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Vitamin D status and Parkinson's disease: a systematic review and meta-analysis.
Neurol Sci 2014; 35(11):1723-30NS

Abstract

To estimate the associations between vitamin D status and Parkinson's disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'Parkinson's disease'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included. Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), -16.9, 95 % confidence interval (CI)], -33.5 to -0.2). Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1-2.0). Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5-3.4). Low vitamin D levels are associated with an increased risk of PD.

Authors+Show Affiliations

Department of Rehabilitation, the First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24847960

Citation

Lv, Zheng, et al. "Vitamin D Status and Parkinson's Disease: a Systematic Review and Meta-analysis." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 35, no. 11, 2014, pp. 1723-30.
Lv Z, Qi H, Wang L, et al. Vitamin D status and Parkinson's disease: a systematic review and meta-analysis. Neurol Sci. 2014;35(11):1723-30.
Lv, Z., Qi, H., Wang, L., Fan, X., Han, F., Wang, H., & Bi, S. (2014). Vitamin D status and Parkinson's disease: a systematic review and meta-analysis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 35(11), pp. 1723-30. doi:10.1007/s10072-014-1821-6.
Lv Z, et al. Vitamin D Status and Parkinson's Disease: a Systematic Review and Meta-analysis. Neurol Sci. 2014;35(11):1723-30. PubMed PMID: 24847960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and Parkinson's disease: a systematic review and meta-analysis. AU - Lv,Zheng, AU - Qi,Huiping, AU - Wang,Le, AU - Fan,Xiaoxue, AU - Han,Fei, AU - Wang,Hong, AU - Bi,Sheng, Y1 - 2014/05/22/ PY - 2014/03/03/received PY - 2014/05/03/accepted PY - 2014/5/23/entrez PY - 2014/5/23/pubmed PY - 2015/11/11/medline SP - 1723 EP - 30 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 35 IS - 11 N2 - To estimate the associations between vitamin D status and Parkinson's disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'Parkinson's disease'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included. Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), -16.9, 95 % confidence interval (CI)], -33.5 to -0.2). Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1-2.0). Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5-3.4). Low vitamin D levels are associated with an increased risk of PD. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/24847960/full_citation L2 - https://dx.doi.org/10.1007/s10072-014-1821-6 DB - PRIME DP - Unbound Medicine ER -