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Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study.
BJOG. 2015 Feb; 122(3):322-8.BJOG

Abstract

OBJECTIVE

To study the associations of prenatal blood lead levels (B-Pb) with pregnancy outcomes in a large cohort of mother-child pairs in the UK.

DESIGN

Prospective birth cohort study.

SETTING

Avon area of Bristol, UK.

POPULATION

Pregnant women enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC).

METHODS

Whole blood samples were collected and analysed by inductively coupled plasma dynamic reaction cell mass spectrometry (n = 4285). Data collected on the infants included anthropometric variables and gestational age at delivery. Linear regression models for continuous outcomes and logistic regression models for categorical outcomes were adjusted for covariates including maternal height, smoking, parity, sex of the baby and gestational age.

MAIN OUTCOME MEASURES

Birthweight, head circumference and crown-heel length, preterm delivery and low birthweight.

RESULTS

The mean blood lead level (B-Pb) was 3.67 ± 1.47 μg/dl. B-Pb ≥ 5 μg/dl significantly increased the risk of preterm delivery (adjusted odds ratio [OR] 2.00 95% confidence interval [95% CI] 1.35-3.00) but not of having a low birthweight baby (adjusted OR 1.37, 95% CI 0.86-2.18) in multivariable binary logistic models. Increasing B-Pb was significantly associated with reductions in birth weight (β -13.23, 95% CI -23.75 to -2.70), head circumference (β -0.04, 95% CI -0.07 to -0.06) and crown-heel length (β -0.05, 95% CI -0.10 to -0.00) in multivariable linear regression models.

CONCLUSIONS

There was evidence for adverse effects of maternal B-Pb on the incidence of preterm delivery, birthweight, head circumference and crown-heel length, but not on the incidence of low birthweight, in this group of women.

Authors+Show Affiliations

Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24824048

Citation

Taylor, C M., et al. "Adverse Effects of Maternal Lead Levels On Birth Outcomes in the ALSPAC Study: a Prospective Birth Cohort Study." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, 2015, pp. 322-8.
Taylor CM, Golding J, Emond AM. Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study. BJOG. 2015;122(3):322-8.
Taylor, C. M., Golding, J., & Emond, A. M. (2015). Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study. BJOG : an International Journal of Obstetrics and Gynaecology, 122(3), 322-8. https://doi.org/10.1111/1471-0528.12756
Taylor CM, Golding J, Emond AM. Adverse Effects of Maternal Lead Levels On Birth Outcomes in the ALSPAC Study: a Prospective Birth Cohort Study. BJOG. 2015;122(3):322-8. PubMed PMID: 24824048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study. AU - Taylor,C M, AU - Golding,J, AU - Emond,A M, Y1 - 2014/05/14/ PY - 2014/02/12/accepted PY - 2014/5/15/entrez PY - 2014/5/16/pubmed PY - 2015/5/16/medline KW - Birthweight KW - head circumference KW - lead KW - low birthweight KW - pregnancy KW - preterm SP - 322 EP - 8 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 122 IS - 3 N2 - OBJECTIVE: To study the associations of prenatal blood lead levels (B-Pb) with pregnancy outcomes in a large cohort of mother-child pairs in the UK. DESIGN: Prospective birth cohort study. SETTING: Avon area of Bristol, UK. POPULATION: Pregnant women enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). METHODS: Whole blood samples were collected and analysed by inductively coupled plasma dynamic reaction cell mass spectrometry (n = 4285). Data collected on the infants included anthropometric variables and gestational age at delivery. Linear regression models for continuous outcomes and logistic regression models for categorical outcomes were adjusted for covariates including maternal height, smoking, parity, sex of the baby and gestational age. MAIN OUTCOME MEASURES: Birthweight, head circumference and crown-heel length, preterm delivery and low birthweight. RESULTS: The mean blood lead level (B-Pb) was 3.67 ± 1.47 μg/dl. B-Pb ≥ 5 μg/dl significantly increased the risk of preterm delivery (adjusted odds ratio [OR] 2.00 95% confidence interval [95% CI] 1.35-3.00) but not of having a low birthweight baby (adjusted OR 1.37, 95% CI 0.86-2.18) in multivariable binary logistic models. Increasing B-Pb was significantly associated with reductions in birth weight (β -13.23, 95% CI -23.75 to -2.70), head circumference (β -0.04, 95% CI -0.07 to -0.06) and crown-heel length (β -0.05, 95% CI -0.10 to -0.00) in multivariable linear regression models. CONCLUSIONS: There was evidence for adverse effects of maternal B-Pb on the incidence of preterm delivery, birthweight, head circumference and crown-heel length, but not on the incidence of low birthweight, in this group of women. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/24824048/Adverse_effects_of_maternal_lead_levels_on_birth_outcomes_in_the_ALSPAC_study:_a_prospective_birth_cohort_study_ L2 - https://doi.org/10.1111/1471-0528.12756 DB - PRIME DP - Unbound Medicine ER -