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Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma.

Abstract

BACKGROUND

Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat-soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC).

METHODS

This was a cross-sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) were measured using an enzyme-linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high-performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables.

RESULTS

Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL-6, TNF-α, and IFN-γ (P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL-6, TNF-α, and IFN-γ levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN-γ levels and serum α-tocopherol levels (P = .03).

CONCLUSIONS

Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition Sciences, University of Alabama-Birmingham, Birmingham, Alabama; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan.

    , , , , , , , , , , , ,

    Source

    Cancer 120:17 2014 Sep 01 pg 2704-12

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Biomarkers, Tumor
    Carcinoma, Squamous Cell
    Cross-Sectional Studies
    Cytokines
    Diet
    Female
    Head and Neck Neoplasms
    Humans
    Inflammation Mediators
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Squamous Cell Carcinoma of Head and Neck

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24830761

    Citation

    Arthur, Anna E., et al. "Diet and Proinflammatory Cytokine Levels in Head and Neck Squamous Cell Carcinoma." Cancer, vol. 120, no. 17, 2014, pp. 2704-12.
    Arthur AE, Peterson KE, Shen J, et al. Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma. Cancer. 2014;120(17):2704-12.
    Arthur, A. E., Peterson, K. E., Shen, J., Djuric, Z., Taylor, J. M., Hebert, J. R., ... Rozek, L. S. (2014). Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma. Cancer, 120(17), pp. 2704-12. doi:10.1002/cncr.28778.
    Arthur AE, et al. Diet and Proinflammatory Cytokine Levels in Head and Neck Squamous Cell Carcinoma. Cancer. 2014 Sep 1;120(17):2704-12. PubMed PMID: 24830761.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma. AU - Arthur,Anna E, AU - Peterson,Karen E, AU - Shen,Jincheng, AU - Djuric,Zora, AU - Taylor,Jeremy M G, AU - Hebert,James R, AU - Duffy,Sonia A, AU - Peterson,Lisa A, AU - Bellile,Emily L, AU - Whitfield,Joel R, AU - Chepeha,Douglas B, AU - Schipper,Matthew J, AU - Wolf,Gregory T, AU - Rozek,Laura S, Y1 - 2014/05/15/ PY - 2013/12/02/received PY - 2014/04/14/revised PY - 2014/04/17/accepted PY - 2014/5/17/entrez PY - 2014/5/17/pubmed PY - 2014/10/15/medline KW - carotenoids KW - cytokines KW - dietary patterns KW - head and neck cancer SP - 2704 EP - 12 JF - Cancer JO - Cancer VL - 120 IS - 17 N2 - BACKGROUND: Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat-soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC). METHODS: This was a cross-sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) were measured using an enzyme-linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high-performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables. RESULTS: Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL-6, TNF-α, and IFN-γ (P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL-6, TNF-α, and IFN-γ levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN-γ levels and serum α-tocopherol levels (P = .03). CONCLUSIONS: Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/24830761/full_citation L2 - https://doi.org/10.1002/cncr.28778 DB - PRIME DP - Unbound Medicine ER -