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Risk factors for carriage of AOM pathogens during the first 3 years of life in children with early onset of acute otitis media.
Acta Otolaryngol 2014; 134(7):684-90AO

Abstract

CONCLUSION

Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself.

OBJECTIVES

The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM.

METHODS

Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires.

RESULTS

A total of 109 children were included at a mean age of 5 months; 105 were followed for 3 years, 89 (82%) of whom developed rAOM. Risk factors associated with increased carriage of all major AOM pathogens were age <2 years, concurrent AOM, and fulfilment of rAOM criteria. Having siblings in day care was associated with increased carriage of Streptococcus pneumoniae and Haemophilus influenzae, recent antibiotic treatment was associated with H. influenzae and Moraxella catarrhalis carriage, and winter season was associated with M. catarrhalis carriage alone.

Authors+Show Affiliations

Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital , Lund.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24834935

Citation

Gisselsson-Solén, Marie, et al. "Risk Factors for Carriage of AOM Pathogens During the First 3 Years of Life in Children With Early Onset of Acute Otitis Media." Acta Oto-laryngologica, vol. 134, no. 7, 2014, pp. 684-90.
Gisselsson-Solén M, Henriksson G, Hermansson A, et al. Risk factors for carriage of AOM pathogens during the first 3 years of life in children with early onset of acute otitis media. Acta Otolaryngol. 2014;134(7):684-90.
Gisselsson-Solén, M., Henriksson, G., Hermansson, A., & Melhus, A. (2014). Risk factors for carriage of AOM pathogens during the first 3 years of life in children with early onset of acute otitis media. Acta Oto-laryngologica, 134(7), pp. 684-90. doi:10.3109/00016489.2014.890291.
Gisselsson-Solén M, et al. Risk Factors for Carriage of AOM Pathogens During the First 3 Years of Life in Children With Early Onset of Acute Otitis Media. Acta Otolaryngol. 2014;134(7):684-90. PubMed PMID: 24834935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for carriage of AOM pathogens during the first 3 years of life in children with early onset of acute otitis media. AU - Gisselsson-Solén,Marie, AU - Henriksson,Gunnel, AU - Hermansson,Ann, AU - Melhus,Asa, Y1 - 2014/05/19/ PY - 2014/5/20/entrez PY - 2014/5/20/pubmed PY - 2015/2/11/medline KW - Haemophilus influenzae KW - Moraxella catarrhalis KW - Otitis-prone children KW - Streptococcus pneumoniae KW - day care KW - nasopharyngeal carriage KW - nasopharyngeal colonization KW - rAOM KW - season SP - 684 EP - 90 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 134 IS - 7 N2 - CONCLUSION: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. OBJECTIVES: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. METHODS: Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires. RESULTS: A total of 109 children were included at a mean age of 5 months; 105 were followed for 3 years, 89 (82%) of whom developed rAOM. Risk factors associated with increased carriage of all major AOM pathogens were age <2 years, concurrent AOM, and fulfilment of rAOM criteria. Having siblings in day care was associated with increased carriage of Streptococcus pneumoniae and Haemophilus influenzae, recent antibiotic treatment was associated with H. influenzae and Moraxella catarrhalis carriage, and winter season was associated with M. catarrhalis carriage alone. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/24834935/Risk_factors_for_carriage_of_AOM_pathogens_during_the_first_3_years_of_life_in_children_with_early_onset_of_acute_otitis_media_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489.2014.890291 DB - PRIME DP - Unbound Medicine ER -