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[Expression of class I and class II histocompatibility antigens in inflammatory kidney diseases].
Verh Dtsch Ges Pathol. 1989; 73:117-23.VD

Abstract

MHC class I and II molecules serve as restriction elements for the presentation of antigen-specific T cell reactions and may be implicated in the process of cellular transformation. We have analysed the expression of MHC class I and II antigens including the associated invariant gamma-chain in 100 consecutive renal biopsies by a sensitive immunoperoxidase method using monoclonal antibodies against HLA-ABC, HLA-DR, HLA-DQ, HLA-DP and the invariant gamma-chain (Ii). HLA-ABC was expressed by almost all parenchymal cells except for podocytes. Staining for HLA-DR was found consistently in glomerular and interstitial capillary endothelial cells, in "dendritic" (LCA positive) and most infiltrating interstitial cells but not in mesangial and most extracapillary cells. Similar but weaker positivity was observed for HLA-DQ and -DP. HLA-DR positive infiltrating mononuclear cells in glomeruli were noted in acute glomerulonephritis (GN) and Lupus GN associated with enhanced staining of endothelial cells. In addition, HLA-DR was uniformly or focally expressed by predominantly proximal tubules in 80% of biopsies, especially IgA-GN, focal glomerulosclerosis, acute GN but also in 54% of cases with minimal change nephrosis. HLA-DP and -DQ were only positive in a limited number of HLA-DR positive tubules. The expression of the invariant gamma-chain was comparable with the reactivity for HLA-DR. In addition, all HLA-DR-positive tubules expressed the invariant gamma-chain. Subtyping of T cells in biopsies with DR-positive tubules and interstitial infiltrates (n = 20) showed a predominance of CD 4 positive cells in the majority of cases.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

2482595

Citation

Eberlein-Gonska, M, et al. "[Expression of Class I and Class II Histocompatibility Antigens in Inflammatory Kidney Diseases]." Verhandlungen Der Deutschen Gesellschaft Fur Pathologie, vol. 73, 1989, pp. 117-23.
Eberlein-Gonska M, Sill H, Waldherr R. [Expression of class I and class II histocompatibility antigens in inflammatory kidney diseases]. Verh Dtsch Ges Pathol. 1989;73:117-23.
Eberlein-Gonska, M., Sill, H., & Waldherr, R. (1989). [Expression of class I and class II histocompatibility antigens in inflammatory kidney diseases]. Verhandlungen Der Deutschen Gesellschaft Fur Pathologie, 73, 117-23.
Eberlein-Gonska M, Sill H, Waldherr R. [Expression of Class I and Class II Histocompatibility Antigens in Inflammatory Kidney Diseases]. Verh Dtsch Ges Pathol. 1989;73:117-23. PubMed PMID: 2482595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of class I and class II histocompatibility antigens in inflammatory kidney diseases]. AU - Eberlein-Gonska,M, AU - Sill,H, AU - Waldherr,R, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 117 EP - 23 JF - Verhandlungen der Deutschen Gesellschaft fur Pathologie JO - Verh Dtsch Ges Pathol VL - 73 N2 - MHC class I and II molecules serve as restriction elements for the presentation of antigen-specific T cell reactions and may be implicated in the process of cellular transformation. We have analysed the expression of MHC class I and II antigens including the associated invariant gamma-chain in 100 consecutive renal biopsies by a sensitive immunoperoxidase method using monoclonal antibodies against HLA-ABC, HLA-DR, HLA-DQ, HLA-DP and the invariant gamma-chain (Ii). HLA-ABC was expressed by almost all parenchymal cells except for podocytes. Staining for HLA-DR was found consistently in glomerular and interstitial capillary endothelial cells, in "dendritic" (LCA positive) and most infiltrating interstitial cells but not in mesangial and most extracapillary cells. Similar but weaker positivity was observed for HLA-DQ and -DP. HLA-DR positive infiltrating mononuclear cells in glomeruli were noted in acute glomerulonephritis (GN) and Lupus GN associated with enhanced staining of endothelial cells. In addition, HLA-DR was uniformly or focally expressed by predominantly proximal tubules in 80% of biopsies, especially IgA-GN, focal glomerulosclerosis, acute GN but also in 54% of cases with minimal change nephrosis. HLA-DP and -DQ were only positive in a limited number of HLA-DR positive tubules. The expression of the invariant gamma-chain was comparable with the reactivity for HLA-DR. In addition, all HLA-DR-positive tubules expressed the invariant gamma-chain. Subtyping of T cells in biopsies with DR-positive tubules and interstitial infiltrates (n = 20) showed a predominance of CD 4 positive cells in the majority of cases.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0070-4113 UR - https://www.unboundmedicine.com/medline/citation/2482595/[Expression_of_class_I_and_class_II_histocompatibility_antigens_in_inflammatory_kidney_diseases]_ L2 - https://medlineplus.gov/kidneydiseases.html DB - PRIME DP - Unbound Medicine ER -