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Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).
Environ Health Perspect. 2014 Sep; 122(9):896-905.EH

Abstract

BACKGROUND

Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific.

OBJECTIVES

We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations.

METHODS

We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis.

RESULTS

In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated.

CONCLUSIONS

In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.

Authors+Show Affiliations

IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24835507

Citation

Fuks, Kateryna B., et al. "Arterial Blood Pressure and Long-term Exposure to Traffic-related Air Pollution: an Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)." Environmental Health Perspectives, vol. 122, no. 9, 2014, pp. 896-905.
Fuks KB, Weinmayr G, Foraster M, et al. Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect. 2014;122(9):896-905.
Fuks, K. B., Weinmayr, G., Foraster, M., Dratva, J., Hampel, R., Houthuijs, D., Oftedal, B., Oudin, A., Panasevich, S., Penell, J., Sommar, J. N., Sørensen, M., Tiittanen, P., Wolf, K., Xun, W. W., Aguilera, I., Basagaña, X., Beelen, R., Bots, M. L., ... Hoffmann, B. (2014). Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environmental Health Perspectives, 122(9), 896-905. https://doi.org/10.1289/ehp.1307725
Fuks KB, et al. Arterial Blood Pressure and Long-term Exposure to Traffic-related Air Pollution: an Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect. 2014;122(9):896-905. PubMed PMID: 24835507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). AU - Fuks,Kateryna B, AU - Weinmayr,Gudrun, AU - Foraster,Maria, AU - Dratva,Julia, AU - Hampel,Regina, AU - Houthuijs,Danny, AU - Oftedal,Bente, AU - Oudin,Anna, AU - Panasevich,Sviatlana, AU - Penell,Johanna, AU - Sommar,Johan N, AU - Sørensen,Mette, AU - Tiittanen,Pekka, AU - Wolf,Kathrin, AU - Xun,Wei W, AU - Aguilera,Inmaculada, AU - Basagaña,Xavier, AU - Beelen,Rob, AU - Bots,Michiel L, AU - Brunekreef,Bert, AU - Bueno-de-Mesquita,H Bas, AU - Caracciolo,Barbara, AU - Cirach,Marta, AU - de Faire,Ulf, AU - de Nazelle,Audrey, AU - Eeftens,Marloes, AU - Elosua,Roberto, AU - Erbel,Raimund, AU - Forsberg,Bertil, AU - Fratiglioni,Laura, AU - Gaspoz,Jean-Michel, AU - Hilding,Agneta, AU - Jula,Antti, AU - Korek,Michal, AU - Krämer,Ursula, AU - Künzli,Nino, AU - Lanki,Timo, AU - Leander,Karin, AU - Magnusson,Patrik K E, AU - Marrugat,Jaume, AU - Nieuwenhuijsen,Mark J, AU - Ostenson,Claes-Göran, AU - Pedersen,Nancy L, AU - Pershagen,Göran, AU - Phuleria,Harish C, AU - Probst-Hensch,Nicole M, AU - Raaschou-Nielsen,Ole, AU - Schaffner,Emmanuel, AU - Schikowski,Tamara, AU - Schindler,Christian, AU - Schwarze,Per E, AU - Søgaard,Anne J, AU - Sugiri,Dorothea, AU - Swart,Wim J R, AU - Tsai,Ming-Yi, AU - Turunen,Anu W, AU - Vineis,Paolo, AU - Peters,Annette, AU - Hoffmann,Barbara, Y1 - 2014/05/16/ PY - 2013/10/01/received PY - 2014/05/15/accepted PY - 2014/5/20/entrez PY - 2014/5/20/pubmed PY - 2016/4/26/medline SP - 896 EP - 905 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 122 IS - 9 N2 - BACKGROUND: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. OBJECTIVES: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. METHODS: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. RESULTS: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated. CONCLUSIONS: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/24835507/Arterial_blood_pressure_and_long_term_exposure_to_traffic_related_air_pollution:_an_analysis_in_the_European_Study_of_Cohorts_for_Air_Pollution_Effects__ESCAPE__ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.1307725?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -