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Ketosis onset type 2 diabetes had better islet β-cell function and more serious insulin resistance.
J Diabetes Res. 2014; 2014:510643.JD

Abstract

Diabetic ketosis had been identified as a characteristic of type 1 diabetes mellitus (T1DM), but now emerging evidence has identified that they were diagnosed as T2DM after long time follow up. This case control study was aimed at comparing the clinical characteristic, β-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection. 140 cases of newly diagnosed T2DM patients were divided into ketosis (62 cases) and nonketotic onset group (78 cases). After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration. Area under the curve (AUC) of C-peptide was calculated. Homoeostasis model assessment was used to estimate basal β-cell function (HOMA-β) and insulin resistance (HOMA-IR). Our results showed that ketosis onset group had higher prevalence of nonalcoholic fatty liver disease (NAFLD) than nonketotic group (P = 0.04). Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC(0-0.5), AUC₀₋₁, AUC₀₋₃ (P < 0.05). Moreover, this group also had higher HOMA-β and HOMA-IR than nonketotic group (P < 0.05). From these data, we concluded that ketosis onset T2DM had better islet β-cell function and more serious insulin resistance than nonketotic onset T2DM.

Authors+Show Affiliations

Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24829925

Citation

Lu, Hongyun, et al. "Ketosis Onset Type 2 Diabetes Had Better Islet Β-cell Function and More Serious Insulin Resistance." Journal of Diabetes Research, vol. 2014, 2014, p. 510643.
Lu H, Hu F, Zeng Y, et al. Ketosis onset type 2 diabetes had better islet β-cell function and more serious insulin resistance. J Diabetes Res. 2014;2014:510643.
Lu, H., Hu, F., Zeng, Y., Zou, L., Luo, S., Sun, Y., Liu, H., & Sun, L. (2014). Ketosis onset type 2 diabetes had better islet β-cell function and more serious insulin resistance. Journal of Diabetes Research, 2014, 510643. https://doi.org/10.1155/2014/510643
Lu H, et al. Ketosis Onset Type 2 Diabetes Had Better Islet Β-cell Function and More Serious Insulin Resistance. J Diabetes Res. 2014;2014:510643. PubMed PMID: 24829925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ketosis onset type 2 diabetes had better islet β-cell function and more serious insulin resistance. AU - Lu,Hongyun, AU - Hu,Fang, AU - Zeng,Yingjuan, AU - Zou,Lingling, AU - Luo,Shunkui, AU - Sun,Ying, AU - Liu,Hong, AU - Sun,Liao, Y1 - 2014/04/13/ PY - 2013/12/28/received PY - 2014/03/13/revised PY - 2014/03/16/accepted PY - 2014/5/16/entrez PY - 2014/5/16/pubmed PY - 2014/10/29/medline SP - 510643 EP - 510643 JF - Journal of diabetes research JO - J Diabetes Res VL - 2014 N2 - Diabetic ketosis had been identified as a characteristic of type 1 diabetes mellitus (T1DM), but now emerging evidence has identified that they were diagnosed as T2DM after long time follow up. This case control study was aimed at comparing the clinical characteristic, β-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection. 140 cases of newly diagnosed T2DM patients were divided into ketosis (62 cases) and nonketotic onset group (78 cases). After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration. Area under the curve (AUC) of C-peptide was calculated. Homoeostasis model assessment was used to estimate basal β-cell function (HOMA-β) and insulin resistance (HOMA-IR). Our results showed that ketosis onset group had higher prevalence of nonalcoholic fatty liver disease (NAFLD) than nonketotic group (P = 0.04). Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC(0-0.5), AUC₀₋₁, AUC₀₋₃ (P < 0.05). Moreover, this group also had higher HOMA-β and HOMA-IR than nonketotic group (P < 0.05). From these data, we concluded that ketosis onset T2DM had better islet β-cell function and more serious insulin resistance than nonketotic onset T2DM. SN - 2314-6753 UR - https://www.unboundmedicine.com/medline/citation/24829925/Ketosis_onset_type_2_diabetes_had_better_islet_β_cell_function_and_more_serious_insulin_resistance_ L2 - https://doi.org/10.1155/2014/510643 DB - PRIME DP - Unbound Medicine ER -