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Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release.

Abstract

The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N'-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.

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  • Authors+Show Affiliations

    ,

    IMBIV-CONICET, Departamento de Química Orgánica, ‡UNITEFA-CONICET, Departamento de Farmacia, §CIBICI-CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Haya de la Torre y Medina Allende, Edificio de Ciencias II, Ciudad Universitaria, Córdoba X5000HUA, Argentina.

    , , ,

    Source

    Molecular pharmaceutics 11:7 2014 Jul 7 pg 2239-49

    MeSH

    Acrylamides
    Acrylates
    Acrylic Resins
    Delayed-Action Preparations
    Hydrogels
    Hydrogen-Ion Concentration
    Ofloxacin
    Polymers
    Solvents
    Temperature
    Water

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24836377

    Citation

    TY - JOUR T1 - Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release. AU - Cuggino,Julio César, AU - Contreras,Cintia Belén, AU - Jimenez-Kairuz,Alvaro, AU - Maletto,Belkys Angélica, AU - Alvarez Igarzabal,Cecilia Inés, Y1 - 2014/05/27/ PY - 2014/5/27/aheadofprint PY - 2014/5/20/entrez PY - 2014/5/20/pubmed PY - 2016/5/5/medline SP - 2239 EP - 49 JF - Molecular pharmaceutics JO - Mol. Pharm. VL - 11 IS - 7 N2 - The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N'-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media. SN - 1543-8392 UR - https://www.unboundmedicine.com/medline/citation/24836377/Novel_poly_NIPA_co_AAc__functional_hydrogels_with_potential_application_in_drug_controlled_release_ L2 - http://dx.doi.org/10.1021/mp400615n ER -