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Vitamin supplementation in the treatment of schizophrenia.

Abstract

This article reviews the current literature addressing the treatment of schizophrenia with vitamin supplementation. It describes the important roles that vitamins play in normal metabolism, and reviews the evidence pertaining to vitamin deficiency and supplementation in patients with schizophrenia. There is mounting evidence suggesting that vitamin supplementation, in particular with folic acid, vitamin B12 and vitamin D, may be important in treatment within certain subgroups of patients. There is a need for larger randomized controlled trials, and further studies examining the incidence of schizophrenia in countries with poor prenatal care and malnutrition, as well as in countries that have adopted mandatory folic acid fortification of grain products, are recommended.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA, hebrown@partners.org.

    Source

    CNS drugs 28:7 2014 Jul pg 611-22

    MeSH

    Avitaminosis
    Dietary Supplements
    Folic Acid
    Humans
    Schizophrenia
    Vitamin B 12
    Vitamin D
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    24846474

    Citation

    Brown, Hannah E., and Joshua L. Roffman. "Vitamin Supplementation in the Treatment of Schizophrenia." CNS Drugs, vol. 28, no. 7, 2014, pp. 611-22.
    Brown HE, Roffman JL. Vitamin supplementation in the treatment of schizophrenia. CNS Drugs. 2014;28(7):611-22.
    Brown, H. E., & Roffman, J. L. (2014). Vitamin supplementation in the treatment of schizophrenia. CNS Drugs, 28(7), pp. 611-22. doi:10.1007/s40263-014-0172-4.
    Brown HE, Roffman JL. Vitamin Supplementation in the Treatment of Schizophrenia. CNS Drugs. 2014;28(7):611-22. PubMed PMID: 24846474.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin supplementation in the treatment of schizophrenia. AU - Brown,Hannah E, AU - Roffman,Joshua L, PY - 2014/5/22/entrez PY - 2014/5/23/pubmed PY - 2015/2/24/medline SP - 611 EP - 22 JF - CNS drugs JO - CNS Drugs VL - 28 IS - 7 N2 - This article reviews the current literature addressing the treatment of schizophrenia with vitamin supplementation. It describes the important roles that vitamins play in normal metabolism, and reviews the evidence pertaining to vitamin deficiency and supplementation in patients with schizophrenia. There is mounting evidence suggesting that vitamin supplementation, in particular with folic acid, vitamin B12 and vitamin D, may be important in treatment within certain subgroups of patients. There is a need for larger randomized controlled trials, and further studies examining the incidence of schizophrenia in countries with poor prenatal care and malnutrition, as well as in countries that have adopted mandatory folic acid fortification of grain products, are recommended. SN - 1179-1934 UR - https://www.unboundmedicine.com/medline/citation/24846474/full_citation L2 - https://dx.doi.org/10.1007/s40263-014-0172-4 DB - PRIME DP - Unbound Medicine ER -