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Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch.
Pharm Dev Technol. 2015; 20(6):747-54.PD

Abstract

The objective of this study was to investigate the effects of conventional lubricants including a new candidate lubricant "hexagonal boron nitride (HBN)" on direct compression powders. Lubricants such as magnesium stearate (MGST), glyceryl behenate, stearic acid, talc and polyethylene glycol6000 were studied and tablets were manufactured on a single station instrumented tablet press. This study comprised the continuation of our previous one, so mixture of microcrystalline cellulose and modified starch was used as a master formula to evaluate effects of lubricants on pharmaceutical excipients that undergo complete plastic deformation without any fragmentation under compression pressure. Bulk and tapped densities, and Carr's index parameters were calculated for powders. Tensile strength, cohesion index, lower punch ejection force and lubricant effectiveness values were investigated for tablets. The deformation mechanisms of tablets were studied during compression from the Heckel plots with or without lubricant. MGST was found to be the most effective lubricant and HBN was found very close to it. HBN did not show a significant negative effect on the crushing strength and disintegration time of the tablets when we compared with MGST. Based on the Heckel plots at the level of 1%, formulation prepared with HBN showed the most pronounced plastic character.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Halaçoğlu MD
Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University , Haydarpasa, Istanbul , Turkey.
Uğurlu T
No affiliation info available

MeSH

Boron CompoundsCelluloseExcipientsHardnessLubricantsPowdersSolubilityStarchTabletsTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24841191

Citation

Halaçoğlu, Mekin Doğa, and Timuçin Uğurlu. "Compression Parameters of Hexagonal Boron Nitride On Direct Compression Mixture of Microcrystalline Cellulose and Modified Starch." Pharmaceutical Development and Technology, vol. 20, no. 6, 2015, pp. 747-54.
Halaçoğlu MD, Uğurlu T. Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch. Pharm Dev Technol. 2015;20(6):747-54.
Halaçoğlu, M. D., & Uğurlu, T. (2015). Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch. Pharmaceutical Development and Technology, 20(6), 747-54. https://doi.org/10.3109/10837450.2014.920354
Halaçoğlu MD, Uğurlu T. Compression Parameters of Hexagonal Boron Nitride On Direct Compression Mixture of Microcrystalline Cellulose and Modified Starch. Pharm Dev Technol. 2015;20(6):747-54. PubMed PMID: 24841191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch. AU - Halaçoğlu,Mekin Doğa, AU - Uğurlu,Timuçin, Y1 - 2014/05/20/ PY - 2014/5/21/entrez PY - 2014/5/21/pubmed PY - 2016/5/12/medline KW - Cohesion index KW - direct compression KW - hexagonal boron nitride KW - lubricant effectiveness KW - lubricants SP - 747 EP - 54 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 20 IS - 6 N2 - The objective of this study was to investigate the effects of conventional lubricants including a new candidate lubricant "hexagonal boron nitride (HBN)" on direct compression powders. Lubricants such as magnesium stearate (MGST), glyceryl behenate, stearic acid, talc and polyethylene glycol6000 were studied and tablets were manufactured on a single station instrumented tablet press. This study comprised the continuation of our previous one, so mixture of microcrystalline cellulose and modified starch was used as a master formula to evaluate effects of lubricants on pharmaceutical excipients that undergo complete plastic deformation without any fragmentation under compression pressure. Bulk and tapped densities, and Carr's index parameters were calculated for powders. Tensile strength, cohesion index, lower punch ejection force and lubricant effectiveness values were investigated for tablets. The deformation mechanisms of tablets were studied during compression from the Heckel plots with or without lubricant. MGST was found to be the most effective lubricant and HBN was found very close to it. HBN did not show a significant negative effect on the crushing strength and disintegration time of the tablets when we compared with MGST. Based on the Heckel plots at the level of 1%, formulation prepared with HBN showed the most pronounced plastic character. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/24841191/Compression_parameters_of_hexagonal_boron_nitride_on_direct_compression_mixture_of_microcrystalline_cellulose_and_modified_starch_ DB - PRIME DP - Unbound Medicine ER -