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Unnatural deaths in a national cohort of people diagnosed with diabetes.
Diabetes Care. 2014 Aug; 37(8):2276-83.DC

Abstract

OBJECTIVE

To examine risk of unnatural death among people diagnosed with diabetes irrespective of disease type.

RESEARCH DESIGN AND METHODS

We conducted a matched cohort study of the entire Swedish population using interlinked national registers. From the National Diabetes Register we identified 252,191 people diagnosed with diabetes (type 1 or 2) during 1996-2009. Each cohort member was matched for age, sex, and county of birth to five unaffected individuals randomly sampled from the Total Population Register. Mortality was examined with complete ascertainment, and risk ratios (RRs) for all unnatural deaths and for specific causes (suicide, accident, homicide, and iatrogenic effects) were estimated using conditional fixed-effects Poisson regression.

RESULTS

Risk of any unnatural death was elevated versus the general population: 77.3 versus 32.1 per 10,000 (RR 2.2 [95% CI 2.1-2.4]), and these deaths occurred at a younger age in the diabetes cohort. Risk was increased for suicide (RR 3.4 [95% CI 3.0-3.8]), accident (RR 2.0 [95% CI 1.9-2.1]), homicide (RR 3.1 [95% CI 1.6-6.1]), and iatrogenic effects (RR 2.4 [95% CI 1.9-3.2]). It was greatly elevated for fatal poisoning from a variety of agents, including psychotropic drugs and "other and unspecified medication," as well as narcotics, alcohol, and carbon monoxide. Almost 9% of all fatal poisoning cases in the diabetes cohort were identified as overdoses of insulin or oral hypoglycemic drugs.

CONCLUSIONS

Various causes of unnatural death, in particular deliberate and accidental poisonings, occur more frequently among diabetic patients. Before preventive strategies can be implemented, a deeper understanding of the risk factors and causal mechanisms explaining the marked elevations in risk is needed.

Authors+Show Affiliations

Centre for Mental Health and Risk, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, U.K. roger.webb@manchester.ac.uk.Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden.Centre for Mental Health and Risk, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, U.K.Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Pediatrics, Örebro University Hospital, Örebro, Sweden.Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24848285

Citation

Webb, Roger T., et al. "Unnatural Deaths in a National Cohort of People Diagnosed With Diabetes." Diabetes Care, vol. 37, no. 8, 2014, pp. 2276-83.
Webb RT, Lichtenstein P, Dahlin M, et al. Unnatural deaths in a national cohort of people diagnosed with diabetes. Diabetes Care. 2014;37(8):2276-83.
Webb, R. T., Lichtenstein, P., Dahlin, M., Kapur, N., Ludvigsson, J. F., & Runeson, B. (2014). Unnatural deaths in a national cohort of people diagnosed with diabetes. Diabetes Care, 37(8), 2276-83. https://doi.org/10.2337/dc14-0005
Webb RT, et al. Unnatural Deaths in a National Cohort of People Diagnosed With Diabetes. Diabetes Care. 2014;37(8):2276-83. PubMed PMID: 24848285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unnatural deaths in a national cohort of people diagnosed with diabetes. AU - Webb,Roger T, AU - Lichtenstein,Paul, AU - Dahlin,Marie, AU - Kapur,Navneet, AU - Ludvigsson,Jonas F, AU - Runeson,Bo, Y1 - 2014/05/21/ PY - 2014/5/23/entrez PY - 2014/5/23/pubmed PY - 2015/10/2/medline SP - 2276 EP - 83 JF - Diabetes care JO - Diabetes Care VL - 37 IS - 8 N2 - OBJECTIVE: To examine risk of unnatural death among people diagnosed with diabetes irrespective of disease type. RESEARCH DESIGN AND METHODS: We conducted a matched cohort study of the entire Swedish population using interlinked national registers. From the National Diabetes Register we identified 252,191 people diagnosed with diabetes (type 1 or 2) during 1996-2009. Each cohort member was matched for age, sex, and county of birth to five unaffected individuals randomly sampled from the Total Population Register. Mortality was examined with complete ascertainment, and risk ratios (RRs) for all unnatural deaths and for specific causes (suicide, accident, homicide, and iatrogenic effects) were estimated using conditional fixed-effects Poisson regression. RESULTS: Risk of any unnatural death was elevated versus the general population: 77.3 versus 32.1 per 10,000 (RR 2.2 [95% CI 2.1-2.4]), and these deaths occurred at a younger age in the diabetes cohort. Risk was increased for suicide (RR 3.4 [95% CI 3.0-3.8]), accident (RR 2.0 [95% CI 1.9-2.1]), homicide (RR 3.1 [95% CI 1.6-6.1]), and iatrogenic effects (RR 2.4 [95% CI 1.9-3.2]). It was greatly elevated for fatal poisoning from a variety of agents, including psychotropic drugs and "other and unspecified medication," as well as narcotics, alcohol, and carbon monoxide. Almost 9% of all fatal poisoning cases in the diabetes cohort were identified as overdoses of insulin or oral hypoglycemic drugs. CONCLUSIONS: Various causes of unnatural death, in particular deliberate and accidental poisonings, occur more frequently among diabetic patients. Before preventive strategies can be implemented, a deeper understanding of the risk factors and causal mechanisms explaining the marked elevations in risk is needed. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/24848285/Unnatural_deaths_in_a_national_cohort_of_people_diagnosed_with_diabetes_ DB - PRIME DP - Unbound Medicine ER -