Tags

Type your tag names separated by a space and hit enter

Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms.
J Diabetes Complications. 2014 Nov-Dec; 28(6):836-43.JD

Abstract

AIMS

Recent studies suggest that circadian rhythms regulate glucose metabolism, weight loss, and even drug efficacy. Moreover, molecules targeted at the circadian clock show promise in treating metabolic disease. Therefore, this study set out to better characterize interactions among diurnal rhythms in prediabetes.

METHODS

Ten subjects with prediabetes completed oral glucose tolerance tests at 0700h and 1900h on the same day. Lipids and hormones were also measured.

RESULTS

Two-hour and three-hour glucose tolerances were worse in the evening by 40±52mg/dl (p=0.02) and 62±46mg/dl (p=0.001), respectively. These impairments were explained by lower insulin sensitivity (OGIS; 5.14±1.02 vs. 4.74±0.77mg/kg/min; p=0.03) and 2-hour AUC insulin levels (87.4±37.6 vs. 69.8±40.2mU∙hr/l; p=0.02) in the evening. Intriguingly, more insulin resistant subjects had weaker rhythms in insulin sensitivity (r=-0.66; p=0.04) but enhanced rhythms in insulin (r=-0.67; p=0.03) and cortisol (r=-0.78; p=0.008) levels. Importantly, the rhythms in cortisol primarily but also insulin sensitivity drove the declines in evening glucose tolerance (r=0.86; p=0.002).

CONCLUSIONS

Glycemic control is dramatically impaired in the evening in people with prediabetes, particularly when the cortisol rhythm is weak, but is unrelated to the rhythm in insulin levels. Therefore, food intake at dinnertime may need to be curbed in prediabetes.

Authors+Show Affiliations

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA; Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA; LaCell LLC, New Orleans, LA 70112, USA.Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address: courtney.peterson@pbrc.edu.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24835190

Citation

Sonnier, Tance, et al. "Glycemic Control Is Impaired in the Evening in Prediabetes Through Multiple Diurnal Rhythms." Journal of Diabetes and Its Complications, vol. 28, no. 6, 2014, pp. 836-43.
Sonnier T, Rood J, Gimble JM, et al. Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms. J Diabetes Complicat. 2014;28(6):836-43.
Sonnier, T., Rood, J., Gimble, J. M., & Peterson, C. M. (2014). Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms. Journal of Diabetes and Its Complications, 28(6), 836-43. https://doi.org/10.1016/j.jdiacomp.2014.04.001
Sonnier T, et al. Glycemic Control Is Impaired in the Evening in Prediabetes Through Multiple Diurnal Rhythms. J Diabetes Complicat. 2014 Nov-Dec;28(6):836-43. PubMed PMID: 24835190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms. AU - Sonnier,Tance, AU - Rood,Jennifer, AU - Gimble,Jeffrey M, AU - Peterson,Courtney M, Y1 - 2014/04/12/ PY - 2013/12/04/received PY - 2014/03/11/revised PY - 2014/04/01/accepted PY - 2014/5/20/entrez PY - 2014/5/20/pubmed PY - 2015/8/25/medline KW - Circadian rhythms KW - Cortisol KW - Diurnal rhythm KW - Glucose tolerance KW - Oral Glucose Tolerance Test (OGTT) KW - Prediabetes SP - 836 EP - 43 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 28 IS - 6 N2 - AIMS: Recent studies suggest that circadian rhythms regulate glucose metabolism, weight loss, and even drug efficacy. Moreover, molecules targeted at the circadian clock show promise in treating metabolic disease. Therefore, this study set out to better characterize interactions among diurnal rhythms in prediabetes. METHODS: Ten subjects with prediabetes completed oral glucose tolerance tests at 0700h and 1900h on the same day. Lipids and hormones were also measured. RESULTS: Two-hour and three-hour glucose tolerances were worse in the evening by 40±52mg/dl (p=0.02) and 62±46mg/dl (p=0.001), respectively. These impairments were explained by lower insulin sensitivity (OGIS; 5.14±1.02 vs. 4.74±0.77mg/kg/min; p=0.03) and 2-hour AUC insulin levels (87.4±37.6 vs. 69.8±40.2mU∙hr/l; p=0.02) in the evening. Intriguingly, more insulin resistant subjects had weaker rhythms in insulin sensitivity (r=-0.66; p=0.04) but enhanced rhythms in insulin (r=-0.67; p=0.03) and cortisol (r=-0.78; p=0.008) levels. Importantly, the rhythms in cortisol primarily but also insulin sensitivity drove the declines in evening glucose tolerance (r=0.86; p=0.002). CONCLUSIONS: Glycemic control is dramatically impaired in the evening in people with prediabetes, particularly when the cortisol rhythm is weak, but is unrelated to the rhythm in insulin levels. Therefore, food intake at dinnertime may need to be curbed in prediabetes. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/24835190/Glycemic_control_is_impaired_in_the_evening_in_prediabetes_through_multiple_diurnal_rhythms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(14)00090-7 DB - PRIME DP - Unbound Medicine ER -