Tags

Type your tag names separated by a space and hit enter

Vitamin D status and Parkinson's disease: a systematic review and meta-analysis.
Neurol Sci. 2014 Nov; 35(11):1723-30.NS

Abstract

To estimate the associations between vitamin D status and Parkinson's disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'Parkinson's disease'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included. Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), -16.9, 95 % confidence interval (CI)], -33.5 to -0.2). Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1-2.0). Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5-3.4). Low vitamin D levels are associated with an increased risk of PD.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Lv Z
Department of Rehabilitation, the First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Qi H
No affiliation info available
Wang L
No affiliation info available
Fan X
No affiliation info available
Han F
No affiliation info available
Wang H
No affiliation info available
Bi S
No affiliation info available

MeSH

HumansParkinson DiseaseRisk FactorsVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24847960

Citation

Lv, Zheng, et al. "Vitamin D Status and Parkinson's Disease: a Systematic Review and Meta-analysis." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 35, no. 11, 2014, pp. 1723-30.
Lv Z, Qi H, Wang L, et al. Vitamin D status and Parkinson's disease: a systematic review and meta-analysis. Neurol Sci. 2014;35(11):1723-30.
Lv, Z., Qi, H., Wang, L., Fan, X., Han, F., Wang, H., & Bi, S. (2014). Vitamin D status and Parkinson's disease: a systematic review and meta-analysis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 35(11), 1723-30. https://doi.org/10.1007/s10072-014-1821-6
Lv Z, et al. Vitamin D Status and Parkinson's Disease: a Systematic Review and Meta-analysis. Neurol Sci. 2014;35(11):1723-30. PubMed PMID: 24847960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and Parkinson's disease: a systematic review and meta-analysis. AU - Lv,Zheng, AU - Qi,Huiping, AU - Wang,Le, AU - Fan,Xiaoxue, AU - Han,Fei, AU - Wang,Hong, AU - Bi,Sheng, Y1 - 2014/05/22/ PY - 2014/03/03/received PY - 2014/05/03/accepted PY - 2014/5/23/entrez PY - 2014/5/23/pubmed PY - 2015/11/11/medline SP - 1723 EP - 30 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 35 IS - 11 N2 - To estimate the associations between vitamin D status and Parkinson's disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'Parkinson's disease'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included. Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), -16.9, 95 % confidence interval (CI)], -33.5 to -0.2). Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1-2.0). Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5-3.4). Low vitamin D levels are associated with an increased risk of PD. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/24847960/full_citation DB - PRIME DP - Unbound Medicine ER -