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Are ICAM, VCAM and E-selectin levels different in first manic episode and subsequent remission?
J Affect Disord. 2014 Jul; 163:76-80.JA

Abstract

OBJECTIVE

In bipolar patients, the rate of mortality from cardiovascular diseases is two-fold higher than that in other psychiatric disorders. The risk of cardiovascular diseases was found to be associated with some cellular adhesion molecules: Intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and E-selectin. The aim of this study was to compare ICAM, VCAM and E-selectin levels at first manic episode and subsequent remission period, and to investigate the presence of a relationship between adhesion molecules levels and clinical and metabolic variables.

METHODS

In line with this purpose, 50 patients diagnosed with mania according to DSM IV-TR criteria, who had their first episode were evaluated consecutively. The control group consisted of 50 healthy individuals without any history of psychiatric admission and treatment, matched with the manic patients in terms of age, gender, BMI and smoking status. For the confirmation of subsequent remission period (n=40), Young Mania Rating Scale and Hamilton Depression Rating Scale were used. In three groups plasma ICAM, VCAM and E-selectin, fasting blood glucose, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels were measured and compared.

RESULTS

ICAM and VCAM levels were found to be higher in first manic episode than those in subsequent remission and healthy individuals. A weak correlation was found between ICAM levels and YMRS scores in manic patients. In first manic episode, a weak correlation was found between ICAM and total cholesterol and LDL cholesterol levels and a weak correlation was found between ICAM, VCAM and E-selectin levels and BMI.

CONCLUSION

In the present study, which is the first investigation of proinflammatory and prothrombotic state, which is defined as a risk for metabolic syndrome and cardiovascular disease, in bipolar disorder, ICAM and VCAM levels were found to be higher in first episode mania than those in subsequent remission and healthy individuals. As the study group included first episode mani cases, there was no effect of chronic psychotropic use. Probable risk of cardiovascular disease, reflected by increased ICAM and VCAM levels is already present in bipolar patients at the onset of the disease. In addition, ICAM and VCAM levels increasing in manic episode, return to normal in the subsequent remission period.

Authors+Show Affiliations

Erenköy Mental and Neurological Disease Training and Research Hospital, Sinan Ercan C. N: 29 Kadıköy, İstanbul, Turkey.Erenköy Mental and Neurological Disease Training and Research Hospital, Sinan Ercan C. N: 29 Kadıköy, İstanbul, Turkey. Electronic address: serminkesebir@hotmail.com.Erenköy Mental and Neurological Disease Training and Research Hospital, Sinan Ercan C. N: 29 Kadıköy, İstanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24836091

Citation

Turan, Cetin, et al. "Are ICAM, VCAM and E-selectin Levels Different in First Manic Episode and Subsequent Remission?" Journal of Affective Disorders, vol. 163, 2014, pp. 76-80.
Turan C, Kesebir S, Süner O. Are ICAM, VCAM and E-selectin levels different in first manic episode and subsequent remission? J Affect Disord. 2014;163:76-80.
Turan, C., Kesebir, S., & Süner, O. (2014). Are ICAM, VCAM and E-selectin levels different in first manic episode and subsequent remission? Journal of Affective Disorders, 163, 76-80. https://doi.org/10.1016/j.jad.2014.03.052
Turan C, Kesebir S, Süner O. Are ICAM, VCAM and E-selectin Levels Different in First Manic Episode and Subsequent Remission. J Affect Disord. 2014;163:76-80. PubMed PMID: 24836091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are ICAM, VCAM and E-selectin levels different in first manic episode and subsequent remission? AU - Turan,Cetin, AU - Kesebir,Sermin, AU - Süner,Ozgür, Y1 - 2014/04/12/ PY - 2013/12/26/received PY - 2014/03/27/revised PY - 2014/03/29/accepted PY - 2014/5/20/entrez PY - 2014/5/20/pubmed PY - 2014/10/15/medline KW - Atherosclerosis KW - Bipolar disorder KW - E-selectin KW - ICAM KW - VCAM SP - 76 EP - 80 JF - Journal of affective disorders JO - J Affect Disord VL - 163 N2 - OBJECTIVE: In bipolar patients, the rate of mortality from cardiovascular diseases is two-fold higher than that in other psychiatric disorders. The risk of cardiovascular diseases was found to be associated with some cellular adhesion molecules: Intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and E-selectin. The aim of this study was to compare ICAM, VCAM and E-selectin levels at first manic episode and subsequent remission period, and to investigate the presence of a relationship between adhesion molecules levels and clinical and metabolic variables. METHODS: In line with this purpose, 50 patients diagnosed with mania according to DSM IV-TR criteria, who had their first episode were evaluated consecutively. The control group consisted of 50 healthy individuals without any history of psychiatric admission and treatment, matched with the manic patients in terms of age, gender, BMI and smoking status. For the confirmation of subsequent remission period (n=40), Young Mania Rating Scale and Hamilton Depression Rating Scale were used. In three groups plasma ICAM, VCAM and E-selectin, fasting blood glucose, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels were measured and compared. RESULTS: ICAM and VCAM levels were found to be higher in first manic episode than those in subsequent remission and healthy individuals. A weak correlation was found between ICAM levels and YMRS scores in manic patients. In first manic episode, a weak correlation was found between ICAM and total cholesterol and LDL cholesterol levels and a weak correlation was found between ICAM, VCAM and E-selectin levels and BMI. CONCLUSION: In the present study, which is the first investigation of proinflammatory and prothrombotic state, which is defined as a risk for metabolic syndrome and cardiovascular disease, in bipolar disorder, ICAM and VCAM levels were found to be higher in first episode mania than those in subsequent remission and healthy individuals. As the study group included first episode mani cases, there was no effect of chronic psychotropic use. Probable risk of cardiovascular disease, reflected by increased ICAM and VCAM levels is already present in bipolar patients at the onset of the disease. In addition, ICAM and VCAM levels increasing in manic episode, return to normal in the subsequent remission period. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/24836091/Are_ICAM_VCAM_and_E_selectin_levels_different_in_first_manic_episode_and_subsequent_remission L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(14)00172-4 DB - PRIME DP - Unbound Medicine ER -