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Analysis of HLA B27 in ankylosing spondylitis with human alloreactive cytolytic T lymphocyte clones: failure to detect disease-related T cell epitopes.
Exp Clin Immunogenet. 1986; 3(3):129-37.EC

Abstract

We have generated several human alloreactive cytolytic T lymphocyte (CTL) clones specific for HLA B27 expressed on cells of normals or of patients with ankylosing spondylitis (AS). These clonal T cell reagents were used to test the recognition of panels of target cells from B27+AS+, B27+AS- and B27- individuals. None of these CTL clones distinguished differences between B27+AS+ and B27+AS- cells. Three clones recognized subtypes of HLA B27 and two of these were cytolytic with group-reactive epitopes of other HLA antigens. The results suggest that there are no immunogenic disease-specific epitopes of HLA B27 in B27-linked spondyloarthropathy.

Authors+Show Affiliations

Czitrom AA
Department of Surgery, University of Toronoto, Ont., Canada.
Pototschnik R
No affiliation info available
Edwards S
No affiliation info available
Gladman DD
No affiliation info available
Falk JA
No affiliation info available

MeSH

Clone CellsEpitopesHLA-B27 AntigenHumansLymphocyte Culture Test, MixedSpondylitis, AnkylosingT-Lymphocytes, Cytotoxic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2484102

Citation

Czitrom, A A., et al. "Analysis of HLA B27 in Ankylosing Spondylitis With Human Alloreactive Cytolytic T Lymphocyte Clones: Failure to Detect Disease-related T Cell Epitopes." Experimental and Clinical Immunogenetics, vol. 3, no. 3, 1986, pp. 129-37.
Czitrom AA, Pototschnik R, Edwards S, et al. Analysis of HLA B27 in ankylosing spondylitis with human alloreactive cytolytic T lymphocyte clones: failure to detect disease-related T cell epitopes. Exp Clin Immunogenet. 1986;3(3):129-37.
Czitrom, A. A., Pototschnik, R., Edwards, S., Gladman, D. D., & Falk, J. A. (1986). Analysis of HLA B27 in ankylosing spondylitis with human alloreactive cytolytic T lymphocyte clones: failure to detect disease-related T cell epitopes. Experimental and Clinical Immunogenetics, 3(3), 129-37.
Czitrom AA, et al. Analysis of HLA B27 in Ankylosing Spondylitis With Human Alloreactive Cytolytic T Lymphocyte Clones: Failure to Detect Disease-related T Cell Epitopes. Exp Clin Immunogenet. 1986;3(3):129-37. PubMed PMID: 2484102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of HLA B27 in ankylosing spondylitis with human alloreactive cytolytic T lymphocyte clones: failure to detect disease-related T cell epitopes. AU - Czitrom,A A, AU - Pototschnik,R, AU - Edwards,S, AU - Gladman,D D, AU - Falk,J A, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 129 EP - 37 JF - Experimental and clinical immunogenetics JO - Exp Clin Immunogenet VL - 3 IS - 3 N2 - We have generated several human alloreactive cytolytic T lymphocyte (CTL) clones specific for HLA B27 expressed on cells of normals or of patients with ankylosing spondylitis (AS). These clonal T cell reagents were used to test the recognition of panels of target cells from B27+AS+, B27+AS- and B27- individuals. None of these CTL clones distinguished differences between B27+AS+ and B27+AS- cells. Three clones recognized subtypes of HLA B27 and two of these were cytolytic with group-reactive epitopes of other HLA antigens. The results suggest that there are no immunogenic disease-specific epitopes of HLA B27 in B27-linked spondyloarthropathy. SN - 0254-9670 UR - https://www.unboundmedicine.com/medline/citation/2484102/Analysis_of_HLA_B27_in_ankylosing_spondylitis_with_human_alloreactive_cytolytic_T_lymphocyte_clones:_failure_to_detect_disease_related_T_cell_epitopes_ DB - PRIME DP - Unbound Medicine ER -