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Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis.
J Ovarian Res 2014; 7:41JO

Abstract

BACKGROUND

Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed and quantitatively summarized the existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment, BMI cut points, references used in multivariate analysis, and ovarian cancer stage.

METHODS

Eligible studies were searched using MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials, relevant bibliographies were manually reviewed for additional studies. Adjusted hazard ratios (HRs) from individual studies were pooled using a random effects model.

RESULTS

17 cohort studies of 929 screened articles were included in the final analysis. Obesity in early adulthood and obesity 5 years before ovarian cancer diagnosis were associated with poor patient survival (early adulthood: pooled HR 1.67; 95% CI 1.29-2.16; 5 years prediagnosis: pooled HR 1.35; 95% CI 1.03-1.76). However, the results for obesity at diagnosis depended on whether BMI was analyzed as a categorical or continuous variable. Analysis of obesity with BMI as a categorical variable did not affect ovarian cancer prognosis (pooled HR 1.07; 95% CI 0.95-1.21); obesity with BMI as a continuous variable showed slightly poorer survival with each incremental increase in BMI (pooled HR 1.02; 95% CI 1.01-1.04).

CONCLUSIONS

Obesity 5 years before ovarian cancer diagnosis and obesity at a young age were associated with poor prognosis. The association between obesity at diagnosis and survival of ovarian cancer patients still remains equivocal. BMI at diagnosis cannot be a prognostic factor for the survival of ovarian cancer patients. Further well-designed studies are needed to elucidate the variety effect of obesity on the survival of ovarian cancer patients.

Authors+Show Affiliations

Departments of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.Departments of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.Departments of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.Departments of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.Departments of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24834130

Citation

Bae, Hyo Sook, et al. "Obesity and Epithelial Ovarian Cancer Survival: a Systematic Review and Meta-analysis." Journal of Ovarian Research, vol. 7, 2014, p. 41.
Bae HS, Kim HJ, Hong JH, et al. Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis. J Ovarian Res. 2014;7:41.
Bae, H. S., Kim, H. J., Hong, J. H., Lee, J. K., Lee, N. W., & Song, J. Y. (2014). Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis. Journal of Ovarian Research, 7, p. 41. doi:10.1186/1757-2215-7-41.
Bae HS, et al. Obesity and Epithelial Ovarian Cancer Survival: a Systematic Review and Meta-analysis. J Ovarian Res. 2014;7:41. PubMed PMID: 24834130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis. AU - Bae,Hyo Sook, AU - Kim,Hyun Jung, AU - Hong,Jin Hwa, AU - Lee,Jae Kwan, AU - Lee,Nak Woo, AU - Song,Jae Yun, Y1 - 2014/04/22/ PY - 2013/12/23/received PY - 2014/04/10/accepted PY - 2014/5/17/entrez PY - 2014/5/17/pubmed PY - 2014/5/17/medline KW - Body mass index KW - Obesity KW - Ovarian Neoplasms KW - Survival SP - 41 EP - 41 JF - Journal of ovarian research JO - J Ovarian Res VL - 7 N2 - BACKGROUND: Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed and quantitatively summarized the existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment, BMI cut points, references used in multivariate analysis, and ovarian cancer stage. METHODS: Eligible studies were searched using MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials, relevant bibliographies were manually reviewed for additional studies. Adjusted hazard ratios (HRs) from individual studies were pooled using a random effects model. RESULTS: 17 cohort studies of 929 screened articles were included in the final analysis. Obesity in early adulthood and obesity 5 years before ovarian cancer diagnosis were associated with poor patient survival (early adulthood: pooled HR 1.67; 95% CI 1.29-2.16; 5 years prediagnosis: pooled HR 1.35; 95% CI 1.03-1.76). However, the results for obesity at diagnosis depended on whether BMI was analyzed as a categorical or continuous variable. Analysis of obesity with BMI as a categorical variable did not affect ovarian cancer prognosis (pooled HR 1.07; 95% CI 0.95-1.21); obesity with BMI as a continuous variable showed slightly poorer survival with each incremental increase in BMI (pooled HR 1.02; 95% CI 1.01-1.04). CONCLUSIONS: Obesity 5 years before ovarian cancer diagnosis and obesity at a young age were associated with poor prognosis. The association between obesity at diagnosis and survival of ovarian cancer patients still remains equivocal. BMI at diagnosis cannot be a prognostic factor for the survival of ovarian cancer patients. Further well-designed studies are needed to elucidate the variety effect of obesity on the survival of ovarian cancer patients. SN - 1757-2215 UR - https://www.unboundmedicine.com/medline/citation/24834130/full_citation L2 - https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-7-41 DB - PRIME DP - Unbound Medicine ER -