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Adverse reactions to the sulphite additives.

Abstract

Sulphites are widely used as preservative and antioxidant additives in the food and pharmaceutical industries. Exposure to sulphites has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions. Exposure to the sulphites arises mainly from the consumption of foods and drinks that contain these additives; however exposure may also occur through the use of pharmaceutical products, as well as in occupational settings. Most studies report a prevalence of sulphite sensitivity of 3 to 10% among asthmatic subjects who ingest these additives. However, the severity of these reactions varies, and steroid-dependent asthmatics, those with marked airway hyperresponsiveness, and children with chronic asthma, appear to be at greater risk. Although a number of potential mechanisms have been proposed, the precise mechanisms underlying sulphite sensitivity remain unclear.

Authors+Show Affiliations

Senior Lecturer, School of Public Health and Human Biosciences, La Trobe University, Melbourne, VIC 3086, Australia ; Visiting Fellow, National Centre for Epidemiology and Population Health, ANU College of Medicine and Health Sciences, The Australian National University, Canberra ACT 0200, Australia.Adjunct Associate Professor, Lung Institute of Western Australia (Inc.), Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24834193

Citation

Vally, Hassan, and Neil LA Misso. "Adverse Reactions to the Sulphite Additives." Gastroenterology and Hepatology From Bed to Bench, vol. 5, no. 1, 2012, pp. 16-23.
Vally H, Misso NL. Adverse reactions to the sulphite additives. Gastroenterol Hepatol Bed Bench. 2012;5(1):16-23.
Vally, H., & Misso, N. L. (2012). Adverse reactions to the sulphite additives. Gastroenterology and Hepatology From Bed to Bench, 5(1), pp. 16-23.
Vally H, Misso NL. Adverse Reactions to the Sulphite Additives. Gastroenterol Hepatol Bed Bench. 2012;5(1):16-23. PubMed PMID: 24834193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse reactions to the sulphite additives. AU - Vally,Hassan, AU - Misso,Neil LA, PY - 2011/11/22/received PY - 2011/12/08/accepted PY - 2014/5/17/entrez PY - 2012/1/1/pubmed PY - 2012/1/1/medline KW - Asthma KW - Food additive KW - Sulphites SP - 16 EP - 23 JF - Gastroenterology and hepatology from bed to bench JO - Gastroenterol Hepatol Bed Bench VL - 5 IS - 1 N2 - Sulphites are widely used as preservative and antioxidant additives in the food and pharmaceutical industries. Exposure to sulphites has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions. Exposure to the sulphites arises mainly from the consumption of foods and drinks that contain these additives; however exposure may also occur through the use of pharmaceutical products, as well as in occupational settings. Most studies report a prevalence of sulphite sensitivity of 3 to 10% among asthmatic subjects who ingest these additives. However, the severity of these reactions varies, and steroid-dependent asthmatics, those with marked airway hyperresponsiveness, and children with chronic asthma, appear to be at greater risk. Although a number of potential mechanisms have been proposed, the precise mechanisms underlying sulphite sensitivity remain unclear. SN - 2008-2258 UR - https://www.unboundmedicine.com/medline/citation/24834193/Adverse_reactions_to_the_sulphite_additives_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24834193/ DB - PRIME DP - Unbound Medicine ER -