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Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.
Mol Nutr Food Res 2014; 58(7):1465-73MN

Abstract

SCOPE

This study was conducted to determine the effects of folate supplementation on metabolic profiles in obese women with polycystic ovary syndrome (PCOS).

METHODS AND RESULTS

This randomized double-blind placebo-controlled clinical trial was conducted among 81 obese women (weight range: 65-110 kg) aged 18-40 year old diagnosed with PCOS. Participants were randomly assigned to three groups receiving: (1) Folate-1: 1 mg/day folate supplements (n = 27); (2) Folate-5: 5 mg/day folate supplements (n = 27), and (3) placebo (n = 27) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to quantify glucose metabolism and lipid concentrations. Folate supplementation (5 mg), compared with folate-1 and placebo, resulted in reduced plasma homocysteine (p-interaction = 0.009), homeostasis model of assessment-insulin resistance score (p-interaction = 0.01), and total cholesterol/HDL-C ratio (p-interaction = 0.01). Furthermore, we found a significant difference in mean change of serum total cholesterol (p-interaction = 0.01), LDL- (p-interaction = 0.007), and non-HDL-cholesterol levels (p = 0.01) in the folate-5 group compared with folate-1 and placebo.

CONCLUSION

5 mg/day folate supplementation for 8 weeks among women with PCOS had beneficial effects on metabolic profiles.

Authors+Show Affiliations

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24828019

Citation

Asemi, Zatollah, et al. "Metabolic Response to Folate Supplementation in Overweight Women With Polycystic Ovary Syndrome: a Randomized Double-blind Placebo-controlled Clinical Trial." Molecular Nutrition & Food Research, vol. 58, no. 7, 2014, pp. 1465-73.
Asemi Z, Karamali M, Esmaillzadeh A. Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. Mol Nutr Food Res. 2014;58(7):1465-73.
Asemi, Z., Karamali, M., & Esmaillzadeh, A. (2014). Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. Molecular Nutrition & Food Research, 58(7), pp. 1465-73. doi:10.1002/mnfr.201400033.
Asemi Z, Karamali M, Esmaillzadeh A. Metabolic Response to Folate Supplementation in Overweight Women With Polycystic Ovary Syndrome: a Randomized Double-blind Placebo-controlled Clinical Trial. Mol Nutr Food Res. 2014;58(7):1465-73. PubMed PMID: 24828019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. AU - Asemi,Zatollah, AU - Karamali,Maryam, AU - Esmaillzadeh,Ahmad, Y1 - 2014/05/15/ PY - 2014/01/15/received PY - 2014/02/28/revised PY - 2014/03/11/accepted PY - 2014/5/16/entrez PY - 2014/5/16/pubmed PY - 2015/3/7/medline KW - Folate KW - Glucose metabolism KW - Lipid concentrations KW - Polycystic ovary syndrome KW - Supplementation SP - 1465 EP - 73 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 58 IS - 7 N2 - SCOPE: This study was conducted to determine the effects of folate supplementation on metabolic profiles in obese women with polycystic ovary syndrome (PCOS). METHODS AND RESULTS: This randomized double-blind placebo-controlled clinical trial was conducted among 81 obese women (weight range: 65-110 kg) aged 18-40 year old diagnosed with PCOS. Participants were randomly assigned to three groups receiving: (1) Folate-1: 1 mg/day folate supplements (n = 27); (2) Folate-5: 5 mg/day folate supplements (n = 27), and (3) placebo (n = 27) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to quantify glucose metabolism and lipid concentrations. Folate supplementation (5 mg), compared with folate-1 and placebo, resulted in reduced plasma homocysteine (p-interaction = 0.009), homeostasis model of assessment-insulin resistance score (p-interaction = 0.01), and total cholesterol/HDL-C ratio (p-interaction = 0.01). Furthermore, we found a significant difference in mean change of serum total cholesterol (p-interaction = 0.01), LDL- (p-interaction = 0.007), and non-HDL-cholesterol levels (p = 0.01) in the folate-5 group compared with folate-1 and placebo. CONCLUSION: 5 mg/day folate supplementation for 8 weeks among women with PCOS had beneficial effects on metabolic profiles. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/24828019/Metabolic_response_to_folate_supplementation_in_overweight_women_with_polycystic_ovary_syndrome:_a_randomized_double_blind_placebo_controlled_clinical_trial_ L2 - https://doi.org/10.1002/mnfr.201400033 DB - PRIME DP - Unbound Medicine ER -