against prostate cancer progression in men with low-risk prostate cancer. SN - 1940-6215 UR - https://www.unboundmedicine.com/medline/citation/24824038/Prostatic_and_dietary_omega_3_fatty_acids_and_prostate_cancer_progression_during_active_surveillance_ L2 - http://cancerpreventionresearch.aacrjournals.org/cgi/pmidlookup?view=long&pmid=24824038 DB - PRIME DP - Unbound Medicine ER -